NCT01956656

Brief Summary

Due to difficulties in maintenance of an effective mechanical oral hygiene regime, effective chemical adjunctive measures will likely significantly contribute to overall oral health, the function of which should be to augment mechanical plaque control. Traditionally, in Chinese medicine the lotus leaf has been used for treating gingival inflammation. An extract of lotus leaves have demonstrated significant antibacterial activity against some of the periodontopathogens.

Trial Health

43
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
30

participants targeted

Target at below P25 for not_applicable

Timeline
Completed

Started Sep 2013

Shorter than P25 for not_applicable

Geographic Reach
1 country

1 active site

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Start

First participant enrolled

September 1, 2013

Completed
16 days until next milestone

First Submitted

Initial submission to the registry

September 17, 2013

Completed
21 days until next milestone

First Posted

Study publicly available on registry

October 8, 2013

Completed
2 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 1, 2013

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

December 1, 2013

Completed
Last Updated

December 11, 2013

Status Verified

December 1, 2013

Enrollment Period

3 months

First QC Date

September 17, 2013

Last Update Submit

December 10, 2013

Conditions

Keywords

lotus leaf, mouthwash, gingivitis

Outcome Measures

Primary Outcomes (1)

  • Plaque induced gingivitis

    Gingivitis is measured using, Sillness\&Loe(1964):Plaque Index Gingival index(GI)-Loe\&Sillness(1963) before and after dispensing of mouthwash.

    4 days

Secondary Outcomes (1)

  • Grams Staining of the plaque collected from the subjects

    4 days

Study Arms (2)

lotus leaf mouthwash

PLACEBO COMPARATOR

10 ml mouthwash to be used for 4days twice daily

Drug: lotus leaf mouthwash

placebo mouthwash

PLACEBO COMPARATOR

10 ml mouthwash to be used for 4 days twice daily

Interventions

Saline mouthwash to be used for 4 days twice daily by one group the other group the lotus leaf mouthwash

Also known as: Lotus mouthwash
lotus leaf mouthwash

Eligibility Criteria

Age18 Years - 25 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64)

You may qualify if:

  • Subjects willing to comply with the study protocol \& instruction.
  • Clinically diagnosed with chronic gingivitis.
  • No history of allergies to herbal formulations.
  • No history of periodontal therapy within the previous 6 months.
  • No history of antibiotic therapy within the previous 6 months.

You may not qualify if:

  • Any systemic diseases
  • Use of tobacco or tobacco related products
  • Pregnant woman and lactating mothers
  • Subjects that had used any type of antibacterial mouthrinse within 4 weeks of recruitment in to the study.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Sri Hasanamba Dental College and Hospital

Hassan, Karnataka, 573202, India

Location

MeSH Terms

Conditions

Gingivitis

Condition Hierarchy (Ancestors)

InfectionsGingival DiseasesPeriodontal DiseasesMouth DiseasesStomatognathic Diseases

Study Officials

  • Dr Ravindra Shivamurthy, MDS

    Sri Hasanamba Dental College and Hospital

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
DOUBLE
Who Masked
PARTICIPANT, INVESTIGATOR
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
P.G. student

Study Record Dates

First Submitted

September 17, 2013

First Posted

October 8, 2013

Study Start

September 1, 2013

Primary Completion

December 1, 2013

Study Completion

December 1, 2013

Last Updated

December 11, 2013

Record last verified: 2013-12

Locations