High Intensity Cycling Before SCUBA Diving Reduces Post-decompression Microparticle Production and Neutrophil Activation
1 other identifier
interventional
10
2 countries
2
Brief Summary
The purpose of this study is to determine the impact of high intensity,anaerobic exercise, in the form of cycling, on SCUBA diving. Outcomes are determined by the quantification and subtype of circulating microparticles, complete blood counts, and the quantification of venous gas emboli, measured via transthoracic echocardiography, in the cardiac cavities.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for not_applicable
Started Feb 2013
Shorter than P25 for not_applicable
2 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
February 1, 2013
CompletedPrimary Completion
Last participant's last visit for primary outcome
May 1, 2013
CompletedStudy Completion
Last participant's last visit for all outcomes
May 1, 2013
CompletedFirst Submitted
Initial submission to the registry
February 12, 2014
CompletedFirst Posted
Study publicly available on registry
February 17, 2014
CompletedFebruary 17, 2014
February 1, 2014
3 months
February 12, 2014
February 13, 2014
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Change from baseline values of number of circulating microparticles per microliter of blood
Prior to exercise, prior to diving, 15 and 120 minutes after surfacing
Study Arms (1)
High intensity exercise
EXPERIMENTALA dive to 18 meters sea water for a duration of 41 minutes preceded by high intensity cycling
Interventions
Subjects performed a repeated Wingate protocol for the exercise condition of the study. This consisted of 4, 30 s maximal efforts on a weight-braked cycle ergometer (Monark 894E, Monark Exercise AB, Sweden) with 4 min active recovery between efforts, preceded by a 5 min warm up. The resistance was set at 7.5% bodyweight for the intervals and 2% for the warm up and active recovery periods.
Eligibility Criteria
You may qualify if:
- Experienced divers (\> 250 logged dives)
- Male
- Physician clearance to dive
You may not qualify if:
- Prior incidence of decompression sickness
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- University of Splitlead
- University of Marylandcollaborator
Study Sites (2)
University of Maryland
Baltimore, Maryland, 21201, United States
University of Split School of Medicine
Split, Dalmatia, 21000, Croatia
Related Publications (1)
Thom SR, Milovanova TN, Bogush M, Yang M, Bhopale VM, Pollock NW, Ljubkovic M, Denoble P, Madden D, Lozo M, Dujic Z. Bubbles, microparticles, and neutrophil activation: changes with exercise level and breathing gas during open-water SCUBA diving. J Appl Physiol (1985). 2013 May 15;114(10):1396-405. doi: 10.1152/japplphysiol.00106.2013. Epub 2013 Mar 14.
PMID: 23493363BACKGROUND
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Zeljko Dujic, MD. PhD
University of Split
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- NA
- Masking
- NONE
- Purpose
- BASIC SCIENCE
- Intervention Model
- SINGLE GROUP
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Professor Zeljko Dujic MD, PhD
Study Record Dates
First Submitted
February 12, 2014
First Posted
February 17, 2014
Study Start
February 1, 2013
Primary Completion
May 1, 2013
Study Completion
May 1, 2013
Last Updated
February 17, 2014
Record last verified: 2014-02