Study of the Long-term Effects of Exercise on Heath Indicators in Older People

NCT01874132 | Completed Results DMC

• 1 other identifier: CVD-2009-EX
• Study Type: interventional
• Target: 66
• Locations: 1 country
• Sites: 1

Brief Summary

Cardiovascular diseases (CVD) represent the most frequent cause of death among the elderly population. Hypertension, unfavorable lipid profile, obesity and physical inactivity are among the main risk factors for CVD. In contrast, mortality from CVD is inversely related to levels of physical activity, and is lower in individuals who exercise and have higher functional fitness levels. Thus, the Centers for Disease Control and Prevention, the American College of Sports Medicine, and the American Heart Association have recommended 20-30 min of moderate-to-vigorous aerobic training for the elderly, preferably every day or at least 3 days a week in the case of vigorous exercise.The same organizations also suggest the inclusion of resistance training in order to improve functional fitness. Therefore, the purpose of this study was to compare different exercise modalities in long-term changes of CVD risk factors and physical fitness among older adults.

Conditions

Hypertension With Complications and Secondary Hypertension; Overweight and Obesity; Lipid Metabolism Disorders; Sarcopenia; Osteoporosis; Personal Satisfaction

Keywords

Exercise; Blood pressure; Lipids; Body composition; Fitness; Bone density; Quality of life

Outcome Measures

Primary Outcomes (1)

• Cardiovascular Disease Risk Factors

  Descriptive frequency of the number of cardiovascular risk factors aggregated in each participant. The risk factors considered were: (i) hypertension; (ii) obesity; and (iii) dyslipidemia.

  one year

Secondary Outcomes (1)

• Risk of Falls

  One year

Other Outcomes (1)

• Quality of Life

  One year

Study Arms (3)

Aerobic exercise training

EXPERIMENTAL

Dose response

Behavioral: Exercise training

Aerobic and resistance exercise training

EXPERIMENTAL

Dose response

Behavioral: Exercise training

Control

NO INTERVENTION

Non-exercising control group

Interventions

Exercise training BEHAVIORAL

Both training programs were of moderate-to-vigorous intensity, three days per week for nine months.

Also known as: Aerobic training, resistance training, Combined training, multicomponent training

Aerobic and resistance exercise training; Aerobic exercise training

Eligibility Criteria

• Age: 65 Years - 79 Years
• Sex: male
• Healthy Volunteers: Yes
• Age Groups: Older Adult (65+)

You may qualify if:

• Older adults living independently;
• medical approval.

You may not qualify if:

• Non-smokers;
• Non-morbidly obese;
• No history of severe hypertension;
• No history of falls;
• No orthopaedic, neurological, pulmonary, or cardiac problems.

Sponsors & Collaborators

• University of Trás-os-Montes and Alto Douro: lead

Study Sites (1)

Maia City Council facilities

Maia, 4470-384, Portugal

Location

Related Publications (7)

• Sousa N, Mendes R, Oliveira J. Response to Drs. Safer and Safer. J Am Geriatr Soc. 2014 Mar;62(3):590-1. doi: 10.1111/jgs.12712. No abstract available.

  PMID: 24628645 BACKGROUND

• Sousa N, Mendes R, Abrantes C, Sampaio J, Oliveira J. Long-term effects of aerobic training versus combined aerobic and resistance training in modifying cardiovascular disease risk factors in healthy elderly men. Geriatr Gerontol Int. 2013 Oct;13(4):928-35. doi: 10.1111/ggi.12033. Epub 2013 Feb 26.

  PMID: 23441809 RESULT

• Sousa N, Mendes R, Abrantes C, Sampaio J, Oliveira J. A randomized 9-month study of blood pressure and body fat responses to aerobic training versus combined aerobic and resistance training in older men. Exp Gerontol. 2013 Aug;48(8):727-33. doi: 10.1016/j.exger.2013.04.008. Epub 2013 Apr 26.

  PMID: 23628502 RESULT

• Sousa N, Mendes R, Abrantes C, Sampaio J, Oliveira J. Is once-weekly resistance training enough to prevent sarcopenia? J Am Geriatr Soc. 2013 Aug;61(8):1423-4. doi: 10.1111/jgs.12387. No abstract available.

  PMID: 23937497 RESULT

• Sousa N, Mendes R, Abrantes C, Sampaio J, Oliveira J. Effectiveness of combined exercise training to improve functional fitness in older adults: A randomized controlled trial. Geriatr Gerontol Int. 2014 Oct;14(4):892-8. doi: 10.1111/ggi.12188. Epub 2014 Apr 30.

  PMID: 24779956 RESULT

• Sousa N, Mendes R, Abrantes C, Sampaio J, Oliveira J. A randomized study on lipids response to different exercise programs in overweight older men. Int J Sports Med. 2014 Dec;35(13):1106-11. doi: 10.1055/s-0034-1374639. Epub 2014 Jul 10.

  PMID: 25009971 RESULT

• Sousa N, Mendes R, Silva A, Oliveira J. Combined exercise is more effective than aerobic exercise in the improvement of fall risk factors: a randomized controlled trial in community-dwelling older men. Clin Rehabil. 2017 Apr;31(4):478-486. doi: 10.1177/0269215516655857. Epub 2016 Jul 10.

  PMID: 27353246 RESULT

MeSH Terms

Conditions

Overweight; Obesity; Lipid Metabolism Disorders; Sarcopenia; Osteoporosis; Personal Satisfaction; Motor Activity

Interventions

Exercise; Resistance Training

Condition Hierarchy (Ancestors)

Overnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Metabolic Diseases; Muscular Atrophy; Neuromuscular Manifestations; Neurologic Manifestations; Nervous System Diseases; Atrophy; Pathological Conditions, Anatomical; Bone Diseases, Metabolic; Bone Diseases; Musculoskeletal Diseases; Behavior

Intervention Hierarchy (Ancestors)

Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena; Exercise Therapy; Rehabilitation; Aftercare; Continuity of Patient Care; Patient Care; Therapeutics; Physical Therapy Modalities; Physical Conditioning, Human

Results Point of Contact

• Title: Professor Nelson Sousa
• Organization: University of Trás-os-Montes e Alto Douro

nelsons@utad.pt

259350756

Study Officials

• Nelson Sousa, PhD

  Research Center in Sport Sciences, Health Sciences and Human Development; University of Trás-os-Montes e Alto Douro

  PRINCIPAL INVESTIGATOR

• José Oliveira, PhD

  Research Center in Physical Activity, Health and Leisure; Sport Faculty, University of Porto

  STUDY DIRECTOR

• Romeu Mendes, MD

  University of Trás-os-Montes and Alto Douro

  STUDY CHAIR

Publication Agreements

• PI is Sponsor Employee: Yes
• Restrictive Agreement: No

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: June 6, 2013
• First Posted: June 10, 2013
• Study Start: May 1, 2011
• Primary Completion: September 1, 2011
• Study Completion: September 1, 2014
• Last Updated: May 8, 2017
• Results First Posted: December 12, 2016

Record last verified: 2017-03

Locations

PT (1)