Effect of Exercise on Endothelial Function and Vascular Compliance in Chronic Kidney Disease

NCT01068314 | Completed

• 1 other identifier: UI200308021
• Study Type: interventional
• Target: 12
• Locations: 1 country
• Sites: 1

Brief Summary

The study hypothesis is that 6 weeks of repetitive handgrip exercise will improve endothelial function and venous compliance in pre-dialysis patients with an estimated glomerular filtration rate of less than or equal to 20 ml/min. If proven correct then arm exercise might be useful to improve the success rate for a surgically created arteriovenous fistula in the forearm to become usable as a vascular access for hemodialysis.

Conditions

Kidney Failure, Chronic

Keywords

Endothelium; Vasodilatation; Vein; Compliance; Arteriovenous shunt, surgical

Outcome Measures

Primary Outcomes (1)

• Brachial artery flow-mediated dilatation

  6 weeks

Secondary Outcomes (1)

• Forearm venous compliance by plethysmography

  6 weeks

Study Arms (2)

Repetitive handgrip exercise

EXPERIMENTAL

After baseline testing and randomization, subjects in this group are instructed to perform the intervention: daily repetitive handgrip exercise with upper arm compression band. Brachial artery endothelial function and venous compliance are tested at baseline and 6 weeks.

Other: Repetitive arm exercise

No arm exercise

NO INTERVENTION

Time control. Subjects do usual activities without any exercise intervention. Brachial artery endothelial function and venous compliance are tested at baseline and 6 weeks.

Interventions

Repetitive arm exercise OTHER

After baseline testing and randomization, subjects in this group are instructed to perform repetitive handgrip exercise with an upper arm compression band until arm fatigue occurs. After resting 1 minute this exercise is repeated 9 times daily for 6 weeks.

Repetitive handgrip exercise

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Age exceeding the age of majority (18 years of age).
• Chronic renal failure with a calculated GFR (MDRD equation) less than or equal to 20 ml/min
• Eligible for creation of an arteriovenous fistula for the purpose of hemodialysis.
• The subject is expected to stay within driving distance of study site for at least 4 months.
• The subject's physician(s) will allow the patient to participate.
• Ability to give informed consent.

You may not qualify if:

• Unstable angina.
• Uncontrolled hypertension (resting blood pressure \>170 systolic or \>100 diastolic).
• Musculoskeletal or neurologic problem that prevents arm exercise.
• Currently functioning arteriovenous access in the same arm as the planned new fistula.
• Subjects who are eligible to participate in the ongoing DAC fistula trial.
• Planned new access surgery in less than 6 weeks
• Anticipated non-compliance with medical care based on physician judgment.
• Patient refusal.

Sponsors & Collaborators

• University of Iowa: lead

Study Sites (1)

University of Iowa General Clinical Research Center

Iowa City, Iowa, 52242, United States

Location

Related Publications (1)

• Nantakool S, Reanpang T, Prasannarong M, Pongtam S, Rerkasem K. Upper limb exercise for arteriovenous fistula maturation in people requiring permanent haemodialysis access. Cochrane Database Syst Rev. 2022 Oct 3;10(10):CD013327. doi: 10.1002/14651858.CD013327.pub2.

  PMID: 36184076 DERIVED

MeSH Terms

Conditions

Kidney Failure, Chronic; Aneurysm; Patient Compliance; Arteriovenous Fistula

Condition Hierarchy (Ancestors)

Renal Insufficiency, Chronic; Renal Insufficiency; Kidney Diseases; Urologic Diseases; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Male Urogenital Diseases; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Vascular Diseases; Cardiovascular Diseases; Patient Acceptance of Health Care; Treatment Adherence and Compliance; Health Behavior; Behavior; Arteriovenous Malformations; Vascular Malformations; Cardiovascular Abnormalities; Vascular Fistula; Congenital Abnormalities; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Fistula; Pathological Conditions, Anatomical

Study Officials

• Bradley S Dixon, MD

  University of Iowa

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor of Medicine

Study Record Dates

• First Submitted: February 11, 2010
• First Posted: February 12, 2010
• Study Start: January 1, 2007
• Primary Completion: May 1, 2008
• Study Completion: June 1, 2010
• Last Updated: February 27, 2014

Record last verified: 2014-02

Locations

US (1)