Uveitis Gene-Expression Profiling

NCT00874471 | Completed

• 1 other identifier: R01EY015858
• Study Type: observational
• Target: 280
• Locations: 1 country
• Sites: 1

Brief Summary

Uveitis is a group of troublesome diseases that collectively represent a cause of blindness comparable to diabetes. Most forms of uveitis are either infectious or immune-mediated. The investigators propose to create a data base on peripheral blood gene expression for patients with 3 of the most important diseases associated with uveitis: ankylosing spondylitis, sarcoidosis, and Behcet's disease. The investigators will quantitatively measure the expression of consistent alteration in peripheral blood from patients with more than 40,000 gene sequences using microarray gene chip technology. This approach is known to detect systemic immune-mediated disease. The investigators will use this data base to:

1. 1.Determine if patients with uveitis and ankylosing spondylitis, sarcoidosis, or Behcet's can be distinguished from a normal population or controls with the same systemic disease but no history of uveitis
2. 2.Determine if the profile of gene expression can distinguish infectious or idiopathic forms of uveitis from patients with spondylitis, sarcoidosis, or Behcet's
3. 3.Determine how this gene profile changes over time as episodic disease such as spondylitis or Behcet's activates or remits
4. 4.Correlate the changes in gene expression with the prognosis of the ocular inflammatory process.

Conditions

Uveitis

Outcome Measures

Primary Outcomes (1)

• Correlation of blood transcriptome with form of uveitis

  time of office visit for disease evaluation

Study Arms (10)

sarcoidosis

ankylosing spondylitis

Behcet's disease

toxoplasmosis

herpetic acute retinal necrosis

idiopathic uveitis

ankylosing spondylitis (no uveitis)

sarcoidosis (no uveitis)

Behcet's disease (no uveitis)

normal control

Eligibility Criteria

• Age: 21 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Individuals suffering from selected subtypes of uveitis, individuals suffering from selected autoimmune disease and healthy individuals.

You may qualify if:

• The study group will include patients aged 21 years or older attending the Uveitis Clinic at the Casey Eye Institute at OHSU who have uveitis of the following subtypes:
• ankylosing spondylitis
• sarcoidosis
• Behçet's disease
• toxoplasmosis
• herpetic acute retinal necrosis; AND
• idiopathic uveitis
• Another group of patients, also aged 21 years or more, with the following diseases but no uveitis, will be recruited from the Rheumatology Clinic at OHSU as follows:
• ankylosing spondylitis
• sarcoidosis; AND
• Behçet's disease
• The study group will also include 30 normal control volunteers aged 21 years or older.

You may not qualify if:

• Special/vulnerable subject populations (e.g., mentally impaired persons and children) will not be enrolled.

Sponsors & Collaborators

• Oregon Health and Science University: lead

Study Sites (1)

Oregon Health & Science University

Portland, Oregon, 97239-3098, United States

Location

MeSH Terms

Conditions

Uveitis

Condition Hierarchy (Ancestors)

Uveal Diseases; Eye Diseases

Study Officials

• James Rosenbaum, MD

  Oregon Health and Science University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: April 1, 2009
• First Posted: April 2, 2009
• Study Start: June 1, 2005
• Primary Completion: July 1, 2010
• Last Updated: April 9, 2014

Record last verified: 2014-04

Locations

US (1)