Emotional and Change-related Attention in Autism

NCT02160119 | Completed

• 2 other identifiers: C13-262013-A01315-40
• Study Type: observational
• Target: 120
• Locations: 1 country
• Sites: 1

Brief Summary

Several studies seem to indicate that emotional attention and change-related attention are impaired in ASD. The goal of this study is to identify the relationships between those two types of automatic attention in visual and auditory modalities in subjects with ASD compared to healthy controls and also, over the course of development (children, adults). In order to achieve this goal, the investigators will use complementary techniques (EEG and MRI-based techniques (fMRI, DTI)).

Conditions

Autism Spectrum Disorders

Keywords

Autism Spectrum Disorders; Emotion; Attention; Event-related potential; Functional neuroimaging; Diffusion Tensor Imaging; Development

Outcome Measures

Primary Outcomes (1)

• Neural responses to neutral and emotional stimuli

  ERP (Event-related potential), fMRI and DTI

  1 day

Study Arms (2)

Healthy Controls

Other: MRI-based techniques; Other: EEG

Autism Spectrum Disorders

Other: MRI-based techniques; Other: EEG

Interventions

MRI-based techniques OTHER

fMRI, DTI

Also known as: Functional magnetic resonance imaging, Diffusion Tensor Imaging

Autism Spectrum Disorders; Healthy Controls

EEG OTHER

ERP

Also known as: Electroencephaolgraphy, Event-related potential (ERP)

Autism Spectrum Disorders; Healthy Controls

Eligibility Criteria

• Age: 5 Years - 45 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

Children/ adults with ASD and healthy children/ adults

You may qualify if:

• No past history of central nervous system disorders
• Written consent
• Affiliated to the National Health Insurance
• Do not participate to another biomedical research
• For ASD group: Children with autism spectrum disorder (DSM-V criteria) and adults with high-functioning autism
• For healthy subjects: No past history of difficulties in early childhood for acquisition of walk, language or reading and no psychiatric disorders

You may not qualify if:

• Abnormal corrected vision
• Abnormal audition
• Not stabilized psychoactive treatment or treatment that can modify electrogenesis
• Infectious or metabolic diseases
• Epilepsies
• Impossibility to participate to the whole study
• For subjects participating to the MRI recordings: MRI counter-indications (pace-makers ...), claustrophobia or a positive pregnancy test

Sponsors & Collaborators

• Institut National de la Santé Et de la Recherche Médicale, France: lead

Study Sites (1)

University Hospital

Tours, 37044, France

Location

Related Publications (5)

• Charpentier J, Kovarski K, Roux S, Houy-Durand E, Saby A, Bonnet-Brilhault F, Latinus M, Gomot M. Brain mechanisms involved in angry prosody change detection in school-age children and adults, revealed by electrophysiology. Cogn Affect Behav Neurosci. 2018 Aug;18(4):748-763. doi: 10.3758/s13415-018-0602-8.

  PMID: 29736682 RESULT

• Kovarski K, Latinus M, Charpentier J, Clery H, Roux S, Houy-Durand E, Saby A, Bonnet-Brilhault F, Batty M, Gomot M. Facial Expression Related vMMN: Disentangling Emotional from Neutral Change Detection. Front Hum Neurosci. 2017 Jan 30;11:18. doi: 10.3389/fnhum.2017.00018. eCollection 2017.

  PMID: 28194102 RESULT

• Charpentier J, Latinus M, Andersson F, Saby A, Cottier JP, Bonnet-Brilhault F, Houy-Durand E, Gomot M. Brain correlates of emotional prosodic change detection in autism spectrum disorder. Neuroimage Clin. 2020;28:102512. doi: 10.1016/j.nicl.2020.102512. Epub 2020 Nov 27.

  PMID: 33395999 RESULT

• Kovarski K, Charpentier J, Roux S, Batty M, Houy-Durand E, Gomot M. Emotional visual mismatch negativity: a joint investigation of social and non-social dimensions in adults with autism. Transl Psychiatry. 2021 Jan 5;11(1):10. doi: 10.1038/s41398-020-01133-5.

  PMID: 33414385 RESULT

• Charpentier J, Kovarski K, Houy-Durand E, Malvy J, Saby A, Bonnet-Brilhault F, Latinus M, Gomot M. Emotional prosodic change detection in autism Spectrum disorder: an electrophysiological investigation in children and adults. J Neurodev Disord. 2018 Sep 18;10(1):28. doi: 10.1186/s11689-018-9246-9.

  PMID: 30227832 RESULT

MeSH Terms

Conditions

Autism Spectrum Disorder

Interventions

Diffusion Tensor Imaging; Evoked Potentials

Condition Hierarchy (Ancestors)

Child Development Disorders, Pervasive; Neurodevelopmental Disorders; Mental Disorders

Intervention Hierarchy (Ancestors)

Neuroimaging; Diagnostic Imaging; Diagnostic Techniques and Procedures; Diagnosis; Diffusion Magnetic Resonance Imaging; Magnetic Resonance Imaging; Tomography; Diagnostic Techniques, Neurological; Investigative Techniques; Cortical Excitability; Electrophysiological Phenomena; Physiological Phenomena; Nervous System Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Officials

• Frédérique BONNET-BRILHAULT, MD,PhD

  Institut National de la Santé Et de la Recherche Médicale, France

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER GOV
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: June 3, 2014
• First Posted: June 10, 2014
• Study Start: May 27, 2014
• Primary Completion: May 1, 2018
• Study Completion: May 27, 2018
• Last Updated: November 18, 2025

Record last verified: 2021-08

Locations

FR (1)