Oxytocin's Effect on Socioemotional Aging

NCT01823146 | Completed Results

• 2 other identifiers: 39-2013UL1TR000064
• Study Type: interventional
• Target: 106
• Locations: 1 country
• Sites: 1

Brief Summary

This study will investigate the extent to which intranasal oxytocin affects changes in social decision making and evaluations of others. Oxytocin is a hormone that naturally occurs in the body and the brain and has been shown to be relevant for many behaviors, particularly in social situations. Research on the effects of oxytocin in aging is very scarce; therefore, the purpose of this research project is to determine the effects of oxytocin on socioemotional aging.

Conditions

Aging

Keywords

oxytocin; socioemotional functioning; trust; amygdala; aging

Outcome Measures

Primary Outcomes (1)

• Extent of Trust Behavior

  Average amount of monetary units invested in the context of the Trust/Lottery Game. The theoretical range was 0 to 72 monetary units across all 24 trials. Participants invested in 12 social (human person) and 12 non-social (computer) trials.The mean average amount of monetary units invested was calculated for social and non-social trials separately.

  45 minutes after drug/placebo administration

Secondary Outcomes (2)

• Meta-Mood

  2.5 hours after drug/placebo administration

• Functional Connectivity (Resting fMRI)

  1.5 hours after oxytocin/placebo administration

Study Arms (2)

Oxytocin spray

EXPERIMENTAL

single dose of 24 IU oxytocin, self-administered intranasally (IN)

Drug: Oxytocin spray

Placebo spray

PLACEBO COMPARATOR

single dose of 24 IU placebo (same solution as oxytocin spray but without oxytocin), self-administered intranasally (IN)

Drug: Placebo spray

Interventions

Oxytocin spray DRUG

single dose of 24 IU oxytocin, self-administered intranasally (IN)

Oxytocin spray

Placebo spray DRUG

single dose of 24 IU placebo (same solution as oxytocin spray but without oxytocin), self-administered intranasally (IN)

Placebo spray

Eligibility Criteria

• Age: 18 Years - 85 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Between the ages of 18-30 years or 63-85 years
• English fluency
• Caucasian
• Right-handed

You may not qualify if:

• Pregnant or possibly pregnant
• Breastfeeding
• Claustrophobia
• Currently on vasoconstrictors, pseudoephedrine or antidiuretic medication
• Large pieces of metal in the body, particularly in the face or neck
• Piercings or metal implants that cannot be removed from the body
• Surgery on the brain or any prior serious brain damage or disease
• Dementia or severe cognitive disorders
• History of hyponatremia, Syndrome of Inappropriate Antidiuretic Hormone, psychogenic polydipsia, or motion disorder

Sponsors & Collaborators

• University of Florida: lead

Study Sites (1)

University of Florida

Gainesville, Florida, 32611-2250, United States

Location

Results Point of Contact

• Title: Dr. Natalie Ebner
• Organization: University of Florida

natalie.ebner@ufl.edu

203 691 0371

Study Officials

• Natalie C Ebner, PhD

  University of Florida, Department of Psychology

  PRINCIPAL INVESTIGATOR

Publication Agreements

• PI is Sponsor Employee: No
• Restrictive Agreement: No

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, INVESTIGATOR
• Purpose: BASIC SCIENCE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: March 25, 2013
• First Posted: April 4, 2013
• Study Start: July 1, 2013
• Primary Completion: September 1, 2014
• Study Completion: September 1, 2014
• Last Updated: August 25, 2016
• Results First Posted: September 17, 2015

Record last verified: 2015-10

Locations

US (1)