NCT01372254

Brief Summary

The objective of the proposed project is to develop a novel, behavioral approach to smoking cessation that can be integrated with residential drug use treatment for low income substance using smokers with elevated depressive symptoms. The approach utilizes behavioral activation strategies which have been shown to reduce smoking among community samples and which can be easily targeted for the particular needs of low income substance users.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
96

participants targeted

Target at P75+ for phase_1

Timeline
Completed

Started Dec 2011

Typical duration for phase_1

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

June 10, 2011

Completed
3 days until next milestone

First Posted

Study publicly available on registry

June 13, 2011

Completed
6 months until next milestone

Study Start

First participant enrolled

December 1, 2011

Completed
3.4 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

May 1, 2015

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

May 1, 2015

Completed
5.4 years until next milestone

Results Posted

Study results publicly available

September 14, 2020

Completed
Last Updated

May 18, 2022

Status Verified

May 1, 2022

Enrollment Period

3.4 years

First QC Date

June 10, 2011

Results QC Date

August 24, 2020

Last Update Submit

May 16, 2022

Conditions

Keywords

Cigarette SmokingDrug UseDepressed Mood

Outcome Measures

Primary Outcomes (1)

  • Number of Participants Smoking-Abstinent for 7 Days, 26 Weeks Post Quit Date

    7 days of smoking abstinence confirmed biochemically at 26 weeks

    26 weeks post quit date

Study Arms (2)

Standard smoking cessation

ACTIVE COMPARATOR

Participants will receive a standard smoking cessation treatment in individual format. Treatment will be delivered in five, 90-minute individual sessions, and with two booster sessions assessed scheduled 2 and 4 weeks post quit. Participants will also receive 8 weeks of the transdermal nicotine patch.

Behavioral: Standard TreatmentDrug: Transdermal Nicotine Patch

BA for substance abusing smokers

EXPERIMENTAL

The Behavioral Activation for Drug Abusing Smokers (BA-DAS) treatment protocol will incorporate elements of the ST along with behavioral activation strategies, modified for smoking. Treatment will consist of five, 90-minute individual sessions, and with two booster sessions scheduled 2 and 4 weeks post quit. Participants will also receive 8 weeks of the transdermal nicotine patch.

Behavioral: BAD-ASDrug: Transdermal Nicotine Patch

Interventions

Participants will receive a standard smoking cessation treatment in individual format. Treatment will be delivered in five, 90-minute individual sessions, and with two booster sessions assessed scheduled 2 and 4 weeks post quit. Participants will also receive 8 weeks of the transdermal nicotine patch.

Also known as: ST
Standard smoking cessation
BAD-ASBEHAVIORAL

The Behavioral Activation for Drug Abusing Smokers (BA-DAS) treatment protocol will incorporate elements of the ST along with behavioral activation strategies, modified for smoking. Treatment will consist of five, 90-minute individual sessions, and with two booster sessions scheduled 2 and 4 weeks post quit. Participants will also receive 8 weeks of the transdermal nicotine patch.

BA for substance abusing smokers

8 weeks of the Transdermal Nicotine Patch Nicoderm CQ at 24 hour doses of 21, 14, and 7 mg respectively depending on participant's initial level of nicotine use. Nicotine patch dose will decrease at 2 or 4 week increments also specific to the participant's initial nicotine level. Participants in both intervention arms will receive transdermal nicotine patch.

Also known as: Nicoderm CQ
BA for substance abusing smokersStandard smoking cessation

Eligibility Criteria

Age18 Years - 65 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • between 18 and 65 years of age
  • regular smoker for at least one year
  • currently smoking an average ≥ 10 cigarettes (also cigarellos, bidis, or Black and Milds included) per day
  • report motivation to quit smoking in the next month
  • report elevated depressive symptoms

You may not qualify if:

  • physical concerns contraindicating the nicotine patch
  • limited mental competency and/or the inability to give informed, voluntary, written consent to participate
  • current use of pharmacotherapy for smoking cessation not provided by the researchers during the quit attempt
  • use of psychotropic medication for \< 3 months
  • primary use of other tobacco products (specifically: chewing tobacco, cigars, and pipes)
  • psychotic symptoms
  • current pregnancy or plans to become pregnant within the following three months

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Salvation Army Harbor Light Center

Washington D.C., District of Columbia, 20002, United States

Location

MeSH Terms

Conditions

Cigarette SmokingConsciousness Disorders

Interventions

Tobacco Use Cessation DevicesNicotine

Condition Hierarchy (Ancestors)

Tobacco SmokingSmokingBehaviorTobacco UseNeurobehavioral ManifestationsNeurologic ManifestationsNervous System DiseasesSigns and SymptomsPathological Conditions, Signs and SymptomsNeurocognitive DisordersMental Disorders

Intervention Hierarchy (Ancestors)

TherapeuticsSolanaceous AlkaloidsAlkaloidsHeterocyclic CompoundsPyridinesHeterocyclic Compounds, 1-Ring

Results Point of Contact

Title
Laura MacPherson
Organization
University of Maryland

Study Officials

  • Laura MacPherson, PhD

    University of Maryland

    PRINCIPAL INVESTIGATOR

Publication Agreements

PI is Sponsor Employee
No
Restrictive Agreement
No

Study Design

Study Type
interventional
Phase
phase 1
Allocation
RANDOMIZED
Masking
SINGLE
Who Masked
PARTICIPANT
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Dr. Laura MacPherson

Study Record Dates

First Submitted

June 10, 2011

First Posted

June 13, 2011

Study Start

December 1, 2011

Primary Completion

May 1, 2015

Study Completion

May 1, 2015

Last Updated

May 18, 2022

Results First Posted

September 14, 2020

Record last verified: 2022-05

Locations