Decreasing Trigger Sensitivity Could Assist PEEP to Further Improve Regional Ventilation Distribution

NCT03241654 | Completed

• 1 other identifier: KY-2017-001
• Study Type: observational
• Target: 20
• Locations: 1 country
• Sites: 1

Brief Summary

In mechanically ventilated patients during supine position, alveolar collapse usually distributes in dependent lung region.Decrease of flow trigger sensitivity might improve homogeneous of tidal volume distribution.

Conditions

Mechanical Ventilation

Outcome Measures

Primary Outcomes (1)

• The homogeneity of distribution of tidal volume

  EIT was used to monitoring the homogeneity of distribution of tidal volume that was divided into two contiguous regions of interest (ROI) equally, the dependent and non-dependent area. The ratio of relative distribution of tidal ventilation of two ROI was calculated.

  within 20 minutes after changing flow trigger

Secondary Outcomes (1)

• Changes in global and regional EELV

  within 20 minutes after changing flow trigger

Study Arms (2)

the lowest trigger sensitivity

The flow trigger of ventilator was set as the lowest level of sensitivity.

Procedure: flow trigger

the highest trigger sensitivity

The flow trigger of ventilator was set as the highest level of sensitivity.

Procedure: flow trigger

Interventions

flow trigger PROCEDURE

The flow trigger will be adjust during the pressure assist ventilation.

the highest trigger sensitivity; the lowest trigger sensitivity

Eligibility Criteria

• Age: 18 Years - 80 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

The postoperative patients receiving pressure support ventilation and existing heterogenous ventilation.

You may qualify if:

• The post operative patients who received pressure support ventilation;
• After the clinical PEEP was evaluated 5cmH2O, the tidal volume distribution still existed heterogeneity.

You may not qualify if:

• Under 18 years;
• History of diaphragm dysfunction and surgery;
• Central respiratory drive dysfunction;
• history of esophageal, gastric or lung surgery;
• The contraindication of using EIT (pacemaker, defibrillator, and implantable pumps).

Sponsors & Collaborators

• Capital Medical University: lead

Study Sites (1)

Jian-Xin Zhou

Beijing, Beijing Municipality, 100050, China

Location

Study Officials

• Jian-Xin Zhou, MD

  Beijing Tiantan Hospital

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CROSSOVER
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: August 3, 2017
• First Posted: August 7, 2017
• Study Start: May 1, 2017
• Primary Completion: August 20, 2017
• Study Completion: February 1, 2018
• Last Updated: February 12, 2018

Record last verified: 2017-08

Locations

CN (1)