Immunologic Abnormalities, Chronic Inflammation and Oxidative Stress in Chronic Kidney Disease
1 other identifier
observational
14
1 country
3
Brief Summary
The common causes of mortality are late stages of chronic kidney disease, cardiovascular disease and infections, are associated with abnormalities of the immune system, an underlying state of chronic inflammation and oxidative stress. These processes have not been carefully described in the chronic kidney disease population. The researcher can use Diffuse Optical Spectroscopy to determine the immune system in individuals with chronic kidney disease and describe the association with chronic inflammation and oxidative stress in that population.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for all trials
Started Aug 2008
Typical duration for all trials
3 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
August 1, 2008
CompletedFirst Submitted
Initial submission to the registry
November 14, 2008
CompletedFirst Posted
Study publicly available on registry
November 19, 2008
CompletedPrimary Completion
Last participant's last visit for primary outcome
March 1, 2012
CompletedStudy Completion
Last participant's last visit for all outcomes
March 1, 2012
CompletedOctober 20, 2022
October 1, 2022
3.6 years
November 14, 2008
October 19, 2022
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Medical Tool
Diffuse Optical Spectroscopy measure blood values changes during the hemodialysis treatment.
4 weeks
Study Arms (1)
Medical Tool
Diffuse Optical Spectroscopy measurements will be compared to a variety of laboratory parameters routinely measured in Chronic Inflammation and Oxidative Stress in Chronic Kidney Disease
Interventions
Diffuse Optical Spectroscopy measurements will be compared to a variety of laboratory parameters routinely measured in Chronic Inflammation and Oxidative Stress in Chronic Kidney Disease
Eligibility Criteria
primary care clinic
You may qualify if:
- years and older with chronic kidney disease undergoing hemodialysis have been treated with hemodialysis for at least 3 months
- years and older for control
You may not qualify if:
- acute kidney disease
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (3)
Beckman Laser Institute
Irvine, California, 92612, United States
University of California Medical Center: Dialysis Unit
Orange, California, 92868, United States
UCIMC Dialysis center
Orange, California, 92869, United States
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Madeleine Pahl, M.D.
University of California, Irvine
Study Design
- Study Type
- observational
- Observational Model
- CASE ONLY
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Madeleine Pahl, M.D., Associate Professor of Medicine and Director of the Renal Clinic
Study Record Dates
First Submitted
November 14, 2008
First Posted
November 19, 2008
Study Start
August 1, 2008
Primary Completion
March 1, 2012
Study Completion
March 1, 2012
Last Updated
October 20, 2022
Record last verified: 2022-10