Cardiovascular and Renal Microvascular Outcome Study With Linagliptin in Patients With Type 2 Diabetes Mellitus (CARMELINA)
CARMELINA: A Multicenter, International, Randomized, Parallel Group, Double-blind, Placebo-controlled, Cardiovascular Safety and Renal Microvascular Outcome Study With Linagliptin, 5 mg Once Daily in Patients With Type 2 Diabetes Mellitus at High Vascular Risk
2 other identifiers
interventional
6,991
27 countries
649
Brief Summary
The aim of the study is to investigate the longterm impact on cardiovascular morbidity, mortality and renal function of treatment with linagliptin in a selected population of patients with Type 2 diabetes mellitus (T2DM) and to compare outcomes against placebo, on a background of standard of care.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for phase_4 diabetes-mellitus-type-2
Started Jul 2013
Longer than P75 for phase_4 diabetes-mellitus-type-2
649 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
July 9, 2013
CompletedStudy Start
First participant enrolled
July 10, 2013
CompletedFirst Posted
Study publicly available on registry
July 12, 2013
CompletedPrimary Completion
Last participant's last visit for primary outcome
January 18, 2018
CompletedStudy Completion
Last participant's last visit for all outcomes
January 18, 2018
CompletedResults Posted
Study results publicly available
January 25, 2019
CompletedApril 4, 2019
March 1, 2019
4.5 years
July 9, 2013
December 21, 2018
March 21, 2019
Conditions
Outcome Measures
Primary Outcomes (1)
Time to the First Occurrence of Any of the Following Adjudication-confirmed Components of the Primary Composite Endpoint 3-point Major Adverse Cardiovascular (CV) Events (3-point MACE): CV Death, Non-fatal Myocardial Infarction (MI) or Non-fatal Stroke.
Time to event analysis of patients with first occurrence of any of the following adjudication-confirmed components of the primary composite endpoint (3-point MACE): CV death, non-fatal MI or non-fatal stroke. The percentage of observed patients with first occurrence of any of the following adjudication-confirmed components of the primary composite endpoint (3-point MACE) was reported.
From randomization to individual end of observation; up to 4.3 years
Secondary Outcomes (1)
Time to the First Occurrence of Any of the Following Adjudication-confirmed Components: Renal Death, Sustained End Stage Renal Disease (ESRD), or Sustained Decrease of 40% or More in Estimated Glomerular Filtration Rate (eGFR).
From randomization to individual end of observation; up to 4.3 years
Study Arms (2)
Linagliptin
EXPERIMENTALPlacebo
PLACEBO COMPARATORInterventions
Eligibility Criteria
You may qualify if:
- Documented diagnosis of T2DM before visit 1(screening).
- Male or female patients who are drug-naïve or pre-treated with any antidiabetic background medication, excluding treatment with Glucagon-like Peptide 1 (GLP-1) receptor agonists, Dipeptidyl-peptidase 4 (DPP-4) inhibitors or Sodium Glucose Linked Transporter 2 (SGLT-2) inhibitors if =\> consecutive 7 days.
- Stable antidiabetic background medication (unchanged daily dose) for at least 8 weeks prior to randomization. If insulin is part of the background therapy, the average daily insulin dose should not have changed by more than 10% within the 8 weeks prior to randomization compared with the daily insulin dose at randomization.
- HbA1c of =\> 6.5% and \<= 10.0% at Visit 1 (screening)
- Age =\> 18 years at Visit 1(screening). For Japan only: Age =\> 20 years at Visit 1
- Body Mass Index (BMI) \<= 45 kg/m2 at Visit 1 (screening)
- Signed and dated written informed consent by date of Visit 1(screening) in accordance with Good Clinical Practice (GCP) and local legislation prior to any study related procedure
- High risk of cardiovascular (CV) events defined by: 1) albuminuria (micro or macro) and previous macrovascular disease and/or 2) impaired renal function with predefined Urine Albumin Creatinine Ratio (UACR)
You may not qualify if:
- Type 1 diabetes mellitus.
- Treatment (=\> 7 consecutive days) with GLP-1 receptor agonists, other DPP-4 inhibitors or SGLT-2 inhibitors prior to informed consent. Note: This also includes clinical trials where these antidiabetic drugs have been provided to the patient.
- Active liver disease or impaired hepatic function, defined by serum levels of either Alanine Transaminase (ALT) (SGPT), Aspartate transaminase (AST) (SGOT), or alkaline phosphatase (AP) =\> 3 x upper limit of normal (ULN) as determined at Visit 1.
- Estimated Glomerular filtration Rate (eGFR) \<15 ml/min/1.73 m2 (severe renal impairment or End Stage Renal Disease (ESRD), Modification of Diet in Renal Disease (MDRD) formula), as determined during screening at Visit 1 and/or the need for maintenance dialysis.
- Any previous (or planned within next 12 months) bariatric surgery (open or laparoscopic) or intervention (gastric sleeve).
- Pre-planned coronary artery re-vascularisation (PCI, CABG) or any previous PCI and/or CABG \<= 2 months prior informed consent.
- Known hypersensitivity or allergy to the investigational products or its excipients.
- Any previous or current alcohol or drug abuse that would interfere with trial participation in the opinion of the investigator.
- Participation in another trial with an investigational drug ongoing or within 2 months prior to visit 1 (screening).
- Pre-menopausal women (last menstruation = 1 year prior to informed consent) who are nursing or pregnant, are of child-bearing potential and are not practicing an acceptable method of birth control (acceptable methods of birth control include tubal ligation, transdermal patch, intra uterine devices/systems (IUDs/IUSs), oral, implantable or injectable contraceptives, sexual abstinence (if allowed by local authorities), double barrier method and vasectomised partner) or do not plan to continue using acceptable method of birth control throughout the study and do not agree to submit to periodic pregnancy testing during participation in the trial.
- Patients considered unreliable by the investigator concerning the requirements for follow up during the study and/or compliance with study drug administration, have a life expectancy less than 5 years for non-CV causes, or have cancer other than non-melanoma skin cancer within last 3 years, or has any other condition than mentioned which in the opinion of the investigator, would not allow safe participation in the study.
- Acute coronary syndrome (ACS), diagnosed \<= 2 months prior to visit 1 (screening).
- Stroke or Transient Ischemic Attack (TIA) \<= 3 months prior to visit 1 (screening).
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Boehringer Ingelheimlead
- Eli Lilly and Companycollaborator
Study Sites (649)
Longwood Research
Huntsville, Alabama, 35801, United States
Scottsboro Quick Care Clinic
Scottsboro, Alabama, 35768, United States
Office of Dr. Terence T. Hart MD
Tuscumbia, Alabama, 35674, United States
Arrowhead Health Centers
Glendale, Arizona, 85306, United States
Precision Trials, LLC
Phoenix, Arizona, 85032, United States
Harrisburg Family Medical Center
Harrisburg, Arkansas, 72432, United States
Cardiology and Medicine Clinic
Little Rock, Arkansas, 72204, United States
Little Rock Diagnostic Clinic
Little Rock, Arkansas, 72205, United States
Kaiser Permanente - San Diego, Bonita
Bonita, California, 91902, United States
John Muir Physician Network Clinical Research Center
Concord, California, 94520, United States
Valley Research
Fresno, California, 93720, United States
VA Loma Linda Healthcare System
Loma Linda, California, 92357, United States
Long Beach Center for Clinical Research
Long Beach, California, 90807, United States
Clearview Medical Research, LLC
Los Angeles, California, 90019, United States
National Research Institute
Los Angeles, California, 90057, United States
Office of Dr. Richard S. Cherlin
Los Gatos, California, 95032, United States
Coastal Medical Research Group
Los Osos, California, 93402, United States
Novo Research, Incorporated
Modesto, California, 95350, United States
Providence Clinical Research
North Hollywood, California, 91606, United States
Northridge Clinical Research Inc.
Northridge, California, 91324, United States
Carr Cardiology
Oceanside, California, 92056, United States
Center for Clinical Trials of Sacramento, Incorporated
Sacramento, California, 95823, United States
North America Research Institute
San Dimas, California, 91773, United States
Trinitas Research, Incorporated
San Jose, California, 95116, United States
Metabolic Institute of America
Tarzana, California, 91356, United States
Center for Clinical Trials of San Gabriel
West Covina, California, 91790, United States
Western Nephrology & Metabolic
Arvada, Colorado, 80002, United States
South Denver Nephrology
Denver, Colorado, 80210, United States
Colorado Center for Bone Research, P.C.
Golden, Colorado, 80401, United States
Helix Biomedics LLC
Boynton Beach, Florida, 33435, United States
Orthopedic Research Institute
Boynton Beach, Florida, 33437, United States
Nova Clinical Research, LLC
Bradenton, Florida, 34209, United States
PAB Clinical Research
Brandon, Florida, 33511, United States
Meridien Research
Brooksville, Florida, 34601, United States
Southeast Clinical Research, LLC
Chiefland, Florida, 32626, United States
BayCare Medical Group
Clearwater, Florida, 33756, United States
Cohen Medical Research Associates, LLC
Delray Beach, Florida, 33446, United States
Innovation Medical Research Center, Inc
Doral, Florida, 33166, United States
Integrative Research Associates
Fort Lauderdale, Florida, 33312, United States
Jellinger and Lerman, MD, PA dba The Center for Diabetes and Endocrine Care
Fort Lauderdale, Florida, 33312, United States
Direct Helpers Medical Center, Inc
Hialeah, Florida, 33012, United States
Universal Clinical Research
Hialeah, Florida, 33012, United States
Homestead Associates in Research
Homestead, Florida, 33032, United States
St. Vincent's Cardiology
Jacksonville, Florida, 32216, United States
Care Partners Clinical Research LLC
Jacksonville, Florida, 32277, United States
Altus Research, Inc.
Lake Clarke Shores, Florida, 33406, United States
Meridien Research
Lakeland, Florida, 33805, United States
Clinical Research of Miami
Miami, Florida, 33126, United States
Prestige Clinical Research Center, Inc.
Miami, Florida, 33133, United States
Jesscan Medical Research, Internal Medicine
Miami, Florida, 33134, United States
Clintex Research Group, Inc. Research
Miami, Florida, 33135, United States
University of Miami
Miami, Florida, 33136, United States
Florida Medical Center & Research Inc
Miami, Florida, 33142, United States
A+ Research Incorporated
Miami, Florida, 33144, United States
Unlimited Medical Research, LLC
Miami, Florida, 33144, United States
Regenerate Clinical Trials
Miami, Florida, 33155, United States
Sanitas Research
Miami, Florida, 33155, United States
Future Care Solution, LLC
Miami, Florida, 33165, United States
Research Institute of South Florida Inc
Miami, Florida, 33173, United States
Tellus Clinical Research, Incorporated
Miami, Florida, 33173, United States
New Horizon Research Center
Miami, Florida, 33175, United States
Kendall South Medical Center, Inc
Miami, Florida, 33185, United States
Coral Research Clinic Corp
Miami, Florida, 33186, United States
Precision Research Organization
Miami Lakes, Florida, 33016, United States
School of Clinical Research
North Miami Beach, Florida, 33144, United States
Harmony Clinical Research, Incorporated
North Miami Beach, Florida, 33162, United States
Magnolia Research Group
Ocala, Florida, 34471, United States
Family Medical Center
Orlando, Florida, 32806, United States
Peninsula Research, Inc.
Ormond Beach, Florida, 32174, United States
Infinity Clinical Research, LLC
Plantation, Florida, 33317, United States
Intercoastal Medical Group, Endocrinology
Sarasota, Florida, 34232, United States
Meridien Research
St. Petersburg, Florida, 33709, United States
Professional Health Care of Pinellas, Inc.
St. Petersburg, Florida, 33713, United States
Meridien Research
Tampa, Florida, 33634, United States
Metabolic Research Institute
West Palm Beach, Florida, 33401, United States
Emory University
Atlanta, Georgia, 30303, United States
Laureate Clinical Research Group, LLC
Atlanta, Georgia, 30308, United States
Bainbridge Medical Associates
Bainbridge, Georgia, 39819, United States
Atlanta Heart Specialists, LLC
Cumming, Georgia, 30041, United States
McGarity, Jr., William C.
Decatur, Georgia, 30035-4000, United States
Atlanta Heart Specialists, LLC
Tucker, Georgia, 30084, United States
Belleville Family Medical Associates, Ltd
Belleville, Illinois, 62220, United States
Cedar-Crosse Research Center
Chicago, Illinois, 60607, United States
Chicago Clinical Research Institute, Inc.
Chicago, Illinois, 60607, United States
Associates in Endocrinology, Incorporated
Elgin, Illinois, 60124, United States
Kidney Care Center, Nephrology
Joliet, Illinois, 60435, United States
American Health Network
Avon, Indiana, 46123, United States
American Health Network of Indiana, LLC
Franklin, Indiana, 46131, United States
American Health Network of Indiana, LLC
Greenfield, Indiana, 46140, United States
American Health Network of Indiana, LLC
Muncie, Indiana, 47304, United States
Buynak Clinical Research
Valparaiso, Indiana, 46383, United States
Northeast Iowa Medical Education Foundation
Waterloo, Iowa, 50702, United States
Iowa Diabetes and Endocrinology Research Center
West Des Moines, Iowa, 50265, United States
Cotton-O'Neil Clinical Research Center
Topeka, Kansas, 66606, United States
Professional Research Network of Kansas, LLC
Wichita, Kansas, 67203, United States
Heartland Research Associates, LLC
Wichita, Kansas, 67205, United States
The Research Group of Lexington, LLC
Lexington, Kentucky, 40503, United States
Diabetes and Metabolism Associates APMC
Metairie, Louisiana, 70006, United States
Tulane University Hospital and Clinic
New Orleans, Louisiana, 70112, United States
Maryland Cardiovascular Specialists
Baltimore, Maryland, 21229, United States
Overlea Personal Physicians
Baltimore, Maryland, 21236, United States
Johns Hopkins University
Baltimore, Maryland, 21287, United States
Delmarva Heart Research Foundation, Inc
Salisbury, Maryland, 21804, United States
Endeavor Medical Research
Alpena, Michigan, 49707, United States
University of Michigan Health System
Ann Arbor, Michigan, 48105, United States
Aa Mrc Llc
Flint, Michigan, 48504, United States
McLaren Northern Michigan Hospital
Petoskey, Michigan, 49770, United States
Remedica LLC
Rochester, Michigan, 48307, United States
Tri-County Research, Inc
Sterling Heights, Michigan, 48310-3503, United States
Oakland Medical Research Center
Troy, Michigan, 48085, United States
HealthEast St. Joseph's Hospital
Saint Paul, Minnesota, 55102, United States
Mississippi Medical Research, LLC
Carriere, Mississippi, 39426, United States
Truman Medical Centers, Inc.
Kansas City, Missouri, 64108, United States
Kansas City Veterans Administration Medical Center
Kansas City, Missouri, 64128, United States
Glacier View Cardiology, PC
Kalispell, Montana, 59901, United States
Platte River Nephrology
North Platte, Nebraska, 69101, United States
Omaha Veterans Affairs Medical Center
Omaha, Nebraska, 68131, United States
Alas Science Clinical Research
Las Vegas, Nevada, 89120, United States
USMA Clin. Research/Union Square Med. Associates
Elizabeth, New Jersey, 07201, United States
Mount Sinai - PRIME
Linden, New Jersey, 07036, United States
New Mexico Clinical Research and Osteoporosis Center, Inc.
Albuquerque, New Mexico, 87106, United States
Life Medi-Research and Management
Brooklyn, New York, 11206, United States
United Medical Associates
Johnson City, New York, 13901, United States
Saratoga Clinical Research, LLC
Saratoga Springs, New York, 12866, United States
Jacobi Medical Center
The Bronx, New York, 10461, United States
Kernodle Clinic West
Burlington, North Carolina, 27215, United States
Main Street Physicians Care
Calabash, North Carolina, 28467, United States
Box Arthritis & Rheumatology of the Carolinas
Charlotte, North Carolina, 28210, United States
Clinical Research of Gastonia
Gastonia, North Carolina, 28054, United States
Medication Management, LLC
Greensboro, North Carolina, 27408, United States
PMG Research of Bristol, LLC
Hickory, North Carolina, 28601, United States
Novant Health Southern Piedmont Primary Care
Monroe, North Carolina, 28110, United States
Research Institute of the Carolinas, PLC
Mooresville, North Carolina, 28117, United States
Down East Medical Associates
Morehead City, North Carolina, 28557, United States
Burke Primary Care
Morganton, North Carolina, 28655, United States
PMG Research of Salisbury, LLC
Salisbury, North Carolina, 28144, United States
Natalie A Doyle, M.D., P.A.
Wilson, North Carolina, 27893, United States
Summa Health System
Akron, Ohio, 44304, United States
Medical Frontiers, LLC
Carlisle, Ohio, 45005, United States
Dayton VA Medical Center
Dayton, Ohio, 45428, United States
Norton Community Care
Norton, Ohio, 44203, United States
Apex Medical Research, AMR, Incorporated
Springfield, Ohio, 45505, United States
ProMedica Health Education & Research Corp.
Toledo, Ohio, 43606, United States
COR Clinical Research, LLC
Oklahoma City, Oklahoma, 73103, United States
Lynn Health Science Institute
Oklahoma City, Oklahoma, 73112, United States
The Corvallis Clinic, PC
Corvallis, Oregon, 97330, United States
Blair Medical Associates
Altoona, Pennsylvania, 16602, United States
Clinical Research Associates of Central Pennsylvania
Altoona, Pennsylvania, 16602, United States
Central Bucks Cardiology
Doylestown, Pennsylvania, 18901, United States
Doylestown Health Cardiology
Doylestown, Pennsylvania, 18901, United States
Lycoming Internal Medicine, Inc
Jersey Shore, Pennsylvania, 17740, United States
Montgomery Medical Incorporated
Smithfield, Pennsylvania, 15478, United States
Clinical Trials of South Carolina
Charleston, South Carolina, 29406, United States
Medical University of South Carolina
Charleston, South Carolina, 29425, United States
Spectrum Medical Research, LLC
Gaffney, South Carolina, 29341, United States
VitaLink Research
Greenville, South Carolina, 29615, United States
Mountain View Clinical Research
Greer, South Carolina, 29651, United States
Vita Link Research- Rock Hill
Rock Hill, South Carolina, 29732, United States
Health Concepts
Rapid City, South Dakota, 57702, United States
Holston Medical Group
Bristol, Tennessee, 37620, United States
State of Franklin Healthcare Associates, PLLC
Johnson City, Tennessee, 37604, United States
DCT- AACT, LLC dba Discovery Clinical Trials
Austin, Texas, 78758, United States
Rockwood Medical Clinic
Bedford, Texas, 76022, United States
Texas Health Physicians Group
Dallas, Texas, 75218, United States
Research Institute of Dallas
Dallas, Texas, 75231, United States
Ben Taub General Hospital
Houston, Texas, 77030, United States
Southwest Clinical Trials
Houston, Texas, 77074, United States
The Endocrine Center
Houston, Texas, 77079, United States
Texas Family Geriatrics Clinic
Houston, Texas, 77082, United States
Memorial Clinical Associates Research
Houston, Texas, 77084, United States
Break Through Medical Research
Irving, Texas, 75039, United States
Medical & Surgical Clinic
Irving, Texas, 75061, United States
West Memorial Family Practice
Katy, Texas, 77450, United States
Hill Country Medical Associates
New Braunfels, Texas, 78130, United States
Permian Research Foundation
Odessa, Texas, 79761, United States
Methodist Hospital Research Institute, Internal Medicine
Pearland, Texas, 77584, United States
Health Texas Research Institute
San Antonio, Texas, 78228-6205, United States
Covenant Clinical Research, PA
San Antonio, Texas, 78229, United States
DM Clinical Research
San Antonio, Texas, 78249, United States
DCT-Stone Oak, LLC dba Discovery Clinical Trials
San Antonio, Texas, 78258, United States
Sealy Urgent Care Center and Medical Clinic
Sealy, Texas, 77474, United States
Pioneer Research Solutions, Inc.
Sugar Land, Texas, 77479, United States
DM Clinical Research
Tomball, Texas, 77375, United States
Crossroads Clinical Research, LLC
Victoria, Texas, 77901, United States
Ericksen Research & Development, LLC
Clinton, Utah, 84015, United States
Focus Clinical Research
Draper, Utah, 84020, United States
Advanced Research Institute
Ogden, Utah, 84405, United States
Paramount Medical Care
Ogden, Utah, 84405, United States
Burke Internal Medicine and Research
Burke, Virginia, 22015, United States
Nova Health Management & Research Group, PC
Herndon, Virginia, 20170, United States
Manassas Clinical Research Center
Manassas, Virginia, 20110, United States
Dominion Medical Associates, Inc.
Richmond, Virginia, 23219, United States
Hunter Holmes McGuire Veterans Administration Medical Center
Richmond, Virginia, 23249, United States
Roanoke Heart Institute PLC
Roanoke, Virginia, 24014, United States
Salem Veterans Affairs Medical Center
Salem, Virginia, 24153, United States
Sound Medical Research
Port Orchard, Washington, 98366, United States
Zablocki VA Medical Center
Milwaukee, Wisconsin, 53295, United States
Instituto Médico Adrogué
Adrogué, B1846DSK, Argentina
Hospital Interzonal General de Agudos Dr Jose Penna
Bahía Blanca, 8000, Argentina
Inst de Inv Clinicas-Bahia Blanca
Bahía Blanca, B8000FTD, Argentina
Hospital Italiano Regional del Sur, Bahia Blanca
Bahía Blanca, B8001HXM, Argentina
Hospital Sirio-Libanés
Caba, C1419GEP, Argentina
Centro de Investigaciones Metabólicas
Ciudad Autonoma Buenos Aires, C1056ABJ, Argentina
CIPREC
Ciudad Autonoma Buenos Aires, C1119ACN, Argentina
Hospital Italiano
Ciudad Autonoma Buenos Aires, C1181ACH, Argentina
Consultorios Asociados de Endocrinología e Invest Clínica
Ciudad Autonoma Buenos Aires, C1425AGC, Argentina
CEDIC - Centro de Investigacion Clinica
Ciudad Autonoma Buenos Aires, C1425DES, Argentina
Instituto Cardiovascular de Buenos Aires
Ciudad Autonoma Buenos Aires, C1428ART, Argentina
CCBR - Buenos Aires - AR
Ciudad Autonoma Buenos Aires, C1430CKE, Argentina
Centro Médico Viamonte
Ciudad Autonoma de Bs As, C1120AAC, Argentina
Centro Universitario de Investigacion Corrientes
Corrientes, W3400, Argentina
Centro Médico Colon
Córdoba, 5000, Argentina
CEMAIC - Centro Medico Especializado
Córdoba, 5008, Argentina
Inst. Privado de Inv. Clínicas de Córdoba
Córdoba, X5000AAW, Argentina
Sanatorio Allende S.A.
Córdoba, X5000JHQ, Argentina
Clínica Colombo
Córdoba, X5002AOQ, Argentina
Instituto DAMIC - Fundacion Rusculleda
Córdoba, X5003DCE, Argentina
Hospital Cordoba
Córdoba, X5004CDT, Argentina
IPAC - Clínica Privada Caraffa SRL
Córdoba, X5008KKF, Argentina
Clinica Privada del Prado
Córdoba, X5020AAA, Argentina
CIPADI
Godoy Cruz, 5501, Argentina
Centro Medico Dr. Javier Marino
Haedo, B1706CZA, Argentina
Hospital Italiano de La Plata
La Plata, B1900AXI, Argentina
Unidad de Cardiologia Clinica
Mar del Plata, B7600FEN, Argentina
Hospital Privado de Comunidad
Mar del Plata, B7602CBM, Argentina
Hospital Central de Mendoza, Mendoza
Mendoza, 5500, Argentina
Hospital San Martin
Paraná, E3100BBJ, Argentina
Sanatorio San Martin S.A., Venado Tuerto
Pellegrini, S2600KUE, Argentina
CER Instituto Médico
Quilmes, B1878DVB, Argentina
Instituto de Investigaciones Clínicas de Quilmes
Quilmes, B1878GEG, Argentina
Instituto de Investigaciones Clinicas de Rosario
Rosario, 2000, Argentina
Instituto Medico de la Fundacion Estudios Clinicos, Rosario
Rosario, 2000, Argentina
Instituto Medico Fundación Grupo Colaborativo Rosario
Rosario, 2000, Argentina
Sanatorio Británico
Rosario, 2000, Argentina
Sanatorio Norte
Rosario, 2000, Argentina
Instituto de Hematologia y Medicina Clinica Ruben Davoli
Rosario, CP2000, Argentina
Sanatorio Delta
Rosario, S2000BIF, Argentina
Centro Medico CIR
Rosario, S2000DEJ, Argentina
CEDyN
Rosario, S2000DNM, Argentina
Instituto CAICI
Rosario, S2000PBJ, Argentina
Instituto Medico CENICLAR-C de Investigaciones Clinicas
Rosario, S2000QID, Argentina
Centro Cardiovascular Salta
Salta, 4406, Argentina
CORDIS S.A., Salta
Salta, A4400ANW, Argentina
Prevencion Cardiovascular Salta, Salta
Salta, A4400CRC, Argentina
Investigaciones Clinicas Tucuman
San Miguel de Tucumán, T4000ICL, Argentina
CCBR Tucuman
San Miguel de Tucumán, T4000, Argentina
Instituto de Investigaciones Clinicas San Nicolas
San Nicolás, B2900DMH, Argentina
Centro Medico Luquez
San Vicente, X5006CBI, Argentina
Centro de Investigaciones Clínicas del Litoral
Santa Fe, S3000FWO, Argentina
Hospital "Dr. José Maria Cullen "
Santa Fé, S3000EOZ, Argentina
Clinica Privada Fusavim SRL
Villa María, X5900JKA, Argentina
Instituto de Investigaciones Clínicas Zárate
Zárate, 2800, Argentina
Hospital Universitário João de Barros Barreto
Belém, 66073-000, Brazil
Hospital Felício Rocho
Belo Horizonte, 30110-060, Brazil
Hospital Lifecenter
Belo Horizonte, 30110-921, Brazil
Hospital Vera Cruz
Belo Horizonte, 30140-062, Brazil
Hospital Angelina Caron
Campina Grande do Sul, 83430-000, Brazil
HMCP - Hospital e Maternidade Celso Pierro - PUC-Campinas
Campinas, 13060-904, Brazil
CAEP - Centro Avançado de Estudos e Pesquisas Ltda.,Campinas
Campinas, 13087-567, Brazil
Hospital Universitário
Canoas, 92425-900, Brazil
Universidade de Caxias do Sul - IPCEM - Inst. de Pesq.clilni
Caxias do Sul, 95070-560, Brazil
Hospital de Caridade Santa Casa de Misericordia de Curitiba
Curitiba, 80010-030, Brazil
HC UFPR
Curitiba, 80030-110, Brazil
Cruz Vermelha Brasileira - Filial do Estado do Paraná
Curitiba, 80030-480, Brazil
Centro de Estudos em Diabetes e Hipertensão
Fortaleza, 60115-282, Brazil
Centro de Pesquisas em Diabetes e Doenças
Fortaleza, 60430-350, Brazil
ICE-HUWC - Instituto Cearense de Endocrinologia
Fortaleza, 60430-370, Brazil
Via Médica
Goiânia, 74223-130, Brazil
Hospital Bruno Born
Lajeado, 95900-000, Brazil
ICM - Instituto do Coração de Marília
Marília, 17515-000, Brazil
Hospital São Vicente de Paulo
Passo Fundo, 99010-080, Brazil
Irmandade da Santa Casa de Misericórdia de Porto Alegre
Porto Alegre, 90035-074, Brazil
Centro de Pesquisas em Diabetes
Porto Alegre, 90035-170, Brazil
Instituto de Cardiologia Rio Grande do Sul
Porto Alegre, 90620-001, Brazil
Centro de Pesquisas Médicas Básica e Clínica Ltda
Recife, 52020-010, Brazil
CCBR - Rio de Janeiro - BR
Rio de Janeiro, 22271-100, Brazil
Centro de Pesquisa Clínica Santa Maria
Santa Maria, 97015-530, Brazil
CCBR Brasil - São Paulo
Santo André, 09190510, Brazil
Instituto Domingo Braile
São José do Rio Preto, 15015-750, Brazil
Fundacao Faculdade Regional de Medicina, Sao Jose
São José do Rio Preto, 15090-000, Brazil
Cpquali Pesquisa Clinica Ltda
São Paulo, 01228-000, Brazil
Centro de Pesquisa Clinica - CPCLIN
São Paulo, 01244-030, Brazil
Hospital Alemao Oswaldo Cruz
São Paulo, 01323-903, Brazil
FGM Clínica Paulista de Doenças Cardiovasculares LTDA
São Paulo, 01327-010, Brazil
Hospital Sao Paulo - UNIFESP
São Paulo, 04022-001, Brazil
Hospital do Servidor Público Estadual
São Paulo, 04039-901, Brazil
Dr. Consulta
São Paulo, 04254-020, Brazil
Hospital das Clinicas da FMUSP
São Paulo, 05403-000, Brazil
Incor - Instituto do Coração - HCFMUSP
São Paulo, 05403-000, Brazil
IMC - Instituto de Moléstias Cardiovasculares Tatuí
Tatuí, 18270-170, Brazil
ICT - Instituto do Coração do Triângulo
Uberlândia, 38400-368, Brazil
MHAT - Blagoevgrad, EOOD
Blagoevgrad, 2700, Bulgaria
MHAT "Yuliya Vrevska" EOOD, Byala
Byala, 7100, Bulgaria
MHAT "Dr.Stambolski", Cardiology&Intensiv Care Dept,Kazanlak
Kazanlak, 6100, Bulgaria
UMHAT "Kaspela", EOOD, Plovdiv
Plovdiv, 4002, Bulgaria
DCC 1 - Ruse, EOOD
Rousse, 7002, Bulgaria
Fifth MHAT - Sofia EAD, Sofia
Sofia, 1233, Bulgaria
MHAT Lyulin
Sofia, 1336, Bulgaria
MHAT 'Tokuda Hospital Sofia', EAD
Sofia, 1407, Bulgaria
USHATE Hospital 'Academy Ivan Penchev', Sofia
Sofia, 1431, Bulgaria
DCC "Equita" EOOD
Varna, 9000, Bulgaria
ALTA Clinical Research Inc.
Edmonton, Alberta, T5A 4L8, Canada
The Bailey Clinic
Red Deer, Alberta, T4N 6V7, Canada
Dr. Ronald Collette
Burnaby, British Columbia, V5G 1T4, Canada
The Medical Arts Health Research Group
Penticton, British Columbia, V2A5G8, Canada
LMC Clinical Research dba Manna Research Inc. Vancouver
Vancouver, British Columbia, V6J 1S3, Canada
Fraser Clinical Trials Inc.
Victoria, British Columbia, V8R 4R2, Canada
Discovery Clinical Services Ltd.
Victoria, British Columbia, V8T 5G4, Canada
CookMed Research
Victoria, British Columbia, V8V 4A1, Canada
Winnipeg Regional Health Authority, Winnipeg
Winnipeg, Manitoba, R3E 3P4, Canada
True North Clinical Research Halifax, Inc.
Halifax, Nova Scotia, B3S 1M7, Canada
LMC Endocrinology Centres (Barrie) Ltd.
Barrie, Ontario, L4N 7L3, Canada
JBN Medical Diagnostic Services Inc.
Burlington, Ontario, L7M 4Y1, Canada
LMC Endocrinology Centres (Etobicoke) Ltd.
Etobicoke, Ontario, M9R 4E1, Canada
Medicor Research
Greater Sudbury, Ontario, P3E 1H5, Canada
Sudbury Cardiac Research
Greater Sudbury, Ontario, P3E 2N8, Canada
Dr. R. Labonte Prof. Med. Corp
Greater Sudbury, Ontario, P3E 3B8, Canada
LMC Endocrinology Centres (Markham) Ltd.
Markham, Ontario, L6B 0P9, Canada
SKDS Research Incorporated
Newmarket, Ontario, L3Y 5G8, Canada
ViaCar Recherche Clinique Inc
Brossard, Quebec, J4Z 2K9, Canada
Hopital Charles - LeMoyne
Greenfield Park, Quebec, J4V 2G9, Canada
Centre De Recherche Clinique
Laval, Quebec, H7T 2P5, Canada
Recherche Invascor Inc.
Longueuil, Quebec, J4N 1C2, Canada
Centre Hospitalier de l'Universite de Montreal (CHUM)
Montreal, Quebec, H2X 0A9, Canada
McGill University Health Centre (MUHC)
Montreal, Quebec, H4A 3J1, Canada
St Jerome Medical Research Inc.
Saint-Jérôme, Quebec, J7Z 5T3, Canada
LMC Endocrinology Centres (Montreal)
Saint-Laurent, Quebec, H4T 1Z9, Canada
Recherche Clinique Sigma Inc.
Québec, G1G 3Y8, Canada
Clinique des maladies Lipidiques de Quebec
Québec, G1V 4M6, Canada
Hospital Regional de Punta Arenas Dr. Lautaro Navarro Avaria
Punta Arenas, 6200000, Chile
Hospital El Pino
Santiago, 0, Chile
Sociedad Medica Cardiologica El Llano
Santiago, 0, Chile
Hospital Militar de Santiago
Santiago, 7850000, Chile
Hospital Sotero del Rio
Santiago, 8150000, Chile
CeCim - Centro de Estudios Clinicos e Investigacion Medica
Santiago, 8331143, Chile
Hospital Padre Alberto Hurtado
Santiago, 8880465, Chile
Hospital Base Valdivia
Valdivia, 5090000, Chile
Hospital Naval Almirante Nef
Viña del Mar, 2520000, Chile
Beijing Jishuitan Hospital
Beijing, 100035, China
Third Affiliated Hospital of Guangzhou Medical University
Guangzhou, 510150, China
Zhejiang University School of Medicine SIR RUN RUN SHAW Hospital
Hangzhou, 310016, China
Center Hospital of Jinan
Jinan, 250013, China
People's Hospital of Guangxi Zhuang Autonomous Region
Nanning, 530021, China
Tongji Hospital, Tongji University
Shanghai, 200065, China
First Affiliated Hospital of Xi'an JiaoTong University
Xi'an, 710061, China
General Hospital of Ningxia Medical University
Yinchuan, 750004, China
CEQUIN
Armenia, 55860, Colombia
Corazon IPS S.A.S.
Barranquilla, 0000, Colombia
Clínica de la Costa Ltda.
Barranquilla, 0, Colombia
IPS Centro Cientifico Asistencia
Barranquilla, 80020, Colombia
Centro de Atencion e Investigacion Medica S.A. - CAIMED
Bogotá, 0, Colombia
CAFESALUD Medicina Prepagada S.A.
Bogotá, 110221, Colombia
Dexa Diabetes Servicios Médicos Ltda
Bogotá, 110221, Colombia
Solano y Terront Servicios Médicos Ltda.
Bogotá, 110221, Colombia
Fundacion Reina Isabel
Cali, 0, Colombia
IPS Centro Medico Julián Coronel S.A.
Cali, 0, Colombia
Fundación Centro de Investigaciones Biomédicas Riescard
Espinal, 0, Colombia
Centro de Investigacion Clínica Avanzada
Medellín, 0, Colombia
Fundacion Centro de Investigacion Clinica CIC, Medellin
Medellín, 50021, Colombia
Fundacion Centro de Obesidad y Metabolismo - COMETA
Pasto, 52002, Colombia
Healthy Medical CenterS.A.S, Zipaquirá
Zipaquirá, 0, Colombia
General Hospital Karlovac
Karlovac, 47000, Croatia
Hospital for Medical Rehabilitation, Krapinske Toplice
Krapinske Toplice, 49217, Croatia
General Hospital Slavonski Brod
Slavonski Brod, 35000, Croatia
General Hospital Varazdin
Varaždin, 42000, Croatia
General Hosp. Zadar, Dept. of Internal Medicine-Pulmonology
Zadar, 23000, Croatia
Clinical Hospital Sveti Duh
Zagreb, 10000, Croatia
University hospital center Zagreb
Zagreb, 10000, Croatia
Fakultni nemocnice u sv. Anny v Brne
Brno, 656 91, Czechia
Fakultni nemocnice u sv. Anny v Brne
Brno, 65691, Czechia
Revmatologie Bruntal, s.r.o.
Bruntál, 792 01, Czechia
Poliklinika Chocen, a.s.
Choceň, 56501, Czechia
Aesculap Ambulance Sro
Dolní Břežany, 252 41, Czechia
OKELI s.r.o.
Hodonín, 695 01, Czechia
Nemocnice Jindrichuv Hradec a.s.
Jindřichův Hradec, 377 01, Czechia
Regional Hospital Liberec
Liberec, 460 63, Czechia
InterKardioML s.r.o.
Mariánské Lázně, 353 01, Czechia
Interna a diabetologicka ordinace s.r.o.
Náchod, 547 01, Czechia
PreventaMed, s.r.o.
Olomouc, 77900, Czechia
Univ. Hospital Kralovske Vinohrady
Prague, 100 34, Czechia
Vseobecna fakultni nemocnice V Praze
Prague, 128 08, Czechia
ResTrial s.r.o.
Prague, 181 00, Czechia
Thomayer Hospital
Praha 4 - Krc, 140 59, Czechia
Hospital Slany, Internal Department
Slaný, 274 01, Czechia
Krajska zdravotni, a.s. - Nemocnice Teplice, o.z.
Teplice, 41501, Czechia
Studienzentrum Aschaffenburg
Aschaffenburg, 63739, Germany
Zentrum für klinische Forschung Dr. med. Irma Schöll & Kollegen
Bad Homburg, 61348, Germany
Universitätsklinikum Carl Gustav Carus Dresden
Dresden, 1307, Germany
ClinPhenomics GmbH & Co KG, Frankfurt
Frankfurt, 60594, Germany
IKF Pneumologie GmbH & Co. KG
Frankfurt am Main, 60596, Germany
Diabetologische Schwerpunktpraxis, Hohenmölsen
Hohenmölsen, 6679, Germany
EUGASTRO GmbH, Leipzig
Leipzig, 4103, Germany
Gemeinschaftspraxis Dr. Taeschner / Dr. Bonigut, Leipzig
Leipzig, 4249, Germany
Lausmed Kft. Outpatient Unit of Internal Medicine
Baja, 6500, Hungary
Dr. Kenessey Albert Kórház-Rendelõintézet, Balassagyarmat
Balassagyarmat, 2660, Hungary
DRC Gyogyszervizsgalo Kozpont Kft., Balatonfured
Balatonfüred, 8230, Hungary
Clinexpert Kft.
Budapest, 1033, Hungary
Obudai Egeszsegugyi Centrum
Budapest, 1036, Hungary
QUALICLINIC Kft
Budapest, 1036, Hungary
Semmelweis Egyetem, Budapest
Budapest, 1083, Hungary
Semmelweis Egyetem, Budapest
Budapest, 1088, Hungary
Semmelweis Egyetem, Budapest
Budapest, 1125, Hungary
University Debrecen Hospital
Debrecen, 4032, Hungary
Markhot Ferenc Hospital, Eger
Eger, 3300, Hungary
Csongrad Megyei Eu. Ellato Kozp. Hodmezovasarhely-Mako
Hódmezővásárhely, 6800, Hungary
Somogy Megyei Kaposi Mor Oktato Korhaz, Kaposvar
Kaposvár, 7400, Hungary
Selye Janos Hospital Komarom
Komárom, 2900, Hungary
Ermellek Egeszsegcentrum
Létavértes, 4281, Hungary
Borsod-Abauj-Zemplen Megyei Korhaz es Egyetemi Oktato Korhaz
Miskolc, 3526, Hungary
Pecsi Tudomanyegyetem
Pécs, 7624, Hungary
Szegedi Tudomanyegyetem Szent-Gyorgyi Albert Klin. Kozpont
Szeged, 6725, Hungary
Zala Megyei Szent Rafael Korhaz
Zalaegerszeg, 8900, Hungary
Haemek Medical Center
Afula, 18101, Israel
Bnei Zion Medical Center, Haifa
Haifa, 31048, Israel
Rambam Medical Center
Haifa, 3109601, Israel
Herzliya Medical Center
Herzliya, 4685107, Israel
Wolfson Medical Center
Holon, 58100, Israel
Hadassah Medical Center, Ein-Karem
Jerusalem, 9112001, Israel
Meir Medical Center
Kfar Saba, 4428164, Israel
Galilee Medical Center
Nahariya, 2210001, Israel
Ziv Medical Center
Safed, 13100, Israel
Sourasky Medical Center
Tel Aviv, 6423906, Israel
Daishinkai Medical Corporation Ookuma Hospital
Aichi, Nagoya, 462-0825, Japan
Seikeikai New Tokyo Heart Clinic
Chiba, Matsudo, 271-0077, Japan
Saiseikai Matsuyama Hospital
Ehime, Matsuyama, 791-8026, Japan
Aso Co.,Ltd Iizuka Hospital
Fukuoka, Iizuka, 820-8505, Japan
Kitakyushubyoin Kitakyushu General Hospital
Fukuoka, Kitakyushu, 800-0295, Japan
The Veritas Hospital
Hyogo, Kawanishi, 666-0125, Japan
Ibaraki Seinan Medical Center Hospital
Ibaraki, Sashima-gun, 306-0433, Japan
Kokan Clinic
Kanagawa, Kawasaki, 210-0852, Japan
Nagano Red Cross Hospital
Nagano, Nagano, 380-8582, Japan
Josuikai Olive Takamatsu Medical Clinic
Takamatsu, 760-0076, Japan
Hospital Sultanah Bahiyah
Alor Star, 5460, Malaysia
Hospital Tengku Ampuan Rahimah
Klang, 41200, Malaysia
University Malaya Medical Centre
Kuala Lumpur, 59100, Malaysia
Hospital Tengku Ampuan Afzan
Kuantan, 25100, Malaysia
Monash University(Sunway Campus)
Petaling Jaya, 46150, Malaysia
Hospital Pulau Pinang
Pulau Pinang, 10450, Malaysia
Universiti Putra Malaysia
Serdang, 43400, Malaysia
Hospital Seri Manjung
Seri Manjung, 32040, Malaysia
Hospital Taiping
Taiping, 34000, Malaysia
Klinik Kesihatan Tampin
Tampin, 73009, Malaysia
Investigación en Salud y Metabolismo S.C.
Chihuahua City, 31237, Mexico
Phylasis Clinicas Research S de RL de CV
Cuautitlán Izcalli, 54769, Mexico
Centro para el Desarrollo de la Medicina y de Asist Med Espe
Culiacán, CP80020, Mexico
Centro de Investigacion Biomedica y Farmaceutica, S.C.
Distrito Federal, 03100, Mexico
Servicios Medicos de la Pena SC
Guadalajara, 44690, Mexico
Medical Care & Research SA de CV
Mérida, 97070, Mexico
Sociedad de Cirugia Vascular Plastica Reconstructiva
Mérida, 97129, Mexico
Phytomedicamenta S.A. de C.V.
México, 03100, Mexico
Comite Mexicano Para la Prevencion de Osteoporosis AC
México, 06100, Mexico
Centro de Atención e Investigación en Factores de Riesgo
México, 06700, Mexico
Clinstile S.A. de C.V.
México, 06700, Mexico
Ultimate Medica SA de CV
México, 11850, Mexico
Health Pharma Professional Research S.A. de C.V.
México, 3810, Mexico
Centro de Estudios Clinicos y Especialidades Medicas, S.C.
Monterrey, 64620, Mexico
AVIX Investigación Clínica S.C
Monterrey, 64710, Mexico
Global Trial Research Center S.A. de C.V.
Monterrey, 64718, Mexico
Centro de Investigacion Clinica Chapultepec S. A. de C. V.
Morelia, 58260, Mexico
Centro de Estudios Clínicos de Queretaro S.C., CECLIQ
Querétaro, 76000, Mexico
Centro de Investigacion Cardiovascular y Metabolica
Tijuana, 22500, Mexico
Centro de Investigación Médica de Ocidente, S.C.
Zapopan, 45116, Mexico
Hospital Dr Angel Leano
Zapopan, 45200, Mexico
Rijnstate Hospital
Arnhem, 6815 AD, Netherlands
Albert SchweitzerZiekenhuis
Dordrecht, 3318 AT, Netherlands
Universitair Medisch Centrum Groningen
Groningen, 9713 GZ, Netherlands
Martini Ziekenhuis
Groningen, 9728 NT, Netherlands
Bethesda Cardiology Group, Hoogeveen
Hoogeveen, 7909 AA, Netherlands
Maastricht Universitair Medisch Centrum
Maastricht, 6229 HX, Netherlands
Rotterdam Research Institute
Rotterdam, 3039 BD, Netherlands
Universitair Medisch Centrum Utrecht
Utrecht, 3584 CX, Netherlands
TweeSteden Ziekenhuis
Waalwijk, 5141 BM, Netherlands
Gelre Ziekenhuis Zutphen
Zutphen, 7207 BA, Netherlands
B_Serwis Popenda Sp.Jawna
Chorzów, 41-500, Poland
Poradnia Kardiologiczna Jaroslaw Jurowiecki
Gdansk, 80-286, Poland
University Clinical Center, Gdansk
Gdansk, 80-952, Poland
Indywidualna Specjalistyczna Praktyka Lekarska
Gdynia, 81-157, Poland
MCBK Iwona Czajkowska Anna Podrazka- Szczepaniak S.C.
Grodzisk Mazowiecki, 05-825, Poland
Centrum Medyczne Pratia Katowice II
Katowice, 40-084, Poland
Polimedica Centrum Bada?, Profilaktyki I Leczenia
Kielce, 25-364, Poland
NZOZ Centrum Medyczne ProMiMed Sp. z o.o., Sp.k., Krakow
Krakow, 31-637, Poland
Centrum Terapii Wspolczesnej J.M.
Lodz, 90-242, Poland
CCBR - Lodz - PL, Lodz
Lodz, 90-368, Poland
Individual Specialized Practice
Lodz, 94-255, Poland
Centrum Medyczne "Luxmed" Sp. z o.o.
Lublin, 20-109, Poland
KO-MED Centra Kliniczne Lublin II
Lublin, 20-362, Poland
NZOZ Specialized Ambulance "MEDICA"
Lublin, 20-538, Poland
RCMed- Regionalne Centrum Medyczne
Nowy Duninów, 09-505, Poland
Medicome Sp. z o.o.
Oświęcim, 32-600, Poland
Prywatny Gabinet Lekarski Lech Lazuka
Parczew, 21-200, Poland
Clin.Hosp.Med.Univ.Marcinkowski in Poznan
Poznan, 60-569, Poland
Praktyka Lekarska Ewa Krzyzagorska
Poznan, 61-655, Poland
KOMED Marek Konieczny
Puławy, 24-100, Poland
Indywidualna Specjalistyczna Praktyka Lekarska Dr N Med Andrzej Wittek
Ruda Śląska, 41-709, Poland
Centrum Medyczne Medyk
Rzeszów, 35-055, Poland
RCMed- Regionalne Centrum Medyczne
Sochaczew, 96-500, Poland
KO-MED Centra Kliniczne Staszow
Staszów, 28-200, Poland
NSZOZ Medicus
Środa Wielkopolska, 63-000, Poland
Lecznice Citomed Sp. z o.o.
Torun, 87-100, Poland
NZOZ Nasz Lekarz
Torun, 87-100, Poland
NBR Polska
Warsaw, 00-465, Poland
CCBR/Somed - Warszaw - PL
Warsaw, 04-730, Poland
Regionalna Poradnia Diabetoloiczna Zytkiewicz-Jaruga
Wroclaw, 50-127, Poland
KO-MED Centra Kliniczne Zamosc
Zamość, 22-400, Poland
Polimedica Centrum Bada?, Profilaktyki I Leczenia
Zgierz, 95-100, Poland
Hospital de Braga-Escala Braga
Braga, 4710-243, Portugal
CHUC - Centro Hospitalar e Universitário de Coimbra, EPE
Coimbra, 3000-075, Portugal
APDP - Associação Protectora dos Diabéticos de Portugal
Lisbon, 1250-203, Portugal
CHLO, EPE - Hospital S. Francisco Xavier
Lisbon, 1449-005, Portugal
Hospital da Luz
Lisbon, 1500-650, Portugal
Hospital CUF Porto
Porto, 4100-180, Portugal
Centro Hospitalar de Vila Nova de Gaia
V. N. Gaia, 4434-502, Portugal
SC Diana Barbonta SRL, Alba Iulia
Alba Iulia, 510053, Romania
Spitalul Universitar de Urgenta, Bucuresti
Bucharest, 010825, Romania
I.N.D.N.B.M. "Prof. Dr. N.C. Paulescu" - Sediul Central
Bucharest, 011234, Romania
I.N.D.N.B.M. "Prof. Dr. N.C. Paulescu" - Sediul Central
Bucharest, 020475, Romania
CMI Dr. Stolea T. Violeta
Bucharest, 061072, Romania
Clinica Medicala Data Plus SRL
Bucharest, 10192, Romania
I.N.D.N.B.M. "Prof. Dr. N.C. Paulescu" - Sediul "I.L. Caragiale"
Bucharest, 20045, Romania
S.C Centrul Medical "Sanatatea Ta" S.R.L
Bucharest, 20614, Romania
S.C. Policlinica CCBR SRL, Bucuresti
Bucharest, 30463, Romania
Medcon SRL
Buzău, 120203, Romania
Spitalul Clinic Judetean de Urgenta ¿Sf. Apostol Andrei¿
Galati, 800578, Romania
Spitalul Clinic, Iasi
Iași, 700503, Romania
Consultmed SRL, Iasi
Iași, 700547, Romania
SC Diaconu-Sotropa Michaela, Cabinet de Diabet
Iași, 700613, Romania
S.C Grandmed S.R.L, Oradea
Oradea, 410159, Romania
Pelican Impex SRL, Cabinet Nr. 15
Oradea, 410469, Romania
S.C Anamed S.R.L
Oradea, 410491, Romania
S.C. Diabmed Dr. Popescu Alexandrina S.R.L
Ploieşti, 100163, Romania
Gensan SRL
Sibiu, 550371, Romania
Mediab SRL
Târgu Mureş, 540142, Romania
Centrul Medical Dr Negrisanu SRL
Timișoara, 300456, Romania
SBEI HPE Altay State Medical University of MoH and SD
Barnaul, 656038, Russia
Res.Inst.-Compl.Iss.Cardi.Dis.
Kemerovo, 650002, Russia
NSIH "Departmental Hospital on Station Kemerovo of OJSC "Russian Railways"
Kemerovo, 650055, Russia
First Moscow State Medical University n.a. I.M. Sechenov
Moscow, 119435, Russia
Moscow 1st State Med.Univ.n.a.I.M.Sechenov
Moscow, 119992, Russia
SBEI HPE "Moscow State Medical and Dentistry University
Moscow, 127473, Russia
Moscow State Medical Dentistry University
Moscow, 129301, Russia
SBIH of Novosibirsk Region "Clinical Emergency Hospital #2"
Novosibirsk, 630008, Russia
Novosibirsk Regional Clinical Cardiological Dispansary
Novosibirsk, 630047, Russia
FSBSI "Scientific Research Institute", Novosibirsk
Novosibirsk, 630089, Russia
FSBSI "Scientific and Research Institute of Physiology and Basic Medicine"
Novosibirsk, 630117, Russia
BIH of OR "City Hospital # 2", Omsk
Omsk, 644021, Russia
SBIH of Perm territory " City Clinical Hospital # 2 n.a.
Perm, 614068, Russia
SBI of Ryazan region "Regional Clinical Cardiological Dis.
Ryazan, 390026, Russia
FSBMEI HPE "Military Medical Academy n.a. S.M. Kirov"
Saint Petersburg, 194044, Russia
Medical Research Institute LLC, St. Petersburg
Saint Petersburg, 196084, Russia
1stPavlov St.Med.Univ.St.-Petersburg Res.Inst.
Saint Petersburg, 197022, Russia
Federal North-West Medical Research Centre
Saint Petersburg, 197341, Russia
SPb SBHI "City Policlinic #74"
Saint Petersburg, 197762, Russia
SPb SBIH "City Pokrovskaya Hospital"
Saint Petersburg, 199106, Russia
GUZ "City Clinical Hospital #40, 197706 Saint-Petersburg
Sestroretsk, 197706, Russia
FSBI "Research Institute for Cardiology"
Tomsk, 634012, Russia
Cardiology Clinical Research
Alberton, 1449, South Africa
Iatros International
Bloemfontein, 9301, South Africa
Limaro Research
Bloemfontein, 9301, South Africa
Dr JM Engelbrecht Practice
Cape Town, 7129, South Africa
Dr Dawood, Mohamed and Pillay
Cape Town, 7405, South Africa
TREAD Research
Cape Town, 7500, South Africa
Langeberg Clinical Trials
Cape Town, 7570, South Africa
Cape Town Medical Research Centre
Cape Town, 7580, South Africa
Ismail, SM
Cape Town, 7764, South Africa
Groote Schuur Hospital
Cape Town, 7925, South Africa
Latiff, GHVM
Durban, 4001, South Africa
Londisizwe Research Centre, Durban
Durban, 4001, South Africa
Diabetes Care Centre
Johannesburg, 1501, South Africa
Wits Clinical Research Chris Hani Baragwanath Hospital
Johannesburg, 2013, South Africa
WCR CMJAH Clinical Trial Site
Johannesburg, 2193, South Africa
DJW Navorsing
Krugersdorp, 1739, South Africa
Emmed Research
Pretoria, 0002, South Africa
University of Pretoria
Pretoria, 0002, South Africa
Syzygy Clinical Research Services
Pretoria, 0087, South Africa
Into Research
Pretoria, 181, South Africa
Seeber, M
Pretoria, 2, South Africa
Dr M Duki Research and Trial Site, Verulam
Verulam, 4339, South Africa
Clinical Projects Research
Worcester, 6850, South Africa
Hallym University Sacred Heart Hospital
Anyang-si, 431-070, South Korea
Inje University Busan Paik Hospital
Busan, 47392, South Korea
Dong-A University Hospital
Busan, 602-715, South Korea
Pusan National Univ. Hosp
Busan, 602-739, South Korea
Myongji Hospital
Goyang-si, 412-270, South Korea
Gachon University Gil Medical Center
Incheon, 21565, South Korea
The Catholic University of Korea, Seoul St.Mary's Hospital
Seoul, 06591, South Korea
Seoul National University Hospital
Seoul, 110744, South Korea
Asan Medical Center
Seoul, 138736, South Korea
Korea University Anam Hospital
Seoul, 2841, South Korea
Korea University Guro Hospital
Seoul, 8308, South Korea
Wonju Severance Christian Hosp
Wŏnju, 26426, South Korea
Hospital Virgen del Mar
Almería, 04120, Spain
Hospital de la Ribera
Alzira, 46600, Spain
Hospital Germans Trias i Pujol
Badalona, 08916, Spain
Specialist
Barcelona, 08006, Spain
CAP Sarria
Barcelona, 08017, Spain
Hospital Quiron. I.C.U.
Barcelona, 08023, Spain
EBA Centelles
Centelles, 08540, Spain
Fundación Jiménez Díaz
Madrid, 28040, Spain
Hospital Regional Universitario de Málaga
Málaga, 29010, Spain
Hospital General de Segovia
Segovia, 40002, Spain
Hospital Quironsalud Infanta Luisa
Seville, 41010, Spain
Hospital Virgen Macarena
Seville, 41071, Spain
Hospital General Universitario de Valencia
Valencia, 46014, Spain
Hospital Dr. Peset
Valencia, 46017, Spain
Hospital Virgen de las Montañas, Villamartin
Villamartín, 11650, Spain
Kaohsiung Medical University Chung-Ho Memorial Hospital
Kaohsiung City, 807, Taiwan
Kaohsiung Veterans General Hospital
Kaohsiung City, 81362, Taiwan
Far Eastern Memorial Hospital
New Taipei City, 220, Taiwan
China Medical University Hospital
Taichung, 404, Taiwan
NCKUH
Tainan, 704, Taiwan
National Taiwan University Hospital
Taipei, 100, Taiwan
Taipe Veterans General Hospital
Taipei, 11217, Taiwan
Chang-Gung Memorial Hospital, Linkou
Taoyuan, 333, Taiwan
Chernivtsi Regional Endocrinology Dispensary
Chernivtsi, 58022, Ukraine
Regional CH Dept of Endocrinology SHEI Ivano-Frankivsk NMU
Ivano-Frankivsk, 76008, Ukraine
CI Ivano-Frankivsk Reg Cl Card Center
Ivano-Frankivsk, 76018, Ukraine
L.T. Malaya Institute of Therapy AMS of Ukraine
Kharkiv, 61039, Ukraine
CIPH Prof. O.I. Meshchaninov Kharkiv CCH of A&E
Kharkiv, 61103, Ukraine
CI of Healthcare Kharkiv CCH #8, Kharkiv
Kharkiv, 61176, Ukraine
KCCC of Endocr Dept of General Endocrine Pathology
Kyiv, 01004, Ukraine
City Clinical Hospital No. 1, Kiev
Kyiv, 02091, Ukraine
V.P. Komisarenko Inst. of Endocrinology and Metabolism
Kyiv, 04114, Ukraine
Kjiv City Oleksandrivska Clinical Hospital
Kyiv, 1601, Ukraine
LLC Treatment and Diagnostic Center Adonis Plus, Kyiv
Kyiv, 2002, Ukraine
SI National Scientific Centre of Radiation Medicine of NAMSU
Kyiv, 3115, Ukraine
P.L. Shupyk NMA of PGE Ch of D H for S-ts of NASU
Kyiv, 4050, Ukraine
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Related Publications (10)
Marx N, Kolkailah AA, Rosenstock J, Johansen OE, Cooper ME, Alexander JH, Toto RD, Wanner C, Espeland MA, Mattheus M, Schnaidt S, Perkovic V, Gollop ND, McGuire DK. Hypoglycemia and Cardiovascular Outcomes in the CARMELINA and CAROLINA Trials of Linagliptin: A Secondary Analysis of Randomized Clinical Trials. JAMA Cardiol. 2024 Feb 1;9(2):134-143. doi: 10.1001/jamacardio.2023.4602.
PMID: 38170502DERIVEDBalasubramanian P, Kernan WN, Sheth KN, Ofstad AP, Rosenstock J, Wanner C, Zinman B, Mattheus M, Marx N, Inzucchi SE. Baseline Cardiovascular Risk Factor Control in Patients With Type 2 Diabetes and Coronary Disease Versus Stroke: Secondary Analysis of Cardiovascular Outcome Trials. Stroke. 2023 Aug;54(8):2013-2021. doi: 10.1161/STROKEAHA.122.042053. Epub 2023 Jul 14.
PMID: 37449424DERIVEDDar MS, Wanner C, Marx N, Ofstad AP, Mattheus M, Kaspers S, Beg SA. Cardiovascular outcomes trial data from EMPA-REG OUTCOME, CAROLINA and CARMELINA: Assessment of a novel staging system for type 2 diabetes. Diabetes Obes Metab. 2023 May;25(5):1372-1384. doi: 10.1111/dom.14989. Epub 2023 Mar 6.
PMID: 36700391DERIVEDVerhagen C, Janssen J, Minderhoud CA, van den Berg E, Wanner C, Passera A, Johansen OE, Biessels GJ. Chronic kidney disease and cognitive decline in patients with type 2 diabetes at elevated cardiovascular risk. J Diabetes Complications. 2022 Oct;36(10):108303. doi: 10.1016/j.jdiacomp.2022.108303. Epub 2022 Aug 31.
PMID: 36116359DERIVEDVerhagen C, Janssen J, Exalto LG, van den Berg E, Johansen OE, Biessels GJ. Diabetes-specific dementia risk score (DSDRS) predicts cognitive performance in patients with type 2 diabetes at high cardio-renal risk. J Diabetes Complications. 2020 Oct;34(10):107674. doi: 10.1016/j.jdiacomp.2020.107674. Epub 2020 Jul 16.
PMID: 32723590DERIVEDPerkovic V, Toto R, Cooper ME, Mann JFE, Rosenstock J, McGuire DK, Kahn SE, Marx N, Alexander JH, Zinman B, Pfarr E, Schnaidt S, Meinicke T, von Eynatten M, George JT, Johansen OE, Wanner C; CARMELINA investigators. Effects of Linagliptin on Cardiovascular and Kidney Outcomes in People With Normal and Reduced Kidney Function: Secondary Analysis of the CARMELINA Randomized Trial. Diabetes Care. 2020 Aug;43(8):1803-1812. doi: 10.2337/dc20-0279. Epub 2020 May 22.
PMID: 32444457DERIVEDBiessels GJ, Verhagen C, Janssen J, van den Berg E, Zinman B, Rosenstock J, George JT, Passera A, Schnaidt S, Johansen OE; CARMELINA Investigators. Effect of Linagliptin on Cognitive Performance in Patients With Type 2 Diabetes and Cardiorenal Comorbidities: The CARMELINA Randomized Trial. Diabetes Care. 2019 Oct;42(10):1930-1938. doi: 10.2337/dc19-0783. Epub 2019 Aug 9.
PMID: 31399442DERIVEDMcGuire DK, Alexander JH, Johansen OE, Perkovic V, Rosenstock J, Cooper ME, Wanner C, Kahn SE, Toto RD, Zinman B, Baanstra D, Pfarr E, Schnaidt S, Meinicke T, George JT, von Eynatten M, Marx N; CARMELINA Investigators. Linagliptin Effects on Heart Failure and Related Outcomes in Individuals With Type 2 Diabetes Mellitus at High Cardiovascular and Renal Risk in CARMELINA. Circulation. 2019 Jan 15;139(3):351-361. doi: 10.1161/CIRCULATIONAHA.118.038352.
PMID: 30586723DERIVEDRosenstock J, Perkovic V, Johansen OE, Cooper ME, Kahn SE, Marx N, Alexander JH, Pencina M, Toto RD, Wanner C, Zinman B, Woerle HJ, Baanstra D, Pfarr E, Schnaidt S, Meinicke T, George JT, von Eynatten M, McGuire DK; CARMELINA Investigators. Effect of Linagliptin vs Placebo on Major Cardiovascular Events in Adults With Type 2 Diabetes and High Cardiovascular and Renal Risk: The CARMELINA Randomized Clinical Trial. JAMA. 2019 Jan 1;321(1):69-79. doi: 10.1001/jama.2018.18269.
PMID: 30418475DERIVEDRosenstock J, Perkovic V, Alexander JH, Cooper ME, Marx N, Pencina MJ, Toto RD, Wanner C, Zinman B, Baanstra D, Pfarr E, Mattheus M, Broedl UC, Woerle HJ, George JT, von Eynatten M, McGuire DK; CARMELINA(R) investigators. Rationale, design, and baseline characteristics of the CArdiovascular safety and Renal Microvascular outcomE study with LINAgliptin (CARMELINA(R)): a randomized, double-blind, placebo-controlled clinical trial in patients with type 2 diabetes and high cardio-renal risk. Cardiovasc Diabetol. 2018 Mar 14;17(1):39. doi: 10.1186/s12933-018-0682-3.
PMID: 29540217DERIVED
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Results Point of Contact
- Title
- Boehringer Ingelheim, Call Center
- Organization
- Boehringer Ingelheim
Study Officials
- STUDY CHAIR
Boehringer Ingelheim
Boehringer Ingelheim
Publication Agreements
- PI is Sponsor Employee
- No
- Restriction Type
- OTHER
- Restrictive Agreement
- Yes
Study Design
- Study Type
- interventional
- Phase
- phase 4
- Allocation
- RANDOMIZED
- Masking
- DOUBLE
- Who Masked
- PARTICIPANT, INVESTIGATOR
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- INDUSTRY
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
July 9, 2013
First Posted
July 12, 2013
Study Start
July 10, 2013
Primary Completion
January 18, 2018
Study Completion
January 18, 2018
Last Updated
April 4, 2019
Results First Posted
January 25, 2019
Record last verified: 2019-03