Brown Adipose Tissue Activity and Age
1 other identifier
observational
16
1 country
1
Brief Summary
In this study the investigators aim to investigate whether the sympathetic stimulation of BAT, as assessed with a 123I-metaiodobenzylguanidine single-photon emission computed tomography computed tomography scan, differs between young and elderly subjects, as an explanation for the diminished metabolic brown adipose tissue activity in the elderly. The investigators hypothesis is that sympathetic nervous system activity in the elderly is diminished as compared to their younger counterparts as an explanation for the diminished metabolic brown adipose tissue activity in the elderly.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for all trials
Started May 2013
Shorter than P25 for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
May 1, 2013
CompletedPrimary Completion
Last participant's last visit for primary outcome
March 1, 2014
CompletedStudy Completion
Last participant's last visit for all outcomes
March 1, 2014
CompletedFirst Submitted
Initial submission to the registry
March 20, 2014
CompletedFirst Posted
Study publicly available on registry
May 5, 2014
CompletedMay 5, 2014
April 1, 2014
10 months
March 20, 2014
April 30, 2014
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Difference in sympathetic stimulation to BAT between young and older individuals
Participants will be followed for a mean duration of 2 weeks (the maximal time period between the two scans) The outcome measurements will be assessed when the last subject has been scanned approximately one year after starting the trial.
Secondary Outcomes (1)
Difference in correlation between sympathetic stimulation of BAT as assessed with 123I-MIBG SPECT scans and metabolic BAT activity as assessed with 18F-Fluorodeoxyglucose(FDG)- positron emission tomography(PET)-CT scan in young and older individuals
Participants will be followed for a mean duration of 2 weeks (the maximal time period between the two scans) The outcome measurements will be assessed when the last subject has been scanned approximately one year after starting the trial.
Study Arms (2)
Young males
Healthy, Lean, Caucasian, Young males
Old males
Healthy, Lean, Caucasian, Older males
Interventions
Eligibility Criteria
Healthy Caucasian Males
You may qualify if:
- Male
- Caucasian origin
- Subjects should be able and willing to give informed consent
- years old
- BMI range of 19-27 kg/m2
You may not qualify if:
- Renal failure (creatinine\>135mmol/l)
- Daily use of prescription medication
- Prior participation in a research protocol involving radiation exposure in the last 2 years
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Academic Medical Center
Amsterdam, 1105AZ, Netherlands
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Design
- Study Type
- observational
- Observational Model
- CASE CONTROL
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- MD, PhD
Study Record Dates
First Submitted
March 20, 2014
First Posted
May 5, 2014
Study Start
May 1, 2013
Primary Completion
March 1, 2014
Study Completion
March 1, 2014
Last Updated
May 5, 2014
Record last verified: 2014-04