Bed-rest, Muscle Mass and Insulin Sensitivity
The Impact of Short-term Bed-rest on Skeletal Muscle Mass and Insulin Sensitivity in Healthy, Young Men
1 other identifier
interventional
15
1 country
1
Brief Summary
In the present study, the effects of 7 days of bed rest on muscle mass, muscle fiber characteristics and insulin sensitivity will be determined.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for not_applicable
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
April 1, 2014
CompletedFirst Posted
Study publicly available on registry
April 9, 2014
CompletedStudy Start
First participant enrolled
June 1, 2014
CompletedPrimary Completion
Last participant's last visit for primary outcome
April 1, 2015
CompletedApril 28, 2015
April 1, 2015
10 months
April 1, 2014
April 27, 2015
Conditions
Outcome Measures
Primary Outcomes (1)
Change in quadriceps muscle cross-sectional area
One day before and directly after cessation of bed rest.
Secondary Outcomes (5)
Change in lower back cross-sectional area
One day before and directly after cessation of bed rest.
Change in leg and whole body lean tissue mass
One day before and directly after cessation of bed rest.
Change in muscle fiber size
One day before and directly after cessation of bed rest.
Change in muscle strength
One day before and directly after cessation of bed rest.
Change in insulin sensitivity
One day before and directly after cessation of bed rest.
Study Arms (1)
Bed rest
EXPERIMENTALOne week of bed rest.
Interventions
Eligibility Criteria
You may qualify if:
- Male
- Aged from 18-35 years
- \< BMI \< 30 kg/m2
You may not qualify if:
- Smoking
- Performing regular resistance training (3+ times per week, carrying out progressive training) in the previous 6 months
- Hypertension (according to WHO criteria) and/or cardiovascular disease
- Any back/leg/knee/neck/postural complaints
- Use of any prescribed medication
- Type 2 diabetes mellitus
- Any family history of thrombosis
- All co-morbidities interacting with mobility and muscle metabolism of the lower limbs (e.g. arthritis, spasticity/rigidity, all neurological disorders and paralysis).
- Myocardial infarction within the last 3 years
- Use of anti-coagulants
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Maastricht University Medical Centre
Maastricht, Netherlands
Related Publications (2)
Dirks ML, Wall BT, van de Valk B, Holloway TM, Holloway GP, Chabowski A, Goossens GH, van Loon LJ. One Week of Bed Rest Leads to Substantial Muscle Atrophy and Induces Whole-Body Insulin Resistance in the Absence of Skeletal Muscle Lipid Accumulation. Diabetes. 2016 Oct;65(10):2862-75. doi: 10.2337/db15-1661. Epub 2016 Jun 29.
PMID: 27358494DERIVEDDirks ML, Backx EM, Wall BT, Verdijk LB, van Loon LJ. May bed rest cause greater muscle loss than limb immobilization? Acta Physiol (Oxf). 2016 Sep;218(1):10-2. doi: 10.1111/apha.12699. Epub 2016 May 20. No abstract available.
PMID: 27124248DERIVED
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Luc JC van Loon, PhD
Maastricht UMC
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- NA
- Masking
- NONE
- Purpose
- BASIC SCIENCE
- Intervention Model
- SINGLE GROUP
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Assistant Professor
Study Record Dates
First Submitted
April 1, 2014
First Posted
April 9, 2014
Study Start
June 1, 2014
Primary Completion
April 1, 2015
Last Updated
April 28, 2015
Record last verified: 2015-04