NCT02116595

Brief Summary

Presently, the gold standard for testing diet acid intake is a urine collection done for many hours, usually 24 hours, which must be analyzed in a research lab for "net acid excretion". So, getting information about diet acid intake is difficult. Many people have suggested doing a much simpler test, which is checking the pH of the urine when you wake up. But, no one has studied if this simpler method is a valid method for estimating the 24 hour net acid excretion. Diet acid load may be important in many diseases associated with aging, such as loss of bone and muscle, and the development of kidney disease.

Trial Health

30
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Timeline
Completed

Started Jan 2015

Typical duration for not_applicable healthy

Geographic Reach
1 country

1 active site

Status
withdrawn

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

April 15, 2014

Completed
2 days until next milestone

First Posted

Study publicly available on registry

April 17, 2014

Completed
9 months until next milestone

Study Start

First participant enrolled

January 1, 2015

Completed
5 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

June 1, 2015

Completed
11 months until next milestone

Study Completion

Last participant's last visit for all outcomes

May 1, 2016

Completed
Last Updated

July 27, 2017

Status Verified

July 1, 2017

Enrollment Period

5 months

First QC Date

April 15, 2014

Last Update Submit

July 25, 2017

Conditions

Healthy

Keywords

volunteers

Outcome Measures

Primary Outcomes (2)

  • high acid diet

    correlation between first morning urine pH and 24 hour net acid excretion

    6 months

  • low acid diet

    correlation between first morning urine pH and 24 hour net acid excretion

    6 months

Study Arms (2)

feeding a high acid diet x 24 hrs

EXPERIMENTAL

2 diets, one low and one high net acid loads

Other: high or low acid diet

low acid diet

ACTIVE COMPARATOR
Other: high or low acid diet

Interventions

high or low acid dietOTHER

high or low acid diets

feeding a high acid diet x 24 hrslow acid diet

Eligibility Criteria

Age18 Years - 65 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • no medical or psychological problems
  • able to come to UCSF for study

You may not qualify if:

  • pregnant or trying to become pregnant
  • Hg \< 10
  • abnormal screening labs
  • anyone unable to follow study directions

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

UCSF

San Francisco, California, 94143, United States

Location

Study Officials

  • lynda frassetto, md

    University of California, San Francisco

    PRINCIPAL INVESTIGATOR
0

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
NONE
Purpose
DIAGNOSTIC
Intervention Model
CROSSOVER
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

April 15, 2014

First Posted

April 17, 2014

Study Start

January 1, 2015

Primary Completion

June 1, 2015

Study Completion

May 1, 2016

Last Updated

July 27, 2017

Record last verified: 2017-07

Locations

US(1)