Success Metrics

Clinical Success Rate
77.1%

Based on 37 completed trials

Completion Rate
77%(37/48)
Active Trials
15(22%)
Results Posted
89%(33 trials)
Terminated
11(16%)

Phase Distribution

Ph phase_2
41
60%
Ph phase_4
1
1%
Ph phase_1
19
28%
Ph early_phase_1
4
6%

Phase Distribution

23

Early Stage

41

Mid Stage

1

Late Stage

Phase Distribution65 total trials
Early Phase 1First-in-human
4(6.2%)
Phase 1Safety & dosage
19(29.2%)
Phase 2Efficacy & side effects
41(63.1%)
Phase 4Post-market surveillance
1(1.5%)

Highest Phase Reached

Phase 4

Trial Status & Enrollment

Completion Rate

72.5%

37 of 51 finished

Non-Completion Rate

27.5%

14 ended early

Currently Active

15

trials recruiting

Total Trials

68

all time

Status Distribution
Active(15)
Completed(37)
Terminated(14)
Other(2)

Detailed Status

Completed37
Terminated11
Recruiting10
Active, not recruiting5
Withdrawn3
unknown2

Development Timeline

Analytics

Development Status

Total Trials
68
Active
15
Success Rate
77.1%
Most Advanced
Phase 4

Trials by Phase

Early Phase 14 (6.2%)
Phase 119 (29.2%)
Phase 241 (63.1%)
Phase 41 (1.5%)

Trials by Status

withdrawn34%
unknown23%
active_not_recruiting57%
recruiting1015%
terminated1116%
completed3754%

Recent Activity

Clinical Trials (68)

Showing 20 of 68 trialsScroll for more
NCT06357988Phase 2

Testing GDC-0449 (Vismodegib) as Potentially Targeted Treatment in Cancers With Smoothened or Patched 1 Mutant Tumors (MATCH - Subprotocol T)

Active Not Recruiting
NCT02465060Phase 2

Targeted Therapy Directed by Genetic Testing in Treating Patients With Advanced Refractory Solid Tumors, Lymphomas, or Multiple Myeloma (The MATCH Screening Trial)

Active Not Recruiting
NCT00878163Phase 1

GDC-0449 and Erlotinib Hydrochloride With or Without Gemcitabine Hydrochloride in Treating Patients With Metastatic Pancreatic Cancer or Solid Tumors That Cannot Be Removed by Surgery

Active Not Recruiting
NCT01267955Phase 2

Vismodegib in Treating Patients With Advanced Chondrosarcomas

Active Not Recruiting
NCT03297606Phase 2

Canadian Profiling and Targeted Agent Utilization Trial (CAPTUR)

Recruiting
NCT02523014Phase 2

Vismodegib, FAK Inhibitor GSK2256098, Capivasertib, and Abemaciclib in Treating Patients With Progressive Meningiomas

Recruiting
NCT06616623Phase 1

Vismodegib and Atezolizumab for the Treatment of Recurrent or Metastatic Non-Small Cell Lung Cancer

Recruiting
NCT05538091Phase 2

Vismodegib Combined With Atezolizumab in Platinum Resistant Ovarian, Fallopian Tube, and Primary Peritoneal Cancer

Recruiting
NCT03498521Phase 2

A Phase II Randomized Study Comparing the Efficacy and Safety of Targeted Therapy or Cancer Immunotherapy Versus Platinum-Based Chemotherapy in Patients With Cancer of Unknown Primary Site

Completed
NCT01878617Phase 2

A Clinical and Molecular Risk-Directed Therapy for Newly Diagnosed Medulloblastoma

Active Not Recruiting
NCT05561634Phase 2

Radiotherapy by Sonic Hedgehog Pathway Inhibitors in Basal Cell Carcinoma

Recruiting
NCT04341181Phase 2

ProTarget - A Danish Nationwide Clinical Trial on Targeted Cancer Treatment Based on Genomic Profiling

Recruiting
NCT05463757

Oral Hedgehog Inhibitors in the Treatment of Basal Cell Carcinoma in the Netherlands: a Prospective Registration Study

Recruiting
NCT01064622Phase 2

Gemcitabine Hydrochloride With or Without Vismodegib in Treating Patients With Recurrent or Metastatic Pancreatic Cancer

Completed
NCT06344052Phase 2

To Assess the Safety and Efficacy of SP-002 with Vismodegib for the Treatment of Locally Advanced Basal Cell Carcinoma

Recruiting
NCT01774253Phase 2

Erivedge (Vismodegib) in the Treatment of Pediatric Patients With Refractory Pontine Glioma

Terminated
NCT02091141Phase 2

My Pathway: A Study Evaluating Herceptin/Perjeta, Tarceva, Zelboraf/Cotellic, Erivedge, Alecensa, and Tecentriq Treatment Targeted Against Certain Molecular Alterations in Participants With Advanced Solid Tumors

Completed
NCT05159245Phase 2

The Finnish National Study to Facilitate Patient Access to Targeted Anti-cancer Drugs

Recruiting
NCT03878524Phase 1

Serial Measurements of Molecular and Architectural Responses to Therapy (SMMART) PRIME Trial

Terminated
NCT02925234Phase 2

The Drug Rediscovery Protocol (DRUP Trial)

Recruiting

Drug Details

Intervention Type
DRUG
Total Trials
68