Attention Bias Modification Treatment for Major Depressive Disorder in Adolescents

NCT02078258 | Completed

• 1 other identifier: 1
• Study Type: interventional
• Target: 45
• Locations: 1 country
• Sites: 1

Brief Summary

In this study, we test whether a two-week 8-session neutral attention bias modification (ABM) training and a two-week 4-session positive ABM could reduce depressive symptoms relative to placebo controls in adolescents with major depressive disorder at posttraining and follow-ups during one year.

Conditions

Major Depressive Disorder, Single Episode, Unspecified

Keywords

depression，adolescent，attention bias，modification

Outcome Measures

Primary Outcomes (2)

• Changes in depressive symptom number

  Depressive symptom accounts measured by Kiddie Schedule for Affective Disorders and Schizophrenia for School-Age Children.

  baseline, 7-week, 6-month follow-up

• Changes in depressive severity

  depressive severity measured by the construct interview of the Schedule for Affective Disorders and Schizophrenia for School-Age Children(K-SADS)

  baseline, 7-week, 6-month follow-up

Secondary Outcomes (2)

• Change of Self-report symptoms

  baseline, 7-week, 6-, 12-month follow-up

• Diagnostic status of major depressive disorder

  baseline, 7-week, 6-month follow-up

Study Arms (2)

Attentional bias modification training

EXPERIMENTAL

Attention bias modification training (ABMT) is a a variation of attention tasks to modify attentional biases, in which a probe always appears in the location of relatively positive stimuli after the two stimuli, one neutral and one emotional, were simultaneously presented. Participants complete 8 sessions (320 trials each with 20 minutes) over two weeks of neutral ABMT to shift attention toward neutral, in which a probe appeared in the location of neutral with 90% probability, and sadness-related with 10% probality. At a 9-week follow-up, participants completed 4 more sessions (480 trials each with 30 minutes)over two weeks of positive ABMT to shift attention toward positive words,in which a probe appeared in the location of 67% positive or 33% neutral.

Behavioral: ABMT

Placebo control

ACTIVE COMPARATOR

The placebo ABMT was identical to the active ABMT, but shifted toward neutral (50%) or sad (50%) stimuli equally often (i.e., 50/50 training).

Behavioral: ABMT

Interventions

ABMT BEHAVIORAL

During a two-week period, 8 sessions of a modified dot probe task for attentional bias modification training (ABMT) condition, 8 sessions of a classic dot probe task for placebo training (PT) condition.

Attentional bias modification training; Placebo control

Eligibility Criteria

• Age: 11 Years - 19 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64)

You may qualify if:

• Meet the major depression disorder's criteria

You may not qualify if:

• bipolar disorder, schizophrenia or organic mental disorder;
• any concurrent psychotherapy;
• any concurrent psychotropic medication.

Sponsors & Collaborators

• Hunan Normal University: lead

Study Sites (1)

Department of Psychology, Hunan Normal University

Changsha, Hunan, 400081, China

Location

Related Publications (1)

• Yang W, Zhang JX, Ding Z, Xiao L. Attention Bias Modification Treatment for Adolescents With Major Depression: A Randomized Controlled Trial. J Am Acad Child Adolesc Psychiatry. 2016 Mar;55(3):208-18.e2. doi: 10.1016/j.jaac.2015.12.005. Epub 2015 Dec 23.

  PMID: 26903254 RESULT

MeSH Terms

Conditions

Depressive Disorder, Major

Condition Hierarchy (Ancestors)

Depressive Disorder; Mood Disorders; Mental Disorders

Study Officials

• Wenhui Yang, Ph.D, MD.

  Hunan Normal University

  STUDY DIRECTOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: TRIPLE
• Who Masked: PARTICIPANT, INVESTIGATOR, OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Department of Psychology

Study Record Dates

• First Submitted: January 14, 2014
• First Posted: March 5, 2014
• Study Start: September 1, 2012
• Primary Completion: January 1, 2014
• Study Completion: July 1, 2015
• Last Updated: March 28, 2019

Record last verified: 2019-03

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL, SAP, CSR, ANALYTIC CODE
• Time Frame: after the completion and forever
• Access Criteria: Only for research

Locations

CN (1)