Disease Progression and Treatment-induced Alterations in Glioblastoma

NCT02152748 | Unknown DMC

• 1 other identifier: KLI 394
• Study Type: observational
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

Summary of scientific evidence and rationale of this project: Integrative molecular-genetic approaches have provided important insights in the biology of glioblastoma. It has meanwhile become clear, that glioblastoma is not a single tumor entity but comprises different molecular subtypes, which are associated with a distinct genetic/epigenetic signature and prognosis. Multimodal treatment approaches combining radio- and chemotherapy as well as the recent introduction of novel antiangiogenic agents have resulted in increasing survival times and improved quality-of-life of glioblastoma patients. Yet, despite these intense treatment efforts the therapeutic efficacy in glioblastoma patients is limited, leading in virtually all cases to tumor recurrence and death of the patients. As only a limited fraction of glioblastoma patients undergo second neurosurgery at tumor recurrence (\< 10%), post-therapeutic samples are rare and no systematic, large-scale studies exist, which address post-therapeutic morphological and molecular alterations in glioblastoma tumor tissue. Yet, these data would help to improve the understanding of mechanisms involved in therapy-resistance and tumor progression, to develop new therapeutic approaches and could pave the way for personalized treatment strategies.

Conditions

Brain Tumor

Keywords

glioblastoma; morphological and molecular changes; progression; therapy-resistance

Outcome Measures

Primary Outcomes (2)

• Morphology- based analysis

  Histopathological workup and evaluation

  24 months

• Molecular analysis

  Assessment of genomic alterations at DNA-, RNA- and methylation level

  24 months

Study Arms (1)

Glioblastoma

The aim of this study is to analyze systematically morphological and molecular changes associated with glioblastoma progression and therapy-resistance in matched pre- and post-therapeutic glioblastoma samples.

Genetic: analyze systematically morphological and molecular changes associated with glioblastoma progression and therapy-resistance

Interventions

analyze systematically morphological and molecular changes associated with glioblastoma progression and therapy-resistance GENETIC

Glioblastoma

Sponsors & Collaborators

• Medical University of Vienna: lead

Study Sites (1)

Medical University of Vienna, Institute of Neurology

Vienna, Vienna, 1090, Austria

Location

Biospecimen

Retention: SAMPLES WITH DNA

Tissue

MeSH Terms

Conditions

Brain Neoplasms; Glioblastoma; Disease Progression

Condition Hierarchy (Ancestors)

Central Nervous System Neoplasms; Nervous System Neoplasms; Neoplasms by Site; Neoplasms; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Astrocytoma; Glioma; Neoplasms, Neuroepithelial; Neuroectodermal Tumors; Neoplasms, Germ Cell and Embryonal; Neoplasms by Histologic Type; Neoplasms, Glandular and Epithelial; Neoplasms, Nerve Tissue; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Adelheid Wöhrer, MD PhD

  Medical University Vienna

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Dr.med.univ et scient.med.

Study Record Dates

• First Submitted: May 22, 2014
• First Posted: June 2, 2014
• Study Start: April 1, 2014
• Primary Completion: December 1, 2017
• Study Completion: December 1, 2017
• Last Updated: March 22, 2017

Record last verified: 2017-03

Locations

AU (1)