Clinical Trial Comparing Continuous Versus Intermittent Hemodialysis in ICU Patients

NCT01228123 | Completed Phase 2

• 1 other identifier: CONVINT
• Study Type: interventional
• Target: 252
• Locations: 1 country
• Sites: 1

Brief Summary

The mortality of acute renal failure (ARF) remains to be high (around 60-70%) despite manifold improvements in ICU care. At present, it is not clear if the method chosen for renal replacement therapy, i.e. intermittent haemodialysis (IHD) or continuous haemofiltration (CVVH), might impact on the outcome of these patients. For this purpose, a prospective randomised clinical study of the effect of continuous versus intermittent renal replacement therapy on the mortality and outcome of acute renal failure will be performed.

Conditions

Acute Renal Failure

Outcome Measures

Primary Outcomes (1)

• Survival at 2 weeks after RRT

  2 weeks after RRT in follow-up

Study Arms (2)

CVVH arm

ACTIVE COMPARATOR

Other: RRT for acute kidney failure using the CVVH method

IHD arm

ACTIVE COMPARATOR

Other: RRT for acute kidney failure using the IHD (intermittent HD)

Interventions

RRT for acute kidney failure using the CVVH method OTHER

patients randomized to receive CVVH

Also known as: does not apply

CVVH arm

RRT for acute kidney failure using the IHD (intermittent HD) OTHER

patients randomized to receive IHD

Also known as: does not apply

IHD arm

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• all ICU patients requiring renal replacement therapy

You may not qualify if:

• patient denies informed consent
• patient not requiring intensive care therapy
• kidney transplanted patients
• chronic renal failure (serum creatinine \> 3mg/dl)

Sponsors & Collaborators

• Charite University, Berlin, Germany: lead

Study Sites (1)

Charite University Medicine

Berlin, State of Berlin, 13353, Germany

Location

Related Publications (2)

• Tsujimoto Y, Miki S, Shimada H, Tsujimoto H, Yasuda H, Kataoka Y, Fujii T. Non-pharmacological interventions for preventing clotting of extracorporeal circuits during continuous renal replacement therapy. Cochrane Database Syst Rev. 2021 Sep 14;9(9):CD013330. doi: 10.1002/14651858.CD013330.pub2.

  PMID: 34519356 DERIVED

• Schefold JC, von Haehling S, Pschowski R, Bender T, Berkmann C, Briegel S, Hasper D, Jorres A. The effect of continuous versus intermittent renal replacement therapy on the outcome of critically ill patients with acute renal failure (CONVINT): a prospective randomized controlled trial. Crit Care. 2014 Jan 10;18(1):R11. doi: 10.1186/cc13188.

  PMID: 24405734 DERIVED

MeSH Terms

Conditions

Acute Kidney Injury

Interventions

Renal Replacement Therapy

Condition Hierarchy (Ancestors)

Renal Insufficiency; Kidney Diseases; Urologic Diseases; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Male Urogenital Diseases

Intervention Hierarchy (Ancestors)

Therapeutics

Study Officials

• Achim Joerres, MD

  Charite University Medicine

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: phase 2
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: DIAGNOSTIC
• Intervention Model: PARALLEL
• Sponsor Type: OTHER

Study Record Dates

• First Submitted: October 25, 2010
• First Posted: October 26, 2010
• Study Start: January 1, 2002
• Primary Completion: October 1, 2007
• Study Completion: January 1, 2008
• Last Updated: May 25, 2011

Record last verified: 2010-07

Locations

DE (1)