Magnesium and Metabolic Syndrome: A Dose-response Meta-analysis

NCT02151227 | Completed

• 1 other identifier: SC14EISI0086
• Study Type: observational
• Target: 12
• Locations: 1 country
• Sites: 1

Brief Summary

Magnesium is an essential mineral found in many foods; rich sources include whole grains, green leafy vegetables, coffee, and legumes. Magnesium is a critical cofactor in \>300 enzymatic reactions, including those related to energy metabolism. Reduced magnesium intake and serum concentrations have been detected, both cross-sectionally and prospectively,in type 2 diabetes and insulin resistance, hypertension, dyslipidemia, and cardiovascular diseases. Different studies have reported inadequate magnesium intake and low serum magnesium concentrations may correlated also with metabolic syndrome, defined as a cluster of metabolic disorders including obesity, hypertension, dyslipidemia and impaired glucose tolerance or diabetes mellitus. Previous studies on this subject, however, reported contradicting results. Some investigations reported inadequate magnesium intake and low serum magnesium concentrations while others did not. To our knowledge, the epidemiological evidence on the relation between dietary magnesium intake and risk of metabolic syndrome has not yet been summarized.Therefore, the investigators will perform a systematic review and dose-response meta-analysis to assess the association between dietary and circulating magnesium level and risk of metabolic syndrome.

Conditions

Metabolic Syndrome X; Insulin Resistance Syndrome X; Metabolic Cardiovascular Syndrome; Dysmetabolic Syndrome X

Keywords

Meta-Analysis; Metabolic Syndrome; Magnesium; Dose Response Effect; Systematic Review

Outcome Measures

Primary Outcomes (1)

• Metabolic syndrome risk ratios (Odds ratio, Relative risk, Hazard ratio)

  Baseline

Secondary Outcomes (1)

• Serum magnesium concentration (mg/dL, mmol/L)

  Baseline

Study Arms (1)

magnesium intake categories

comparators: categories of magnesium intake except lowest category of magnesium intake , controls: lowest category of magnesium intake

Eligibility Criteria

• Age: 18 Years - 90 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Adult population: 18 years old and older

You may qualify if:

• Dietary studies in humans 18 years old and older
• Randomized controlled study, Cohort study, Nested case-control study, Case-control study, Cross-sectional study
• The exposure of interest is magnesium intake (mg/day) or serum magnesium concentration(mmol/L, mg/dL)

You may not qualify if:

• Non-human studies
• Authors did not make serum magnesium concentration measurement;
• The outcome values can not be used for meta-analysis
• Duplicated articles.
• Studies are not published as full reports, such as conference abstracts and letters to editors

Sponsors & Collaborators

• The Catholic University of Korea: lead

Study Sites (1)

Sang-Yhun Ju

Seoul, 150-713, South Korea

Location

Related Publications (2)

• Ju SY, Choi WS, Ock SM, Kim CM, Kim DH. Dietary magnesium intake and metabolic syndrome in the adult population: dose-response meta-analysis and meta-regression. Nutrients. 2014 Dec 22;6(12):6005-19. doi: 10.3390/nu6126005.

  PMID: 25533010 RESULT

• La SA, Lee JY, Kim DH, Song EL, Park JH, Ju SY. Low Magnesium Levels in Adults with Metabolic Syndrome: a Meta-Analysis. Biol Trace Elem Res. 2016 Mar;170(1):33-42. doi: 10.1007/s12011-015-0446-9. Epub 2015 Jul 26.

  PMID: 26208810 DERIVED

Related Links

• pubmed

MeSH Terms

Conditions

Metabolic Syndrome

Condition Hierarchy (Ancestors)

Insulin Resistance; Hyperinsulinism; Glucose Metabolism Disorders; Metabolic Diseases; Nutritional and Metabolic Diseases

Study Officials

• Sang-yhun Ju, Ph.D.

  Department of Family Medicine, Yeouido St. Mary's Hospital, College of Medicine, The Catholic University of Korea

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: M.D., Ph.D., Clinical Associate Professor

Study Record Dates

• First Submitted: May 28, 2014
• First Posted: May 30, 2014
• Study Start: June 1, 2014
• Primary Completion: September 1, 2014
• Study Completion: December 1, 2014
• Last Updated: December 30, 2014

Record last verified: 2014-12

Locations

KR (1)