Aerobic Exercise During Hemodialysis

NCT01912417 | Unknown

• 1 other identifier: 01
• Study Type: interventional
• Target: 28
• Locations: 1 country
• Sites: 1

Brief Summary

The aim of this study is to evaluate the effect of aerobic exercise during dialysis on the hemodialysis efficacy in the removal of small molecules measured by continues spend sampling of dialysate (liquid metabolites produced by the body which is disposed) technique.

Conditions

Kidney Failure, Chronic

Keywords

HEMODIALYSIS; Kidney Failure, Chronic; AEROBIC EXERCISE

Outcome Measures

Primary Outcomes (1)

• The main outcome was the dialysate concentrations of urea, creatinine, potassium and phosphate.

  The dialysate is collected by continuous spent sampling of dialysate (CSSD). For the CSSD technique, spent dialysate was continuously sampled by a reversed automatic infusion pump (Lifemed®) at a rate of 10 mL/hour. The dialysate concentrations of urea, creatinine, potassium and phosphate are measured in the sample recipient and the total masses removed are calculated by multiplying the dialysate concentration by the estimated total dialysate volume.

  three months

Study Arms (2)

Hemodialysis session with exercise

EXPERIMENTAL

Patients were included in a randomly crossover study design such that each patient received one HD session with exercise (intervention) and the next session without exercise (control), alternating for six consecutive HD sessions.

Other: Aerobic exercise with cycle ergometer during hemodialysis

hemodialysis session without exercise

NO INTERVENTION

Each patient received one hemodialysis session without exercise

Interventions

Aerobic exercise with cycle ergometer during hemodialysis OTHER

Participants underwent hemodialysis trained on an cycle ergometer. The training is performed in the first 2 hours of hemodialysis, with a total exercise time of 60 minutes. Each exercise period of 20 minutes was separated by 10 minutes of rest. The patients are advised to work with a level of perceived exertion of 'somewhat strong' (13-14 of Borg scale). For safety, heart rate and blood pressure were monitored throughout the session. The training is terminated if the patients exceeded 80% of their maximum heart rate (MHR = 220 - age in years), blood pressure parameters are exceeded (above 200/110 or below 110/50mmHg) or the patient had chest pain, severe dyspnea, wheezing, leg cramps, confusion, visual symptoms, pallor or cyanosis.

Hemodialysis session with exercise

Eligibility Criteria

• Age: 15 Years - 90 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)

Sponsors & Collaborators

• Universidade Católica de Pelotas: lead

Study Sites (1)

Hospital São Francisco de Paula

Pelotas, Rio Grande do Sul, 96020-220, Brazil

Location

MeSH Terms

Conditions

Kidney Failure, Chronic

Interventions

Exercise

Condition Hierarchy (Ancestors)

Renal Insufficiency, Chronic; Renal Insufficiency; Kidney Diseases; Urologic Diseases; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Male Urogenital Diseases; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Msc

Study Record Dates

• First Submitted: July 26, 2013
• First Posted: July 31, 2013
• Study Start: August 1, 2010
• Primary Completion: February 1, 2012
• Study Completion: January 1, 2014
• Last Updated: September 5, 2013

Record last verified: 2013-09

Locations

BR (1)