Effect of Surgical Therapy on RANKL/OPG (Osteoprotegerin) System
Effect of Surgical Periodontal Therapy on the RANKL/OPG System : Do we Need Osteo-immune Modulation Targeting RANKL?
1 other identifier
observational
65
1 country
1
Brief Summary
In the present clinical study including chronic, aggressive periodontitis and healthy individuals, the investigators aimed to determine the RANKL, osteoprotegrin (OPG), Interleukin-1 (IL-1β), IL-10, IL-1β levels in gingival crevicular fluid(GCF) before and after surgical periodontal treatment and search out the relationship of clinical parameters with these cytokine levels.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for all trials
Started Jan 2010
Typical duration for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
January 1, 2010
CompletedPrimary Completion
Last participant's last visit for primary outcome
April 1, 2013
CompletedStudy Completion
Last participant's last visit for all outcomes
April 1, 2013
CompletedFirst Submitted
Initial submission to the registry
July 8, 2014
CompletedFirst Posted
Study publicly available on registry
July 15, 2014
CompletedJuly 15, 2014
July 1, 2014
3.2 years
July 8, 2014
July 13, 2014
Conditions
Keywords
Outcome Measures
Primary Outcomes (3)
RANKL (pmol) level in GCF
Changes in RANKL levels 3 months after surgical periodontal treatment in Chronic and Aggressive periodontitis determined by ELISA
Baseline-3 months
OPG level (pg) in GCF
Changes in OPG levels 3 months after surgical periodontal treatment in Chronic and Aggressive periodontitis determined by ELISA
Baseline-3 months
RANKL/OPG ratio
RANKL/OPG ratio changes 3 months after surgical periodontal treatment in Chronic and Aggressive periodontitis
Baseline - 3months
Secondary Outcomes (2)
IL-1β (pg) levels in GCF
Baseline, 3 months after treatment
Il-10 (pg) levels in GCF
Baseline-3 months
Study Arms (3)
Chronic periodontitis
Surgical periodontal treatment and GCF collection 3 months after treatment
Agressive periodontitis
Surgical periodontal treatment and GCF collection 3 months after treatment.
Control group
Periodontally healthy individuals
Eligibility Criteria
Individulas that applied to periodontology clinic in faculty of dentistry, Hacettepe University.
You may qualify if:
- Chronic periodontitis having at least 5mm or more probing depth and aggressive periodontitis patients.
You may not qualify if:
- Any known systemic disorder, used antibiotics and/or anti-inflammatory medications, had periodontal treatment in the last 3 months and all of them were non smokers. Subjects who were lactating and pregnant were also excluded.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Hacettepe University
Ankara, 06100, Turkey (Türkiye)
Biospecimen
Gingival Crevicular fluid (GCF) is collected at baseline and 3 months after the surgical treatment.
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Design
- Study Type
- observational
- Observational Model
- CASE CONTROL
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Ezel Berker
Study Record Dates
First Submitted
July 8, 2014
First Posted
July 15, 2014
Study Start
January 1, 2010
Primary Completion
April 1, 2013
Study Completion
April 1, 2013
Last Updated
July 15, 2014
Record last verified: 2014-07