UCLA Fitness and Memory Study of Activity In Mild Cognitive Impairment (AIM)

NCT02001441 | Completed

• 2 other identifiers: 13-000781UL1TR000124
• Study Type: observational
• Target: 35
• Locations: 1 country
• Sites: 1

Brief Summary

This project will examine the relationship between physical activity levels, brain structure and memory function in adults with Mild Cognitive Impairment (MCI) aged 60 to 75. The study will follow 30 adults with age-associated memory impairment or MCI over the course of 18 months. During this time, subjects' physical activity levels will be measured regularly and related to both the thickness their hippocampus and to their memory performance. Subjects will be recruited and screened for major health problems at UCLA. Physical activity will be tracked for two weeks using accelerometers at baseline and every 6 months during the study. At baseline and at the end of the study, subjects will undergo a structural MRI brain scan to measure hippocampal thickness, as well as a neuropsychological evaluation to measure memory function. The study will seek to determine the relationship between physical activity level, hippocampal thickness and memory performance in older adults with age-associated memory impairment.

Conditions

Mild Cognitive Impairment

Keywords

Physical Activity, Aging, Memory, Cognitive Impairment, MRI, Neuroscience

Outcome Measures

Primary Outcomes (1)

• Activity level correlation with hippocampal thickness

  Correlation of activity levels, as measured using ankle accelerometers, with hippocampal thickness, as measured using brain Magnetic Resonance Imaging (MRI).

  18 months

Secondary Outcomes (1)

• Activity level correlation with memory performance

  18 months

Other Outcomes (2)

• Baseline measures prediction of follow-up measures

  18 months

• Activity level correlation with other measures controlling for other factors

  18 months

Study Arms (1)

No treatment

Eligibility Criteria

• Age: 60 Years - 89 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Southern California Residents with memory complaints aged 60-89.

You may qualify if:

• Agreement to participate in the study
• years of age
• Diagnostic criteria for Mild Cognitive Impairment diagnosis: subjective memory complaints, Montreal Cognitive Assessment score of \<26, intact instrumental activities of daily living (Smith et al., 1996) OR subjective age-associated memory complaints
• Cohabitation with an adult capable of ensuring correct usage of the physical activity monitors during the study and verifying self-reports of activity levels.
• Adequate visual and auditory acuity to allow neuropsychological testing.
• Screening laboratory tests and EKG without significant abnormalities that might interfere with the study. If screening laboratory tests or EKG show abnormalities, PI may request clearance from primary care physician before subject continues in study.

You may not qualify if:

• Comorbid conditions impacting mobility
• Current, untreated depression: BDI-II score \>13
• Diagnosis of probable Alzheimer's disease (AD) or any other dementia (e.g., vascular, Lewy body, frontotemporal).
• Evidence of other neurological or physical illness that can produce cognitive deterioration. Volunteers with a history of head trauma, stroke, TIA, carotid bruits, or lacunes on MRI scans will be excluded.
• Contraindication to the MRI including claustrophobia, metal in body, surgery within 60 days, certain medical implants or previous abnormal MRI results.
• History of cardiovascular disease
• Uncontrolled hypertension (systolic BP \> 170 or diastolic BP \> 100)
• Current diagnosis of any major psychiatric disorder according to the DSM-IV TR criteria (APA, 2000), including current alcoholism or substance addiction.
• Current use of marijuana
• Previous use of marijuana for at least 15 days in a month, initiating use during adolescence and continuing for at least one year

Sponsors & Collaborators

• University of California, Los Angeles: lead

Study Sites (1)

UCLA Longevity Center

Los Angeles, California, 90095, United States

Location

Related Links

• Longevity Center Research Laboratory

Biospecimen

Retention: SAMPLES WITH DNA

Whole blood

MeSH Terms

Conditions

Cognitive Dysfunction; Motor Activity

Condition Hierarchy (Ancestors)

Cognition Disorders; Neurocognitive Disorders; Mental Disorders; Behavior

Study Officials

• David Merrill, MD, PhD

  University of California, Los Angeles

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professor

Study Record Dates

• First Submitted: November 27, 2013
• First Posted: December 4, 2013
• Study Start: August 1, 2013
• Primary Completion: August 1, 2015
• Study Completion: August 1, 2015
• Last Updated: May 2, 2018

Record last verified: 2018-04

Locations

US (1)