Tissue and Functional Assessment of Myocardial Injury in Hodgkin Lymphoma (HL) Survivors

NCT02106611 | Completed

• 1 other identifier: 14-017
• Study Type: observational
• Target: 133
• Locations: 1 country
• Sites: 1

Brief Summary

This study will test whether cardiac MRI can improve early detection of Hodgkin lymphoma associated heart disease compared to a stress echocardiogram. By doing both stress echocardiography and cardiac MRI, we will compare the ability of the two tests to detect heart disease.

Conditions

Hodgkin Lymphoma Survivor

Keywords

MRI; stress echo; Clinical Assessment; 14-017

Outcome Measures

Primary Outcomes (1)

• compare the prevalence of cardiac injury

  detected by cardiac MRI to that detected by stress echocardiography among a broadly representative cohort of Hodgkin lymphoma survivors.

  2 years

Study Arms (1)

Hodgkin Lymphoma Survivor

This is a prospective cross-sectional study of 200 HL survivors whose treatment included mediastinal RT at initial diagnosis or relapse, and are at least 5 years from last HL treatment.

Other: Clinical Assessment; Procedure: Stress cardiac MRI; Procedure: Stress echocardiogram

Interventions

Clinical Assessment OTHER

HL treatment will be determined by review of available medical records as archived at MSKCC. Recorded variables will include: (1) RT - field, fractional and cumulative dose, and duration; (2) chemotherapy - regimen, planned interval, dose per cycle, and cumulative dosages. Patients will also be asked to complete the FACT-LYM questionnaire and the FACIT Fatigue questionnaire.

Hodgkin Lymphoma Survivor

Stress cardiac MRI PROCEDURE

Both imaging tests will be performed within a 30 day interval, with the two modalities interpreted by dedicated study investigators blinded to the results of the other modality.

Hodgkin Lymphoma Survivor

Stress echocardiogram PROCEDURE

Both imaging tests will be performed within a 30 day interval, with the two modalities interpreted by dedicated study investigators blinded to the results of the other modality.

Hodgkin Lymphoma Survivor

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

MSKCC

You may qualify if:

• Classical or nodular lymphocyte predominant HL treated at Memorial Sloan-Kettering Cancer Center.
• Age ≥ 18 years
• Treatment for HL that included mediastinal RT at initial diagnosis or relapse.
• ≥ 5 years from last HL treatment.

You may not qualify if:

• Primary HL diagnosis prior to 1980.
• Additional mediastinal RT or subsequent cardiotoxic systemic therapy for secondary malignant neoplasm.
• Known CAD/CHF (defined as documented myocardial infarction, cardiac revascularization, angiographic obstructive CAD, or decreased LV function \[EF \< 55%\] during prior clinical care).
• Contraindication to MRI (i.e. pacemakers, defibrillators, or aneurysm clips, or other implanted ferromagnetic objects), gadolinium (i.e. known hypersensitivity to gadolinium, advanced renal insufficiency as defined by glomerular filtration rate \<30 ml/min/1.73m\^2).
• Contraindication to exercise stress testing other than the above (i.e. unstable angina or severe valvular stenosis).

Sponsors & Collaborators

• Weill Medical College of Cornell University: collaborator
• Memorial Sloan Kettering Cancer Center: lead

Study Sites (1)

Memorial Sloan Kettering Cancer Center

New York, New York, 10065, United States

Location

Related Links

• Memorial Sloan Kettering Cancer Center

Study Officials

• Alison Moskowitz, MD

  Memorial Sloan Kettering Cancer Center

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: April 3, 2014
• First Posted: April 8, 2014
• Study Start: April 1, 2014
• Primary Completion: February 6, 2026
• Study Completion: February 6, 2026
• Last Updated: February 11, 2026

Record last verified: 2026-02

Locations

US (1)