Preventing Drug Use in Low Income Clinic Populations

NCT01942876 | Completed Phase 2

• 1 other identifier: DESPR DA022445
• Study Type: interventional
• Target: 411
• Locations: 1 country
• Sites: 1

Brief Summary

The proposed study will address the critical need to reduce illegal drug use, in particular drug use, and the occurrence of drug-related harm in low-income racially diverse patient populations at urban primary care safety-net clinics. Since they are at risk for accelerated trajectories to drug dependence once drug use begins, low-income racially diverse populations pose particular concern for public health policy makers and drug-use prevention efforts. The study will be the first to standardize drug screening and primary-care clinician delivered brief intervention among racially diverse "at risk" drug users, that is users with casual or frequent use without the physiological or psychological manifestations of dependence, to reduce their 'at risk' use of drugs, and it may effectively interrupt their pathway to dependence.

Conditions

Drug Use; Harmful Use

Keywords

Drugs; at risk; community health center patients

Outcome Measures

Primary Outcomes (1)

• Change from Baseline of Self-reported number of drug-free days at 3 month

  past 30 and 90 days

Secondary Outcomes (1)

• Decrease in drug-related harm (e.g., unemployment and job absenteeism, poor social support, poor health-related quality of life, HIV risk behaviors, motor vehicle accidents, and inpatient health services utilization).

  6 and 12 months post randomization

Study Arms (2)

Intervention

EXPERIMENTAL

The Quit Using Drugs Intervention Trial (QUIT) experimental arm includes: screening, very brief clinician advice, and telephone drug-use health education to reduce 'at risk' drug use and thus interrupt progression from casual or episodic abuse to dependence.

Behavioral: Quit Using Drugs Intervention Trial

Control

SHAM COMPARATOR

This arm will receive a sham telephone intervention of equivalent duration on health behavior maintenance.

Behavioral: Health behavior maintenance

Interventions

Quit Using Drugs Intervention Trial BEHAVIORAL

The goal of the Quit Using Drugs Intervention Trial (QUIT) is to conduct a small RCT of a primary care clinic-based very brief intervention protocol for reducing the use of illegal drugs and the occurrences of drug-related harm in low-income, racially-diverse patient populations at two 'safety-net' clinics in Los Angeles. The design will emphasize screening, very brief clinician advice, and telephone drug-use health education to reduce 'at risk' drug use and thus interrupt progression from casual or episodic abuse to dependence.

Also known as: QUIT

Intervention

Health behavior maintenance BEHAVIORAL

This attention-control arm will receive a sham telephone intervention of equivalent duration on health behavior maintenance.

Also known as: Attention-Control condition

Control

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• ages 18 and older
• report of drug use in the previous 90 days (i.e., (marijuana, crack/cocaine, amphetamines/methamphetamines, inhalants, sedatives or sleeping pills, hallucinogens, and opiates)
• an ASSIST score between 4 and 26 indicating 'at risk' drug use
• English or Spanish speaking
• able (not cognitively impaired) and willing to cooperate with data collection and research procedures, including 2 telephone counseling sessions and 3 month follow-up assessments

You may not qualify if:

• Pregnant
• Drug or alcohol dependence

Sponsors & Collaborators

• University of California, Los Angeles: lead

Study Sites (1)

UCLA

Los Angeles, California, 90024, United States

Location

Related Publications (3)

• Gelberg L, Andersen RM, Afifi AA, Leake BD, Arangua L, Vahidi M, Singleton K, Yacenda-Murphy J, Shoptaw S, Fleming MF, Baumeister SE. Project QUIT (Quit Using Drugs Intervention Trial): a randomized controlled trial of a primary care-based multi-component brief intervention to reduce risky drug use. Addiction. 2015 Nov;110(11):1777-90. doi: 10.1111/add.12993.

  PMID: 26471159 RESULT

• Baumeister SE, Gelberg L, Leake BD, Yacenda-Murphy J, Vahidi M, Andersen RM. Effect of a primary care based brief intervention trial among risky drug users on health-related quality of life. Drug Alcohol Depend. 2014 Sep 1;142:254-61. doi: 10.1016/j.drugalcdep.2014.06.034. Epub 2014 Jul 4.

  PMID: 25042213 RESULT

• Bone CW, Goodfellow AM, Vahidi M, Gelberg L. Prevalence of Sexual Violence and its Association with Depression among Male and Female Patients with Risky Drug Use in Urban Federally Qualified Health Centers. J Urban Health. 2018 Feb;95(1):111-115. doi: 10.1007/s11524-017-0213-7.

  PMID: 29340911 DERIVED

Study Officials

• Lillian Gelberg, MD, MSPH

  UCLA Department of Family Medicine

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: phase 2
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: September 6, 2013
• First Posted: September 16, 2013
• Study Start: January 1, 2011
• Primary Completion: February 1, 2013
• Study Completion: February 1, 2013
• Last Updated: November 18, 2016

Record last verified: 2016-11

Locations

US (1)