Optical Coherence Tomography (OCT) in Uveitis

NCT02026128 | Recruiting

• 1 other identifier: OHSU IRB#00008052
• Study Type: observational
• Target: 75
• Locations: 1 country
• Sites: 1

Brief Summary

Optical Coherence Tomography (OCT) machines are non-contact instruments that can provide micrometer (one one-thousandths) scale imaging of biological tissue. This allows excellent assessment of the white blood and inflammatory cells seen in uveitis, an inflammation of any or all parts of the uvea (iris, ciliary body, choroid).

Conditions

Uveitis

Keywords

Uveitis; Inflammation; OCT; Grading

Outcome Measures

Primary Outcomes (4)

• Number of anterior chamber cells

  Anterior chamber cells will be identified from OCT images by computer algorithms. Anterior chamber cells will be measured in particles.

  1 month

• Number of keratic precipitates (KP)

  KPs will be identified from OCT images by computer algorithms. KPs will be measured in particles.

  1 month

• Number of vitreous cells

  Vitreous cells will be identified from OCT images by computer algorithms. Vitreous cells will be measured in particles.

  1 month

• Degree of anterior chamber flare

  OCT signal of the aqueous humor will be analyzed and correlated with slit lamp grades on AC flare. AC flare will be measured in a.u.

  1 month

Study Arms (1)

Active Uveitis

Physician-confirmed diagnosis of uveitis of any origin.

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

The study will enroll both males and females and include all ethnic and racial groups through clinical practices. The study will enroll subjects 18 years of age or older with physician-confirmed, active uveitis. A total of thirty subjects will be recruited.

You may qualify if:

• years of age and older
• With one or more of the following clinical features:
• \>1+ AC cells;
• \>1+ vitreous haze;
• presence of vitreous cells;
• presence of blood in anterior chamber;
• presence of blood in vitreous;
• presence of aqueous or vitreous pigment.
• In one of the following diagnostic categories as determined by a uveitis specialists:
• uveitis due to ankylosing spondylitis (positive HLA B27 genotype);
• uveitis due to sarcoidosis;
• uveitis of any additional type;
• uveitis masquerade such as pigment dispersion syndrome or Schaffer's sign;
• hyphema due to trauma or other causes;
• vitreous hemorrhage;

You may not qualify if:

• Inability to give informed consent;
• Inability to maintain stable fixation for OCT imaging.

Sponsors & Collaborators

• Oregon Health and Science University: lead

Study Sites (1)

Oregon Health & Science University

Portland, Oregon, 97239, United States

RECRUITING

MeSH Terms

Conditions

Uveitis; Inflammation

Condition Hierarchy (Ancestors)

Uveal Diseases; Eye Diseases; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• David Huang, MD, PhD

  Oregon Health and Science University

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Denny Romfh, OD

CONTACT

503-494-4351; romfhd@ohsu.edu

Humberto Martinez, COT

CONTACT

503-494-7712; martinhu@ohsu.edu

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: David Huang, MD, PhD, Professor of Ophthalmology & Director of Research, Casey Eye Institute OHSU

Study Record Dates

• First Submitted: December 30, 2013
• First Posted: January 1, 2014
• Study Start: March 1, 2012
• Primary Completion: December 1, 2025
• Study Completion: December 1, 2025
• Last Updated: February 12, 2024

Record last verified: 2024-02

Locations

US (1)