The Prospective Cohort Study to Investigate the Role of Plasma Triglyceride/High-Density Lipoprotein Cholesterol Ratio To Predict Cardiovascular Outcomes in Chronic Kidney Disease.
Sponsor study identifier
observational
197
1 country
1
Study Start
January 2009
Date type not reportedThis date has not been verified as actual or estimated.
Primary Completion
January 2013
Actual (reported)Study Completion
January 2013
Actual (reported)The Triglycerides (TG) to High Density Lipoprotein Cholesterol (HDL-C) ratio is a feature of insulin resistance and an independent predictor of cardiovascular risk. The investigators aimed to evaluate the relationship between TG/HDL-C ratio and the endothelial functions in patients with CKD.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
January 2013
Actual (reported)Click on a node to explore related trials.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
January 2009
Date type not reportedThis date has not been verified as actual or estimated.
January 2013
Actual (reported)January 2013
Actual (reported)April 9, 2014
Actual (reported)April 14, 2014
Actual (reported)All cause mortality
The COX analysis was performed in order to establish which covariates were independent predictors of cardiovascular outcomes. Kaplan Meier survival curves are generated to show the impact of the TG/HDL ratio on the cumulative survival of the cohort. The predictive power of the median TG/HDL ratio in each CKD stage for all-cause mortality and cardiovascular events are measured.
30 months
Endothelial functions assessed by flow mediated dilatation and serum ADMA measurement
The predictive role of TG/HDL ratio on endothelial functions (ADMA and flow mediated dilatation) is determined by univariate and multivariate analyses.
Once in recruitment
renal unit
Gulhane School of Medicine Department of Endocrinology and Metabolism
Ankara, Ankara, 06018, Turkey (Türkiye)
Sonmez A, Yilmaz MI, Saglam M, Unal HU, Gok M, Cetinkaya H, Karaman M, Haymana C, Eyileten T, Oguz Y, Vural A, Rizzo M, Toth PP. The role of plasma triglyceride/high-density lipoprotein cholesterol ratio to predict cardiovascular outcomes in chronic kidney disease. Lipids Health Dis. 2015 Apr 16;14:29. doi: 10.1186/s12944-015-0031-4.
197 participants (actual enrollment reported by the registry).
First Submitted
April 9, 2014
First Posted
April 14, 2014
Study Start
January 2009
Date type not reportedThis date has not been verified as actual or estimated.
Efficacy and Safety Study of MCI-196 Versus Simvastatin for Dyslipidaemia in Chronic Kidney Disease (CKD) Subjects on Dialysis
Contact the study team to confirm eligibility.
Primary Completion
January 2013
Actual (reported)Study Completion
January 2013
Actual (reported)Last Updated
April 14, 2014
Record last verified: 2014-04
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Source: ClinicalTrials.gov.
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