NCT02163668

Brief Summary

This study examined the effects of 8 months of Yoga training on bone density and bone turnover markers in premenopausal women, ages 35-50 years. The style of Yoga used was power Yoga that involved postures with a jumping component. The investigators hypothesized that the Yoga intervention would result in beneficial improvements in bone turnover markers, by increasing the bone formation marker and decreasing the bone resorption marker.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
47

participants targeted

Target at P25-P50 for not_applicable

Timeline
Completed

Started Sep 2009

Typical duration for not_applicable

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

September 1, 2009

Completed
9 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

June 1, 2010

Completed
1.8 years until next milestone

Study Completion

Last participant's last visit for all outcomes

April 1, 2012

Completed
2.2 years until next milestone

First Submitted

Initial submission to the registry

June 9, 2014

Completed
7 days until next milestone

First Posted

Study publicly available on registry

June 16, 2014

Completed
Last Updated

June 16, 2014

Status Verified

June 1, 2014

Enrollment Period

9 months

First QC Date

June 9, 2014

Last Update Submit

June 13, 2014

Conditions

Bone HealthOsteoporosis

Keywords

YogaBone turnover markersBone strengthBone mineral density

Outcome Measures

Primary Outcomes (6)

  • Change in bone mineral density from baseline to 8 months

    pre and post 8 months training

  • change in bone turnover markers

    pre and post 8 month intervention

  • change in tibia bone characteristics

    changes in volumetric bone mineral density and bone strength of the non-dominant tibia assessed by peripheral Quantitative Computed Tomography (pQCT)

    pre and post 8 month intervention

  • Changes in muscular strength

    Isotonic 1 repetition maximum (1RM) for 4 lower body and 2 upper body resistance exercises

    pre and post 9 month intervention

  • Change in arterial compliance

    Arterial compliance of the large and small arteries was assessed using Pulse Contour analysis.

    pre and post 8 month interventon

  • Change in Insulin-like Growth Factor-1 (IGF-I) and Insulin-like Growth Factor BP3 (IGFBP3)

    pre and post 8 month intervention

Secondary Outcomes (5)

  • Daily Calcium intake

    pre and post 8 month intervention

  • Menstrual History

    pre and post 8 month intervention

  • Dietary intake

    At baseline at the same time as other outcomes, about 2 weeks before the beginning of the yoga training

  • Change in physical activity levels

    pre and post 8 month intervention

  • Change in body composition

    pre and post 8 month intervention

Study Arms (2)

Yoga group

EXPERIMENTAL

8 months of progressive Yoga training

Other: Yoga Group

Control group

NO INTERVENTION

No training, just pre and post testing

Interventions

Yoga GroupOTHER

8 months of Yoga training

Yoga group

Eligibility Criteria

Age35 Years - 50 Years
Sexfemale
Healthy VolunteersYes
Age GroupsAdult (18-64)

You may qualify if:

  • participants had not been engaged in resistance training or in Yoga exercise for at least 12 months prior to the study
  • did not have chronic back or joint problems or cardiovascular disease
  • not taking antihypertensive drugs or any medication that affects bone density
  • not taking hormonal contraception
  • they self-reported having regular menstrual cycles.

You may not qualify if:

  • body weight more than 300 pounds

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Department of Health and Exercise Science, University of Oklahoma

Norman, Oklahoma, 73019, United States

Location

Related Publications (2)

  • Phoosuwan M, Kritpet T, Yuktanandana P. The effects of weight bearing yoga training on the bone resorption markers of the postmenopausal women. J Med Assoc Thai. 2009 Sep;92 Suppl5:S102-8.

    PMID: 19891384BACKGROUND

  • Chan K, Qin L, Lau M, Woo J, Au S, Choy W, Lee K, Lee S. A randomized, prospective study of the effects of Tai Chi Chun exercise on bone mineral density in postmenopausal women. Arch Phys Med Rehabil. 2004 May;85(5):717-22. doi: 10.1016/j.apmr.2003.08.091.

    PMID: 15129394BACKGROUND

MeSH Terms

Conditions

Osteoporosis

Condition Hierarchy (Ancestors)

Bone Diseases, MetabolicBone DiseasesMusculoskeletal DiseasesMetabolic DiseasesNutritional and Metabolic Diseases

Study Officials

  • Debra A Bemben, PhD

    Department of Health and Exercise Science, University of Oklahoma

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
NONE
Purpose
PREVENTION
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Professor

Study Record Dates

First Submitted

June 9, 2014

First Posted

June 16, 2014

Study Start

September 1, 2009

Primary Completion

June 1, 2010

Study Completion

April 1, 2012

Last Updated

June 16, 2014

Record last verified: 2014-06

Locations

US(1)