Model-Based Image Reconstruction for X-Ray CT in Lung Imaging

NCT01979991 | Completed Phase 1 DMC

• 1 other identifier: HUM00038447
• Study Type: interventional
• Target: 184
• Locations: 1 country
• Sites: 1

Brief Summary

To develop a computer program that will improve CT image quality and decrease the amount of x-ray radiation that future patients may be exposed to when they have a CT examination.

Conditions

Lung Diseases

Outcome Measures

Primary Outcomes (1)

• Developement of a computer program to improve CT image quality

  Sinograms will be retrieved by an archive system and processed by MBIR (model-based image reconstruction) methods that we are developing that improve image quality (reduce noise, improve spatial resolution, reduce artifacts). We will evaluate the image quality both quantitatively and qualitatively. We hope to develop and benchmark methods for algorithm acceleration to enable routine clinical use of MBIR (model-based image reconstruction) methods.

  6 years

Study Arms (1)

CT Imaging and Reconstruction

EXPERIMENTAL

To develop a MBIR (model-based image reconstruction) method that will improve X-ray CT lung imaging by improving image quality and reducing dose.

Procedure: CT Imaging and Reconstruction

Interventions

CT Imaging and Reconstruction PROCEDURE

Patients will be consented for their permission to save and use the sinogram from their CT chest/lung scan. The sinogram will be de-identified and sent to an archive system for storage. Later it will be exported to a computer for processing using MBIR (model based image reconstruction). The newly processed images will then be read by blinded readers. The quality of the images will be reviewed to determine if they are as readable and accurate as CT images created with the software that is currently being used.

CT Imaging and Reconstruction

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• \. 18 years of age and older 2. No medical or psychiatric condition precluding informed consent

You may not qualify if:

• Inability to lie flat on the back with arms raised over the head for 30min.
• Metallic implants or metallic devices in the chest or back.
• Participation in other research trials involving ionizing radiation

Sponsors & Collaborators

• University of Michigan: lead
• National Institutes of Health (NIH): collaborator
• General Electric: collaborator

Study Sites (1)

University of Michigan Hospital

Ann Arbor, Michigan, 48109, United States

Location

MeSH Terms

Conditions

Lung Diseases

Interventions

Plastic Surgery Procedures

Condition Hierarchy (Ancestors)

Respiratory Tract Diseases

Intervention Hierarchy (Ancestors)

Surgical Procedures, Operative

Study Officials

• Jeffrey Fessler, PhD

  University of Michigan Hospital

  PRINCIPAL INVESTIGATOR

• Jeffrey Fessler, PhD

  University of Michigan

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: phase 1
• Allocation: NA
• Masking: SINGLE
• Who Masked: INVESTIGATOR
• Purpose: BASIC SCIENCE
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: November 1, 2013
• First Posted: November 8, 2013
• Study Start: August 1, 2010
• Primary Completion: March 1, 2015
• Study Completion: December 1, 2015
• Last Updated: February 5, 2016

Record last verified: 2016-02

Locations

US (1)