Effects of Sevoflurane and Ketamine on QT in Electroconvulsive Therapy
The Effects of Sevoflurane or Ketamine on QTc Interval During Electroconvulsive Therapy
1 other identifier
interventional
24
1 country
1
Brief Summary
The aim of this study was to evaluate the effect of sevoflurane or ketamine on the QTc and Tp-e interval during in patients with major depression.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for phase_4
Started Feb 2012
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
February 1, 2012
CompletedPrimary Completion
Last participant's last visit for primary outcome
April 1, 2013
CompletedStudy Completion
Last participant's last visit for all outcomes
May 1, 2013
CompletedFirst Submitted
Initial submission to the registry
June 3, 2013
CompletedFirst Posted
Study publicly available on registry
June 6, 2013
CompletedJune 6, 2013
June 1, 2013
1.2 years
June 3, 2013
June 5, 2013
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Evaluation Of QT interval
ECG were recorded before anesthetic induction (T1), after anesthetic induction (T2) and at 0, 1, 3, 10 min after the seizure ended (T3, T4, T5 and T6, respectively)during ECT anesthesia with sevoflurane and ketamine.The QT interval was measured by one author, who was unaware of group allocation.
10 minutes
Secondary Outcomes (2)
Evaluation of Tp-e interval
10 minutes
Seizure durations
120 seconds
Study Arms (2)
Group S
ACTIVE COMPARATORIn group S, sevoflurane was initiated at %8 sevoflurane for anesthesia induction and maintained at 2% to %4 until the electrical stimulus was delivered, at which time it was turned off.
Group K
ACTIVE COMPARATORIn group K, ketamine was given to 1mg/kg ıv bolus.
Interventions
sevoflurane was initiated at %8 sevoflurane for anesthesia induction and maintained at 2% to %4 until the electrical stimulus was delivered
Eligibility Criteria
You may qualify if:
- Unpremedicated
- American Society of Anesthesiologists (ASA) I-II the patients
- Major depressions patients scheduled for ECT sessions
You may not qualify if:
- pregnant
- with permanent pacemakers,
- diabetes mellitus,
- atrial fibrillation,
- electrolyte imbalance,
- patients taking antiarrhythmics and β-blockers.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Inonu Universitylead
Study Sites (1)
Turgut Ozal Medical Center
Malatya, 44315, Turkey (Türkiye)
Related Publications (1)
Erdil F, Demirbilek S, Begec Z, Ozturk E, Ersoy MO. Effects of propofol or etomidate on QT interval during electroconvulsive therapy. J ECT. 2009 Sep;25(3):174-7. doi: 10.1097/YCT.0b013e3181903fa5.
PMID: 19225403BACKGROUND
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Feray Erdil, MD
Associated Prof Dr
Study Design
- Study Type
- interventional
- Phase
- phase 4
- Allocation
- RANDOMIZED
- Masking
- QUADRUPLE
- Who Masked
- PARTICIPANT, CARE PROVIDER, INVESTIGATOR, OUTCOMES ASSESSOR
- Purpose
- TREATMENT
- Intervention Model
- CROSSOVER
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- MD
Study Record Dates
First Submitted
June 3, 2013
First Posted
June 6, 2013
Study Start
February 1, 2012
Primary Completion
April 1, 2013
Study Completion
May 1, 2013
Last Updated
June 6, 2013
Record last verified: 2013-06