Obesity and Brain: Genes and Environment

NCT02025595 | Completed

• 3 other identifiers: DC2013ObesiBrain001NL 44735.029.1391613082
• Study Type: observational
• Target: 92
• Locations: 1 country
• Sites: 1

Brief Summary

The aim of this study is to investigate the effects of genetic and environmental risk factors on central nervous system (CNS) reward and satiety circuits in the etiology of obesity. The investigators will also investigate to what extent the alterations in CNS reward and satiety circuits are a cause or a consequence of the development of obesity.

Conditions

Obesity

Keywords

Brain; Genes; Environment; Etiology; Reward; Satiety Response; Central Nervous System; Magnetic Resonance Imaging; Twins, Monozygotic; Overweight; Obesity

Outcome Measures

Primary Outcomes (3)

• The difference in neuronal activity in CNS reward and satiety circuits as represented by BOLD functional magnetic resonance imaging (fMRI) signal change from baseline (%) in response to food-related stimuli within obesity discordant MZ twin pairs.

  Baseline (one measurement)

• The difference in neuronal activity in CNS reward and satiety circuits as represented by BOLD fMRI signal change from baseline (%) in response to food-related stimuli between individuals at high verses low genetic obesity risk.

  Baseline (one measurement)

• The difference in neuronal activity in CNS reward and satiety circuits as represented by BOLD fMRI signal change from baseline (%) in response to food-related stimuli between lean and obese subjects with either high or low genetic obesity risk.

  Baseline (one measurement)

Secondary Outcomes (10)

• The difference within obesity-discordant monozygotic (MZ) twin pairs regarding dietary intake

  Baseline (one measurement)

• The difference within obesity-discordant monozygotic (MZ) twin pairs regarding physical activity level

  Baseline (one measurement)

• The difference within obesity-discordant monozygotic (MZ) twin pairs regarding basal metabolic rate

  Baseline (one measurement)

• The difference within obesity-discordant monozygotic (MZ) twin pairs regarding fasting circulating biomarker levels

  Baseline (one measurement)

• The difference within obesity-discordant monozygotic (MZ) twin pairs regarding autonomic nervous system balance

  Baseline (one measurement)

Other Outcomes (4)

• The difference within obesity-discordant monozygotic (MZ) twin pairs regarding gut microbiota composition

  Baseline (one measurement)

• The difference within obesity-discordant monozygotic (MZ) twin pairs regarding epigenetic changes

  Baseline (one measurement)

• The difference between individuals at high versus those at low genetic obesity risk regarding gut microbiota composition

  Baseline (one measurement)

Study Arms (2)

Monozygotic twin pairs

15 monozygotic twin pairs discordant for obesity

Genetic predisposition for obesity

15 obese and 15 non-obese individuals with a high genotype obesity risk score and 15 obese and 15 non-obese individuals with a low genotype obesity risk score. Genotype obesity risk score will be based on genome wide association single-nucleotide polymorphisms (SNP's) associated with obesity.

Eligibility Criteria

• Age: 18 Years - 75 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Subjects will be recruited from the Netherlands Twin Registry (NTR). All subjects are voluntary participants and have received surveys on lifestyle and health every 2 years. In addition, genome wide data are available in a large number of these individuals.

You may qualify if:

• Age 18-75 years
• Male or female
• Stable bodyweight (\<5% reported weight change during previous 3 months)
• Women: regular menstruation cycle (to exclude possible menstruation cycle effects)
• Normal fasting blood glucose

You may not qualify if:

• Left handedness
• Known diabetes or abnormal fasting blood glucose
• Serious heart, pulmonary, hepatic or renal disease, malignant or hematological disease
• Metabolic disorders (uncontrolled adrenal/thyroid disease)
• Women: irregular menstruation cycle
• Neurological or psychiatric illness
• Pregnancy or breast feeding
• Alcohol abuse
• Nicotine abuse
• Claustrophobia or metal implants
• Visual disability
• Participation in another study
• Inability to understand the protocol or to give informed consent
• Current/chronic use of following medication: antihyperglycemic agents, glucocorticoids, centrally acting drugs, cytostatics, immune suppressants, potentially addictive medications.

Sponsors & Collaborators

• Amsterdam UMC, location VUmc: lead

Study Sites (1)

VU University Medical Center

Amsterdam, 1081HV, Netherlands

Location

Related Publications (2)

• Doornweerd S, De Geus EJ, Barkhof F, Van Bloemendaal L, Boomsma DI, Van Dongen J, Drent ML, Willemsen G, Veltman DJ, IJzerman RG. Brain reward responses to food stimuli among female monozygotic twins discordant for BMI. Brain Imaging Behav. 2018 Jun;12(3):718-727. doi: 10.1007/s11682-017-9711-1.

  PMID: 28597337 DERIVED

• Doornweerd S, IJzerman RG, van der Eijk L, Neter JE, van Dongen J, van der Ploeg HP, de Geus EJ. Physical activity and dietary intake in BMI discordant identical twins. Obesity (Silver Spring). 2016 Jun;24(6):1349-55. doi: 10.1002/oby.21475. Epub 2016 Apr 23.

  PMID: 27106364 DERIVED

MeSH Terms

Conditions

Obesity; Overweight

Condition Hierarchy (Ancestors)

Overnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: MD PhD FRCPE, Professor of Internal Medicine, Chair of Diabetology, Director of Diabetes Center VUmc

Study Record Dates

• First Submitted: December 13, 2013
• First Posted: January 1, 2014
• Study Start: December 1, 2013
• Primary Completion: September 1, 2016
• Study Completion: September 1, 2016
• Last Updated: May 10, 2017

Record last verified: 2017-05

Locations

NL (1)