A Study of Oral Vismodegib for the Treatment of Idiopathic Pulmonary Fibrosis (IPF)

NCT02168530 | Withdrawn Phase 2

• 2 other identifiers: GB292982014-000963-42
• Study Type: interventional
• Target: N/A
• Locations: 0 countries
• Sites: N/A

Brief Summary

This is a randomized, multicenter, double-blind, placebo-controlled, parallel-group study of vismodegib in patients with IPF. Eligible patients will be randomized in a 2:1 ratio to one of two treatment arms: vismodegib or placebo. The duration of treatment will be 52 weeks. Study drug will be administered daily by the oral route. An 8-week safety follow-up period is included for all patients who receive at least one dose of study drug.

Conditions

Idiopathic Pulmonary Fibrosis

Outcome Measures

Primary Outcomes (1)

• Change in forced vital capacity (FVC) percent predicted

  From baseline to Week 52

Secondary Outcomes (6)

• Change in diffusion capacity of the lung for carbon dioxide (DLCO)

  From baseline to Week 52

• Annualized rate of change in FVC

  Week 52

• Progression-free survival

  Week 52

• Time from randomization to first event of acute IPF exacerbation

  Up to 52 weeks

• Change in Quality of Life measurements

  From baseline to Week 52

Study Arms (2)

Placebo

PLACEBO COMPARATOR

Drug: placebo

Vismodegib

EXPERIMENTAL

Drug: vismodegib

Interventions

placebo DRUG

matching placebo administered daily orally

Placebo

vismodegib DRUG

vismodegib 150 mg administered daily orally

Vismodegib

Eligibility Criteria

• Age: 40 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Adult patients aged \>/=40 years at Visit 1
• Diagnosis of IPF within the previous 5 years from time of screening and confirmed at baseline
• Patients from countries where a treatment is licensed/approved for IPF must additionally meet at least one of the following criteria to be eligible: (1) be unable to access a licensed therapy for IPF; (2) treatment with a licensed therapy/therapies has been stopped for lack of efficacy or because of safety/tolerability reasons (a washout period will be required); (3) be unwilling to be treated with a licensed therapy and study enrollment considered appropriate.
• Forced vital capacity (FVC) \>/=40% and \</=90% of predicted at screening
• Stable baseline lung function as evidenced by a difference of \<10% in absolute FVC measurements (in liters) between screening and Day 1/Visit 2 prior to randomization
• Diffusion capacity of the lung for carbon dioxide (DLCO) \>/=25% of predicted at screening
• Adequate hematopoietic capacity, liver and renal function
• Female patients of childbearing potential must use two methods of acceptable contraception, including one highly effective method and a barrier method, during treatment and for 7 months after completion of study treatment (or as per local requirement)
• Male patients must agree to remain abstinent or use a condom, even after a vasectomy, during sexual intercourse with female partners while being treated with vismodegib/placebo, and for 2 months after completion of study treatment
• Agreement not to donate blood or blood products during the study and for at least 7 months (or as per local requirements) after the last dose of study treatment

You may not qualify if:

• Pregnant or lactating
• Known hypersensitivity to any of the study drug excipients or the drug itself
• Prior treatment with vismodegib or any Hh-pathway inhibitor
• Evidence of other known causes of interstitial lung disease
• Hospitalization due to an exacerbation of IPF within 4 weeks prior to, or during, screening
• Lung transplant expected within 12 months of screening
• Evidence of clinically significant lung disease other than IPF
• Substantial emphysema on high resolution computed tomography (HRCT) with degree of emphysema greater than fibrosis
• Post bronchodilator forced expiratory volume in 1 second/FVC ratio \<0.7 at screening
• Class IV New York Heart Association chronic heart failure or historical evidence of left ventricular ejection fraction \<35%
• Known current malignancy or current evaluation for a potential malignancy
• Known immunodeficiency, including but not limited to HIV infection
• Any clinically significant medical disease (other than IPF) that is associated with an expected survival of \<12 months, likely to require a change in therapy during the study, or likely to impact the ability of the patient to participate in the study in the opinion of the investigator, or impact the study efficacy or safety assessments

Sponsors & Collaborators

• Hoffmann-La Roche: lead

MeSH Terms

Conditions

Idiopathic Pulmonary Fibrosis

Interventions

HhAntag691

Condition Hierarchy (Ancestors)

Pulmonary Fibrosis; Lung Diseases, Interstitial; Lung Diseases; Respiratory Tract Diseases

Study Officials

• Clinical Trials

  Hoffmann-La Roche

  STUDY DIRECTOR

Study Design

• Study Type: interventional
• Phase: phase 2
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, INVESTIGATOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: INDUSTRY
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: June 18, 2014
• First Posted: June 20, 2014
• Study Start: October 1, 2014
• Primary Completion: January 1, 2017
• Study Completion: January 1, 2017
• Last Updated: November 2, 2016

Record last verified: 2016-11