Prognostic Value Cardiac Dysfunction Assessed by Bedside Echocardiography in Critically Ill COPD Patients Requiring Mechanical Ventilation

NCT02099279 | Completed

• 2 other identifiers: echo_COPDecho and COPD
• Study Type: observational
• Target: 53
• Locations: 1 country
• Sites: 1

Brief Summary

Chronic obstructive lung disease (COPD) is a major cause of morbidity and mortality, and is a major reason for ICU admission. Cardiac function is often impaired in this disease but its association with clinical outcome has not been fully established. The study aims to investigate the association between cardiac dysfunction and clinclial outcomes.

Conditions

COPD Patients; Mechanical Ventilation

Outcome Measures

Primary Outcomes (1)

• 28-day mortality

  28 days after ICU admission; if a patient leave ICU before 28-days, it is considered as censored.

  28 days after ICU admission

Secondary Outcomes (1)

• duration of mechanical ventilation

  from ICU admission to extubation, an expected average of 8 days

Study Arms (1)

echocardiography examination

Device: echocardiography examination

Interventions

echocardiography examination DEVICE

patients underwent echocardiography examination

echocardiography examination

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

All patients meeting the diagnostic criteria of AECOPD and admitted to ICU are potentially eligible for the present study. The diagnosis of AECOPD is based on that defined in Global Initiative for Chronic Obstructive Pulmonary Disease. AECOPD is defined using definitive criteria with at least two of the following major symptoms: increased dyspnea, increased sputum purulence, increased sputum volume; or one major and one minor symptom: nasal discharge/congestion, wheeze, sore throat and cough for at least two consecutive days.

You may qualify if:

• COPD patients experiencing episode of exacerbation and require mechanical ventilation were admitted to ICU

You may not qualify if:

• COPD patients admitted to ICU due to other reasons (major surgery, ischemic heart disease, and renal failure)
• moribund and expected to die within 48 hours
• with Do-Not-Resuscitation order

Sponsors & Collaborators

• Jinhua Central Hospital: lead

Study Sites (1)

Jinhua municipal central hospital

Jinhua, Zhejiang, 321000, China

Location

Related Publications (1)

• Zhang Z, Chen L, Chen K, Ni H. The prognostic value of cardiac dysfunction assessed by bedside echocardiography in critically ill patients with COPD requiring mechanical ventilation: a study protocol. BMJ Open. 2014 Sep 25;4(9):e005359. doi: 10.1136/bmjopen-2014-005359.

  PMID: 25256186 DERIVED

Study Officials

• Chen Kun, MB

  Jinhua Municipal Central Hospital

  STUDY CHAIR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: intensivist

Study Record Dates

• First Submitted: March 23, 2014
• First Posted: March 28, 2014
• Study Start: January 1, 2014
• Primary Completion: January 1, 2015
• Study Completion: February 1, 2015
• Last Updated: September 1, 2015

Record last verified: 2014-03

Locations

CN (1)