NCT01946113

Brief Summary

Acute renal failure is a common complication in intensive care unit patients. In 10% of cases renal replacement therapy becomes necessary. Current devices have increase filter patency and efficacy. However, magnesium, calcium and phosphate are eliminated as well. However, the extend of this elimination hase not been quantified. Thus, we want to

  1. 1.record retrospectively how often abnormal values for phosphate, magnesium and calcium occurred during routine renal replacement therapy in 2011 and 2012.
  2. 2.prospectively evaluate the same parameters during routine treatment in 2013 and 2014

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
200

participants targeted

Target at P75+ for all trials

Timeline
Completed

Started Sep 2013

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

September 1, 2013

Completed
8 days until next milestone

First Submitted

Initial submission to the registry

September 9, 2013

Completed
10 days until next milestone

First Posted

Study publicly available on registry

September 19, 2013

Completed
1.9 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

August 1, 2015

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

August 1, 2015

Completed
Last Updated

August 20, 2015

Status Verified

August 1, 2015

Enrollment Period

1.9 years

First QC Date

September 9, 2013

Last Update Submit

August 19, 2015

Conditions

Acute Renal Failure

Outcome Measures

Primary Outcomes (1)

  • Incidence of hypo-phosphate,-magnesium and calcaemia

    Participants will be followed for the duration of ICU stay, an expected average of 28 days

    approximately 28 days

Study Arms (2)

Retrospektive Cohort

Patients requiring renal replacement therapy from 2011 to 2012 on intensive care unit

Prospektive Cohort

Patients requiring renal replacement on intensive care unit in 2013 and 2014

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

intensive care unit patients with acute renal failure undergoing renal replacement therapy

You may qualify if:

  • intensive care unit patients with acute renal failure undergoing continuous renal replacement therapy
  • older than 18 years of age

You may not qualify if:

  • age less than 18 years
  • pregnancy
  • contraindications against continuous renal replacement therapy

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Interdisziplinäre Intensivstation Universitätsklinikum Düsseldorf

Düsseldorf, 40225, Germany

Location

MeSH Terms

Conditions

Acute Kidney Injury

Condition Hierarchy (Ancestors)

Renal InsufficiencyKidney DiseasesUrologic DiseasesFemale Urogenital DiseasesFemale Urogenital Diseases and Pregnancy ComplicationsUrogenital DiseasesMale Urogenital Diseases

Study Officials

  • Detlef Kindgen-Milles, Prof.

    Department of Anaesthesiology, Duesseldorf University Hospital

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
observational
Observational Model
COHORT
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Prof. Kindgen-Milles

Study Record Dates

First Submitted

September 9, 2013

First Posted

September 19, 2013

Study Start

September 1, 2013

Primary Completion

August 1, 2015

Study Completion

August 1, 2015

Last Updated

August 20, 2015

Record last verified: 2015-08

Locations

DE(1)