Effect of Low-carbohydrate/High-fat Diet on Glucose Tolerance and Lipid Profile in Lean, Healthy Women

NCT02005224 | Completed DMC

• 1 other identifier: AMUC-NIH-LCHF-P1-2012
• Study Type: interventional
• Target: 17
• Locations: 1 country
• Sites: 1

Brief Summary

Intervention studying the effect of a low-carbohydrate/high-fat (LCHF) diet as well as on bout of exercise in combination with either a normal diet or a LCHF diet, in relation to glucose metabolism, insulin sensitivity, lipid profile and body composition.

Conditions

Insulin Sensitivity; Weight

Keywords

Insulin sensitivity; Lipid profile; Body composition; Weight

Outcome Measures

Primary Outcomes (1)

• Area under the curve glucose (0, 15, 30, 45, 60, 90 and 120 min)

  performed by oral glucose tolerance test, 75 g glucose, 300 ml water

  -1 week, 3 weeks

Study Arms (1)

LCHF diet and a bout of exercise

OTHER

LCHF diet for 3 weeks, where E% 70 fat, E% 20-25 proteins and 20g or less carbohydrates. Oral glucose tolerance test on the morning of day 21 followed by a bout of exercise in the afternoon (indoor bicycle, 60min at 75% HFpeak). The following morning (day 22) a new oral glucose tolerance test. Oral glucose tolerance test results from pre-tests used to determine the effect of LCHF and a bout of exercise on insulin sensitivity.

Other: LCHF diet and a bout of exercise

Interventions

LCHF diet and a bout of exercise OTHER

Low-carbohydrate/high-fat diet; effect on insulin sensitivity, lipid profile, weight and body composition. Participants ingested LCHF diet for three weeks before undergoing an oral glucose tolerance test. The same afternoon the participated in an one hour indoor bicycle training at 75% at HFpeak. The following morning they underwent a new oral glucose tolerance test. Body composition and weight were measured before and after the intervention. Oral glucose tolerance test was also performed before the intervention for baseline. Blood samples were collected before and after the intervention for lipid profile analyses.

LCHF diet and a bout of exercise

Eligibility Criteria

• Age: 18 Years - 30 Years
• Sex: female
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Females
• Normal weight
• BMI between 18.5 and 25
• Moderately trained

You may not qualify if:

• Smokers/tobacco users
• pregnancy
• familial cardio-vascular-disease
• diabetes or reduced glucose tolerance
• under- or overweight (BMI under 18.5 or over 25)
• top athletes

Sponsors & Collaborators

• Atlantis Medical University College: lead
• Norwegian School of Sport Sciences: collaborator

Study Sites (1)

Norwegian School of Sport Sciences

Oslo, 0806, Norway

Location

MeSH Terms

Conditions

Insulin Resistance; Body Weight

Condition Hierarchy (Ancestors)

Hyperinsulinism; Glucose Metabolism Disorders; Metabolic Diseases; Nutritional and Metabolic Diseases; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Officials

• Jorgen Jensen, PhD

  Norwegian School of Sport Sciences - Department of Physical Performance

  STUDY DIRECTOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: PREVENTION
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: December 4, 2013
• First Posted: December 9, 2013
• Study Start: August 1, 2012
• Primary Completion: November 1, 2012
• Study Completion: March 1, 2013
• Last Updated: December 9, 2013

Record last verified: 2013-12

Locations

NO (1)