Evaluation of GCF MMP-1, -8 and Growth Factor Levels in Smokers With Periodontal Health
1 other identifier
observational
32
1 country
1
Brief Summary
Increased levels of cytokines in GCF have been demonstrated in smoker subjects with chronic periodontitis. It is not surprising that increased levels of inflammation associated molecules in GCF has been observed in smokers with periodontitis. However, it is not clear if smoking has an influence on these parameters in periodontally healthy individuals. In the present study, it has been hypothesized that smoking might affect the levels of GCF MMPs and growth factors in young adults with periodontal health.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for all trials
Started May 2012
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
May 1, 2012
CompletedPrimary Completion
Last participant's last visit for primary outcome
September 1, 2013
CompletedStudy Completion
Last participant's last visit for all outcomes
September 1, 2013
CompletedFirst Submitted
Initial submission to the registry
December 10, 2013
CompletedFirst Posted
Study publicly available on registry
December 18, 2013
CompletedDecember 18, 2013
December 1, 2013
1.3 years
December 10, 2013
December 12, 2013
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
GCF levels of MMP-1, MMP-8, TGF-β1, VEGF and PDGF-AB
Total amount and concentration of these biomarkers in GCF
Baseline
Study Arms (2)
Periodonatlly healthy smokers
Gingival crevicular fluid sampling
Periodontally healhty non-smokers
Gingival crevicular fluid sampling
Interventions
Eligibility Criteria
Dental faculty students
You may qualify if:
- Periodontally and systemically healthy individuals
- Have at least 20 teeth
- \>10 cigarettes/day consumption for smoker group
- Non-smokers subjects were selected from periodontally healthy participants who had never smoked.
You may not qualify if:
- Any health condition affecting their systemic status such as diabetes mellitus, immunologic disorders, human immunodeficiency virus infections, hepatitis were excluded
- Also pregnant and lactating women and those taking oral contraceptive drugs were not included in the study.
- Any antibiotic intake within the last 3 months and any periodontal treatment within 6 months
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Ege Universitylead
Study Sites (1)
Ege University School of Dentistry Department of Periodontology
Izmir, 35100, Turkey (Türkiye)
Biospecimen
Gingival crevicular fluid
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- STUDY DIRECTOR
Gul Atilla, Professor
Ege University School of Dentistry
- STUDY CHAIR
Hatice Oya Turkoglu, Assoc. Professor
Ege University School of Dentistry
- STUDY CHAIR
Harika Atmaca, PhD
Celal Bayar University
Study Design
- Study Type
- observational
- Observational Model
- CASE CONTROL
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Research Assistant
Study Record Dates
First Submitted
December 10, 2013
First Posted
December 18, 2013
Study Start
May 1, 2012
Primary Completion
September 1, 2013
Study Completion
September 1, 2013
Last Updated
December 18, 2013
Record last verified: 2013-12