Effects of Aerobic Exercise on Cognitive Function and Brain-derived Neurotrophic Factor in Young Adults
1 other identifier
interventional
130
1 country
1
Brief Summary
The present study will investigate the effects of aerobic exercise on cognition and growth factors including brain-derived neurotrophic factor (BDNF) in young adults aged 15-21 years. The included subjects will be randomized to three different groups including one control group and two exercise groups. Subjects randomized to the exercise groups will complete 30 minutes of aerobic exercise 3 times a week for 9 weeks incorporating low (group I) or high (group II) intensity aerobic exercise. The exercise will be conducted as running or indoor cycling (supervised). At baseline and 9-weeks follow-up all subjects will complete two cognitive tests (measures of concentration and sustained attention), a maximal cycling test (direct measures of VO2max), an intelligence quotient test, anthropometric measures, fasting blood samples and blood samples immediately following the cycling test. The blood samples will be analyzed for growth factors including BDNF and metabolic factors.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for not_applicable
Started Feb 2014
Shorter than P25 for not_applicable
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
February 1, 2014
CompletedFirst Submitted
Initial submission to the registry
February 27, 2014
CompletedFirst Posted
Study publicly available on registry
March 3, 2014
CompletedPrimary Completion
Last participant's last visit for primary outcome
June 1, 2014
CompletedStudy Completion
Last participant's last visit for all outcomes
June 1, 2014
CompletedJune 26, 2014
June 1, 2014
4 months
February 27, 2014
June 25, 2014
Conditions
Keywords
Outcome Measures
Primary Outcomes (3)
The Flanker Task
9 weeks
The AX-Continuous Performance test
9 weeks
Brain-derived neurotrophic factor
9 weeks
Secondary Outcomes (1)
Intelligence quotient
9 weeks
Study Arms (3)
High intensity aerobic exercise
EXPERIMENTAL30 minutes of high intensity aerobic exercise 3 times a weeks for 9 weeks - incorporation interval training
Low intensity aerobic exercise
EXPERIMENTAL30 minutes of low intensity aerobic exercise 3 times a weeks for 9 weeks
Control
NO INTERVENTIONNo intervention. Participants are told not to make any changes in their everyday life
Interventions
Eligibility Criteria
You may qualify if:
- age 15-21
You may not qualify if:
- injury preventing one from being physically active
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
University of Southern Denmark
Odense, 5000, Denmark
Related Publications (1)
Gejl AK, Bugge A, Ernst MT, Mortensen EL, Gejl KD, Andersen LB. Effects of 9 Weeks of High- or Moderate-Intensity Training on Cardiorespiratory Fitness, Inhibitory Control, and Plasma Brain-Derived Neurotrophic Factor in Danish Adolescents-A Randomized Controlled Trial. Scand J Med Sci Sports. 2024 Aug;34(8):e14703. doi: 10.1111/sms.14703.
PMID: 39054765DERIVED
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Anne K Thorsen, Cand. Scient
University of Southern Denmark
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- SINGLE
- Who Masked
- INVESTIGATOR
- Purpose
- SUPPORTIVE CARE
- Intervention Model
- FACTORIAL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- PhD
Study Record Dates
First Submitted
February 27, 2014
First Posted
March 3, 2014
Study Start
February 1, 2014
Primary Completion
June 1, 2014
Study Completion
June 1, 2014
Last Updated
June 26, 2014
Record last verified: 2014-06