Social Interactions: Ocular Explorations and Pupillometry in Autism

NCT01647295 | Completed

• 2 other identifiers: C11-602012-A00520-43
• Study Type: observational
• Target: 150
• Locations: 1 country
• Sites: 1

Brief Summary

The primary objective of this work will first to characterize in typical childhood, visual exploratory behavior and pupillary response associated with salience of human social stimuli (faces and body movements), and then to evaluate these markers in children with autism. The second objective of this work will be to achieve in a population of children with autism a longitudinal evaluation of these markers during development and therapeutics.

Conditions

Autism Spectrum Disorders

Keywords

visual exploration; pupil size; social interactions; faces; human motion

Outcome Measures

Primary Outcomes (1)

• Total time spent on pictures

  Total time tracked during exploration of faces and human motion, compared to objects

  two years

Secondary Outcomes (1)

• Interest zones

  two years

Eligibility Criteria

• Age: 3 Years - 12 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17)
• Sampling Method: Non-Probability Sample

Study Population

Autistic children from the University Hospital of Tours Healthy children from the normal population

You may qualify if:

• For autistic children, diagnosis of autism spectrum disorders according to DSM IV-TR and ADI / ADOS criteria ; normal or corrected vision; no nervous system disease
• For healthy children, normal schooling and normal or corrected vision
• For all, parental consents

You may not qualify if:

• psychotropic treatment

Sponsors & Collaborators

• Institut National de la Santé Et de la Recherche Médicale, France: lead

Study Sites (1)

CHRU Bretonneau

Tours, 37044, France

Location

Related Publications (1)

• Aguillon-Hernandez N, Mofid Y, Latinus M, Roche L, Bufo MR, Lemaire M, Malvy J, Martineau J, Wardak C, Bonnet-Brilhault F. The pupil: a window on social automatic processing in autism spectrum disorder children. J Child Psychol Psychiatry. 2020 Jul;61(7):768-778. doi: 10.1111/jcpp.13170. Epub 2019 Dec 11.

  PMID: 31823380 RESULT

MeSH Terms

Conditions

Autism Spectrum Disorder; DiGeorge Syndrome

Condition Hierarchy (Ancestors)

Child Development Disorders, Pervasive; Neurodevelopmental Disorders; Mental Disorders; 22q11 Deletion Syndrome; Craniofacial Abnormalities; Musculoskeletal Abnormalities; Musculoskeletal Diseases; Heart Defects, Congenital; Cardiovascular Abnormalities; Cardiovascular Diseases; Heart Diseases; Lymphatic Abnormalities; Lymphatic Diseases; Hemic and Lymphatic Diseases; Abnormalities, Multiple; Congenital Abnormalities; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Chromosome Disorders; Genetic Diseases, Inborn; Hypoparathyroidism; Parathyroid Diseases; Endocrine System Diseases

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER GOV
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: July 19, 2012
• First Posted: July 23, 2012
• Study Start: February 25, 2013
• Primary Completion: June 1, 2019
• Study Completion: June 18, 2019
• Last Updated: December 4, 2025

Record last verified: 2021-08

Locations

FR (1)