NCT02070536|Completed
Predictive Values of Plasma Soluble RAGE Levels and RAGE Polymorphisms for the Onset of Acute Respiratory Distress Syndrome in Critically Ill Patients
PrediRAGE
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PrediRAGE
Sponsor study identifier
observational
500
1 country
1
Study Start
February 2014
Actual (reported)Primary Completion
March 2016
Actual (reported)Study Completion
December 2016
Actual (reported)Current clinical prediction scores for acute respiratory distress syndrome (ARDS) have limited positive predictive value. No studies have evaluated predictive kinetics of plasma biomarkers and receptor for advanced glycation end products (RAGE) polymorphisms in a broad population of critically ill patients or as an adjunct to clinical prediction scores. The main objective of the investigators study is to evaluate the predictive values of plasma soluble RAGE levels for the onset of ARDS in a high risk population of patients admitted to the intensive care unit (ICU). One of the investigators goals is to improve early identification of patients at risk for ARDS in order to better implement preventive stategies prior to ARDS development. The primary outcome is the occurrence of ARDS during the first week after admission to the ICU.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
December 2016
Actual (reported)Click on a node to explore related trials.
Some registry-reported names shown below are not yet linked in this graph.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
February 2014
Actual (reported)February 21, 2014
Actual (reported)February 25, 2014
Actual (reported)March 2016
Actual (reported)December 2016
Actual (reported)development of ARDS
The development of ARDS, based on Berlin definition criteria, during the first week after admission to the ICU
during the first week after admission to the ICU
Plasma sRAGE and esRAGE levels
at ICU admission (Day 0)
Plasma sRAGE and esRAGE levels
(Day 1)
Evolution of plasma sRAGE levels
between day 0 and day 1
Maximal plasma levels of sRAGE and esRAGE
during the first 24 hours after ICU admission
Development of ARDS
during at day 14 and day 30 after ICU admission
Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.
Population at high risk for ARDS development
CHU de Clermont-Ferrand
Clermont-Ferrand, 63003, France
Blondonnet R, Joubert E, Godet T, Berthelin P, Pranal T, Roszyk L, Chabanne R, Eisenmann N, Lautrette A, Belville C, Cayot S, Gillart T, Souweine B, Bouvier D, Blanchon L, Sapin V, Pereira B, Constantin JM, Jabaudon M. Driving pressure and acute respiratory distress syndrome in critically ill patients. Respirology. 2019 Feb;24(2):137-145. doi: 10.1111/resp.13394. Epub 2018 Sep 5.
Pranal T, Pereira B, Berthelin P, Roszyk L, Godet T, Chabanne R, Eisenmann N, Lautrette A, Belville C, Blondonnet R, Cayot S, Gillart T, Skrzypczak Y, Souweine B, Bouvier D, Blanchon L, Sapin V, Constantin JM, Jabaudon M. Clinical and Biological Predictors of Plasma Levels of Soluble RAGE in Critically Ill Patients: Secondary Analysis of a Prospective Multicenter Observational Study. Dis Markers. 2018 May 10;2018:7849675. doi: 10.1155/2018/7849675. eCollection 2018.
Matthieu JABAUDON
University Hospital, Clermont-Ferrand
500 participants (actual enrollment reported by the registry).
First Submitted
February 21, 2014
First Posted
February 25, 2014
Study Start
February 2014
Actual (reported)Efficacy of Sound Insulation and Music Therapy on the Comfort of Mechanically Ventilated Patients Admitted to Intensive Care Unit
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Primary Completion
March 2016
Actual (reported)Study Completion
December 2016
Actual (reported)Last Updated
May 12, 2020
Record last verified: 2014-02
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Source: ClinicalTrials.gov.
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