Computational Modeling for Prediction of Acoustic Changes in Vowel Production Due to Orthognathic Surgery

NCT01887977 | Unknown

• 1 other identifier: T17/2012
• Study Type: interventional
• Target: 20
• Locations: 1 country
• Sites: 1

Brief Summary

A computational model of human sound production based on high quality anatomic measurements and physical laws of sound propagation cannot be accomplished without a comprehensive data set including both 3D-images of the speaker's anatomy and the simultaneous recording of speech. Since the computational model has separate models for the vocal folds and the vocal tract, patients undergoing an orthognathic surgery is an optimal test object for the model development. Vocal folds remain unchanged while substantial changes take place in the vocal tract. Moreover, since the aim of the research is to predict acoustic changes in speech due to operations in head neck area, the orthognathic patient group is par excellence an example of such a prediction problem. If the model can be shown to give valuable information pre-operationally, many other patient groups could benefit from the results.

Conditions

Jaw Deformity; Facial Asymmetry

Keywords

Orthognathic surgery; Speech production; MRI

Outcome Measures

Primary Outcomes (1)

• Acoustic changes in vowel production of hte patients duoe to orthognathic surgery

  a measurement of sound formants

  6 and 30 weeks postoperatively

Secondary Outcomes (1)

• Anatomical changes in vocal tract due to orthognathic surgery

  6 and 30 weeks postoperatively

Study Arms (1)

Computational modeling

EXPERIMENTAL

Other: MRI examination

Interventions

MRI examination OTHER

The vocal and nasal tracts from the lips and nostrils to the beginning of the trachea are imaged with Siemens Avanto 1.5T MRI machine using carefully optimized, externally triggered imaging sequences that are synchronized with the rest of the experimental setting. A sound sample, given by the test subject, is recorded simultaneously to obtain a coupled data set: the speech sound and the precise anatomy which produces it.

Also known as: with Siemens Avanto 1.5T MRI machine

Computational modeling

Eligibility Criteria

• Age: 18 Years - 50 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• \- Healthy patients undergoing orthognathic surgery

You may not qualify if:

• Patients with conditions in which MRI examination is contraindicated (e.g. pace maker)
• Patients who require several operations or segmented jaw surgery
• Patients with cognitive impairment
• Patients with numerous dental amalgam fillings that may cause artifacts in MR images

Sponsors & Collaborators

• Turku University Hospital: lead

Study Sites (1)

Turku University Hospital

Turku, F!-20521 Turku, Finland

RECRUITING

MeSH Terms

Conditions

Jaw Abnormalities; Facial Asymmetry

Condition Hierarchy (Ancestors)

Jaw Diseases; Musculoskeletal Diseases; Maxillofacial Abnormalities; Craniofacial Abnormalities; Musculoskeletal Abnormalities; Stomatognathic Diseases; Stomatognathic System Abnormalities; Congenital Abnormalities; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Pathological Conditions, Anatomical; Pathological Conditions, Signs and Symptoms

Study Officials

• Risto P Happonen, Professor

  Turku University Hospital, Po. Box 52, FI-20521 Turku, Finland

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER GOV
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: March 28, 2013
• First Posted: June 27, 2013
• Study Start: March 1, 2012
• Primary Completion: December 1, 2013
• Study Completion: December 1, 2014
• Last Updated: June 27, 2013

Record last verified: 2013-06

Locations

FI (1)