Effects of Panax Ginseng and Salvia Miltiorrhiza Supplementation on Vascular Function

NCT02007304 | Unknown

• 1 other identifier: 201112068MIB
• Study Type: interventional
• Target: 48
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of is to determine the preventive effects of Chinese herb supplement with panax ginseng and salvia miltiorrhiza prior to eccentric resistance exercise on arterial stiffness and vascular reactivity by using a double-blind randomized control design and to examine the effects of a 12-week progressive eccentric resistance exercise training on arterial elasticity and vascular reactivity, and whether a long-term supplementation would ameliorate arterial stiffening effects elicited by exercise-induced inflammation and improve endothelial function.

Conditions

Healthy

Outcome Measures

Primary Outcomes (3)

• Pulse Wave Velocity

  PWV will be measured before, 6th week, 12th week of eccentric exercise training.

  Before eccentric exercise and training

• Pulse Wave Velocity

  PWV will be measured before, 6th week, 12th week of eccentric exercise training.

  6th week of eccentric exercise traininig

• Pulse Wave Velocity

  PWV will be measured before, 6th week, 12th week of eccentric exercise training.

  12th week of eccentric exercise training

Secondary Outcomes (3)

• Blood pressure

  Before intervention

• Blood pressure

  6th week of intervention

• Blood pressure

  12th week of intervention

Study Arms (2)

Herbs

EXPERIMENTAL

participants assigned to experimental arm will take 300mg panax ginseng and 300mg salvia miltiorrhiza extracts in capsules for 12 weeks along with eccentric exercise training

Behavioral: Eccentric exercise training

Placebo

PLACEBO COMPARATOR

parcipants in this group will take placebo capsule containing microcrystalline cellulose

Behavioral: Eccentric exercise training

Interventions

Eccentric exercise training BEHAVIORAL

12 weeks of lower leg eccentric training

Herbs; Placebo

Eligibility Criteria

• Age: 20 Years - 60 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Healthy sedentary adults

You may not qualify if:

• obesity (BMI \>30 kg/m2)
• smoking within past six months
• hypertension (high blood pressure \>140/90 mmHg)
• personal history of diabetes (fasting blood glucose \>126 mg/dL), heart disease, or other cardiovascular problems
• orthopedic injury that may prevent him or her from completing the exercise
• the use of over-the-counter supplements or vitamins

Sponsors & Collaborators

• National Taiwan University Hospital: lead

Study Sites (1)

National Taiwan University

Taipei, 106, Taiwan

RECRUITING

Related Publications (2)

• Lin HF, Chou CC, Chao HH, Tanaka H. Panax ginseng and Salvia miltiorrhiza supplementation during eccentric resistance training in middle-aged and older adults: A double-blind randomized control trial. Complement Ther Med. 2016 Dec;29:158-163. doi: 10.1016/j.ctim.2016.10.003. Epub 2016 Oct 11.

  PMID: 27912940 DERIVED

• Lin HF, Tung K, Chou CC, Lin CC, Lin JG, Tanaka H. Panax ginseng and salvia miltiorrhiza supplementation abolishes eccentric exercise-induced vascular stiffening: a double-blind randomized control trial. BMC Complement Altern Med. 2016 Jun 6;16:168. doi: 10.1186/s12906-016-1139-4.

  PMID: 27266702 DERIVED

Study Officials

• Hsin-Fu Lin, Ph.D

  National Taiwan University

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Hsin-Fu Lin, Ph.D.

CONTACT

+886932873163; hsinfu@ntu.edu.tw

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: QUADRUPLE
• Who Masked: PARTICIPANT, CARE PROVIDER, INVESTIGATOR, OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: December 4, 2013
• First Posted: December 10, 2013
• Study Start: November 1, 2012
• Primary Completion: July 1, 2014
• Last Updated: December 10, 2013

Record last verified: 2013-12

Locations

TW (1)