Epidemiology of Sudden Cardiac Arrest in Sub-Saharan Africa: Rationale and Design

NCT02142270 | Unknown

• 1 other identifier: PASCAR
• Study Type: observational
• Target: 250,000
• Locations: 1 country
• Sites: 1

Brief Summary

Background The burden of sudden cardiac death (SCD) in Africa is unknown. Our aim is to assess the epidemiology of SCD in Africa. Methods The sub-Saharan Africa SCD study is a prospective, multicenter, community-based registry monitoring all cases of cardiac arrest occurring in victims \> 15 years old. Investigators will use the definition of established SCD if an unexpected death without obvious extracardiac cause, occurred with a rapid witnessed collapse, or if unwitnessed, occurred within 1 hour after the onset of symptoms; probable SCD if an unexpected death without obvious extracardiac cause occurred within the previous 24 hours. After approval from institutional boards, Investigators will record demographic, clinical, electrocardiographic and biological variables of SCD victims (including survivors of cardiac arrest) in several sub-Saharan African cities. All deaths occurring in residents of districts of interest will be checked for past medical history, circumstances of death, and autopsy report (if possible). Investigators will also analyze the employment of resuscitation attempts during the timeframe of sudden cardiac arrest (SCA) in various patient populations throughout countries. Conclusion This study will provide comprehensive, contemporary data on the epidemiology of SCD in sub-Saharan Africa and will help in the development of strategies to prevent and manage cardiac arrest in this region of the world.

Conditions

Cardiovascular Diseases

Outcome Measures

Primary Outcomes (1)

• Sudden Cardiac Death

  3 years

Study Arms (2)

Victims of cardiac arrest, either SCD or aborted SCA

Premature death

All residents of districts of interest will be surveyed during 3 years. premature deaths occurring in residents of districts of interest will be checked for past medical history, circumstances of death, and autopsy report (if possible). Investigators will also analyze the employment of resuscitation attempts during the timeframe of sudden cardiac arrest (SCA) in various patient populations throughout African countries. The arm group of the study is every resident of the district of interest

Eligibility Criteria

• Age: 15 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

All residents of districts of interest will be surveyed during 3 years. premature deaths occurring in residents of districts of interest will be checked for past medical history, circumstances of death, and autopsy report (if possible). Investigators will also analyze the employment of resuscitation attempts during the timeframe of sudden cardiac arrest (SCA) in various patient populations throughout African countries. The arm group of the study is every resident of the district of interest

You may qualify if:

• Victims of cardiac arrest, either SCD or aborted SCA

You may not qualify if:

• Age ≤ 15 years.
• Refusal of consent (by the family).

Sponsors & Collaborators

• Cameroon Resuscitation Council: lead

Study Sites (1)

Bonny

Douala, 2701, Cameroon

Location

MeSH Terms

Conditions

Cardiovascular Diseases

Central Study Contacts

Aime Bonny

CONTACT

33637975227; aimebonny@yahoo.fr

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 3 Years
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal investigator

Study Record Dates

• First Submitted: May 10, 2014
• First Posted: May 20, 2014
• Study Start: January 1, 2015
• Primary Completion: January 1, 2016
• Study Completion: January 1, 2018
• Last Updated: May 20, 2014

Record last verified: 2014-05

Locations

CA (1)