The Influence of Different Concentrations of Glucose in Culture Media on In Vitro Fertilization (IVF) Outcome of Sibling Oocytes
1 other identifier
observational
600
1 country
1
Brief Summary
The importance of glucose in culture media on fertilization and embryo development is still controversial. Although it has been reported that glucose is essential for fertilization process and biosynthesis of membrane lipid and nucleic acids, comparatively high levels of glucose in culture media may cause developmental arrest of cleavage stage embryos. The aim of this retrospective study is to examine whether exposure of sibling oocytes to different concentrations of glucose in culture media has any further effect on IVF outcome.
Trial Health
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participants targeted
Target at P75+ for all trials
Started Apr 2014
1 active site
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Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
February 16, 2014
CompletedFirst Posted
Study publicly available on registry
February 19, 2014
CompletedStudy Start
First participant enrolled
April 1, 2014
CompletedPrimary Completion
Last participant's last visit for primary outcome
April 1, 2016
CompletedStudy Completion
Last participant's last visit for all outcomes
April 1, 2016
CompletedFebruary 19, 2014
February 1, 2014
2 years
February 16, 2014
February 18, 2014
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Fertilization Rate
Fertilization rates will be retrospectively compared according to culture media in which sibling oocytes were incubated
2 years
Secondary Outcomes (1)
Embryo Quality
2 years
Study Arms (4)
Universal IVF Medium
An oocyte culture medium containing 5.55 Mm glucose (Origio, Medi-Cult)
ISM1 Medium
An oocyte culture medium containing 1mM glucose ((Origio, MediCult)
P1 Medium
An oocyte culture medium containing no glucose (Irvine)
ECM Medium
An oocyte culture medium containing 0.5mM glucose (Irvine)
Interventions
Eligibility Criteria
Sibling oocytes retrieved from women who have undergone IVF treatment in our IVF unit.
You may qualify if:
- Sibling oocytes from cycles where at least 4 oocytes were retrieved
You may not qualify if:
- Less than 4 oocytes retrieved
- Partner has undergone testicular sperm extraction (TESE)
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Hillel Yaffe Medical Center
Hadera, 38100, Israel
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Medeia Michaelo, PhD
Hellel Yaffe Medical Center
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- RETROSPECTIVE
- Sponsor Type
- OTHER GOV
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
February 16, 2014
First Posted
February 19, 2014
Study Start
April 1, 2014
Primary Completion
April 1, 2016
Study Completion
April 1, 2016
Last Updated
February 19, 2014
Record last verified: 2014-02