Music Therapy to Promote Emotion and Cognition for Dementia
The Effect of Music Therapy on Emotion and Cognition for Individuals With Mild to Moderate Dementia
1 other identifier
interventional
30
1 country
1
Brief Summary
The purpose of this study is to determine if the effects of music therapy alter emotion and cognition performances of individuals with mild to moderate dementia. The music therapy intervention protocol is structured by drum improvisation, rhythm imitation, music cognition and song discussion. Attentive listening and active participation of the music training activities allow participants to utilize their focus of attention and comprehension of informational texts. Music therapy intervention is proposed to provide positive stimulations on emotion and cognitive functions of individuals with dementia. The results of the present study will clarify relationship between the effect of music therapy and the neural substrate of music therapy in anatomical and functional brain data obtained from MRI (fMRI).
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for not_applicable
Started Jun 2013
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
June 1, 2013
CompletedFirst Submitted
Initial submission to the registry
October 6, 2013
CompletedFirst Posted
Study publicly available on registry
October 9, 2013
CompletedPrimary Completion
Last participant's last visit for primary outcome
September 1, 2014
CompletedStudy Completion
Last participant's last visit for all outcomes
September 1, 2014
CompletedOctober 9, 2013
September 1, 2013
1.3 years
October 6, 2013
October 6, 2013
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Brain Changes from Baseline on Functional and Structural Connectivity at 2 Months by Multi-Model MRI Analyses
All participants will received two MRI scans at 0 and 2 months. Images will be acquired on a 3.0T Siemens MRI scanner with 12-channels head coil. All the images are acquired parallel to the anterior commissure-posterior commissure line. To minimize motion artifact generated during the image acquisition, each participant's head will be immobilized with cushions inside the coil. Three kinds of MRI techniques will be performed in this study, including T1-weighted high-resolution anatomical image, resting-state function MRI, and half-sphere diffusion spectrum imaging. Therefore, T1VBM(voxel-based morphology), TBSS(tract-based spatial statistics), functional brain network analysis, and structural brain network analysis will be employed for evaluating the changes of brain functional and structural connectivity in individuals with dementia in experimental and control groups.
Baseline and after 8-week music therapy intervention
Secondary Outcomes (5)
Change from Baseline on Geriatric Depression Scale (GDS) at 2 Months
Baseline and at 2 Months
Change from Baseline on Cohen-Mansfield Agitation Inventory (CMAI) at 2 Months
Baseline and at 2 Months
Change from Baseline on Inventory of Quality of Life (SF-36) at 2 Months
Baseline and at 2 Months
Change from Baseline on Frontal Assessment Battery (FAB) at 2 Months
Baseline and at 2 Months
Change from Baseline on Quality of Drum Improvisation at 2 Months
Baseline and at 2 Months
Study Arms (2)
Music Therapy Group Session
EXPERIMENTALParticipants will receive 60-minute group session twice a week over 2 months of period. Each session will be led by a music therapist. The contents of the music therapy session include drumming, rhythm imitation, score reading, lyrics comprehension, singing, and song discussion.
No Music Therapy Session
NO INTERVENTIONParticipants will receive pre- and post-assessments and evaluations at 0 and 2 months. No intervention will be provided. Music therapy sessions will be offered to participants in completion of their study participation.
Interventions
Eligibility Criteria
You may qualify if:
- a mild dementia diagnosis with Clinical Dementia Rating (CDR) score: 1 and The Mini Mental State Examination (MMSE) score: 18-24
You may not qualify if:
- significant visual and hearing impairment that hinders music listening and score reading
- for fMRI safty: with shrapnel or other metal or electronic implants in their bodies
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Chang Gung Medical Foundation
Taoyuan District, Taiwan, 333, Taiwan
Related Publications (1)
van der Steen JT, van der Wouden JC, Methley AM, Smaling HJA, Vink AC, Bruinsma MS. Music-based therapeutic interventions for people with dementia. Cochrane Database Syst Rev. 2025 Mar 7;3(3):CD003477. doi: 10.1002/14651858.CD003477.pub5.
PMID: 40049590DERIVED
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Yu-Cheng Pei, PhD
Chang Gung Medical Foundation
Central Study Contacts
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- NONE
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
October 6, 2013
First Posted
October 9, 2013
Study Start
June 1, 2013
Primary Completion
September 1, 2014
Study Completion
September 1, 2014
Last Updated
October 9, 2013
Record last verified: 2013-09