Pseudoexfoliation and Chronic Kidney Disease

NCT01693744 | Completed DMC

• 1 other identifier: LNiyaz
• Study Type: observational
• Target: 358
• Locations: 1 country
• Sites: 1

Brief Summary

Background: Pseudoexfoliation (PEX) is characterised by the deposition of fibrillar material in an eye structures and many other parts of the body including kidneys and blood vessels. As both PEX and chronic kidney disease (CKD) are associated with oxidative stress and endothelial dysfunction we studied if the risk of PEX was increased in patients with CKD. Methods: Patients over age 40 with the diagnosis of CKD were included in the study. Chronic kidney disease was diagnosed as decreased glomerular filtration rate (GFR) of less than 60 mL/min/1.73 m². Study groups were arranged as group 1 consisting of HD receiving patients, group 2 consisting of stage 1-4 CKD patients and group 3 consisting of patients with normal kidney functions (control group). Demographic properties and the rate of PEX were evaluated and compaired between the groups.

Conditions

Chronic Kidney Disease

Keywords

Pseudoexfoliation, chronic kidney disease

Outcome Measures

Primary Outcomes (1)

• Prevalance of pseudoexfoliation in patients with chronic kidney disease

  7 months

Study Arms (3)

Dialysis patients

Patients with stage 5 chronic kidney disease undergoing haemodialysis

Chronic kidney disease patients

Stage 1-4 Chronic kidney disease patients

Control group

Patients with normal renal functions

Eligibility Criteria

• Age: 40 Years - 80 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Patients from nephrology clinic

You may qualify if:

• All patients with chronic kidney disease stage 1-5

You may not qualify if:

• History of eye trauma or surgery

Sponsors & Collaborators

• Corum State Hospital: lead

Study Sites (1)

Corum State Hospital

Çorum, 19000, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Renal Insufficiency, Chronic

Condition Hierarchy (Ancestors)

Renal Insufficiency; Kidney Diseases; Urologic Diseases; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Male Urogenital Diseases; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Leyla Niyaz, M.D.

  Specialist in Ophthalmology

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Ophthalmology Specialist

Study Record Dates

• First Submitted: September 20, 2012
• First Posted: September 26, 2012
• Study Start: October 1, 2011
• Study Completion: April 1, 2012
• Last Updated: September 26, 2012

Record last verified: 2012-09

Locations

TU (1)