The Effect of Blood Transfusion on Endothelial Function

NCT02161042 | Completed

• 1 other identifier: 100344
• Study Type: observational
• Target: 40
• Locations: 1 country
• Sites: 1

Brief Summary

Blood transfusion is often used to treat patients with Anemia. The period of storage of blood products prior to use for transfusion may vary. Prolonged storage of blood products may result in changing their biochemistry. This study aims to look into whether the transfusion of "old" blood, which is stored for more than 7 days, as compared to the transfusion of "Fresh" blood, which is stored for less than 7 days, will affect endothelial function.

Conditions

MDS; Anemia

Keywords

Blood transfusion; Storage Lesion; Endothelial dysfunction; Nitric Oxide

Outcome Measures

Primary Outcomes (1)

• Endothelial function

  The function of the blood vessels will be assessed with the EndoPAT device. This test is done 15 minutes prior to the transfusion and again 30 minutes post the transfusion. Patients that will receive both fresh and old blood will be included.

  Change in endothelial function compared to baseline. Test is done 15 minutes prior to transfusion and 30 minutes post blood transfusion. The test is repeated when patient received another blood transfusion. The results of the change are compared.

Study Arms (2)

fresh blood Transfusion

Old blood transfusion

Eligibility Criteria

• Age: 18 Years - 95 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients who come to IV therapy or Oncology day Unit requiring a blood transfusion

You may qualify if:

• Age is \> 18 years
• Need recurrent blood transfusion

You may not qualify if:

• Latex Allergy
• Life expectancy is less than 6 months
• History or evidence of drug or alcohol abuse in the last 12 months
• Any medical condition that will place the participant at a higher risk if they participate in the study

Sponsors & Collaborators

• London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's: lead

Study Sites (1)

London Health Sciences Centre

London, Ontario, N6A5A5, Canada

Location

Related Publications (3)

• Donadee C, Raat NJ, Kanias T, Tejero J, Lee JS, Kelley EE, Zhao X, Liu C, Reynolds H, Azarov I, Frizzell S, Meyer EM, Donnenberg AD, Qu L, Triulzi D, Kim-Shapiro DB, Gladwin MT. Nitric oxide scavenging by red blood cell microparticles and cell-free hemoglobin as a mechanism for the red cell storage lesion. Circulation. 2011 Jul 26;124(4):465-76. doi: 10.1161/CIRCULATIONAHA.110.008698. Epub 2011 Jul 11.

  PMID: 21747051 BACKGROUND

• Kim-Shapiro DB, Lee J, Gladwin MT. Storage lesion: role of red blood cell breakdown. Transfusion. 2011 Apr;51(4):844-51. doi: 10.1111/j.1537-2995.2011.03100.x.

  PMID: 21496045 BACKGROUND

• Chin-Yee I, Arya N, d'Almeida MS. The red cell storage lesion and its implication for transfusion. Transfus Sci. 1997 Sep;18(3):447-58. doi: 10.1016/S0955-3886(97)00043-X.

  PMID: 10175158 BACKGROUND

MeSH Terms

Conditions

Anemia

Condition Hierarchy (Ancestors)

Hematologic Diseases; Hemic and Lymphatic Diseases

Study Design

• Study Type: observational
• Observational Model: CASE CROSSOVER
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Interventional Cardiologist

Study Record Dates

• First Submitted: June 6, 2014
• First Posted: June 11, 2014
• Study Start: August 1, 2011
• Primary Completion: January 1, 2016
• Study Completion: June 1, 2016
• Last Updated: October 5, 2016

Record last verified: 2016-10

Locations

CA (1)