RESOLVE
Reperfusion in Acute Stroke - Creating the Clinical Decision-Making Tool (RESOLVE)
Sponsor study identifier
observational
192
0 countries
N/A
Study Start
July 2013
Date type not reportedThis date has not been verified as actual or estimated.
Primary Completion
December 31, 2016
Actual (reported)Study Completion
December 31, 2016
Actual (reported)Despite abundant evident supporting the use of acute reperfusion therapy in the setting of acute ischemic stroke (AIS), adoption of this practice in routine clinical care is poor. We hypothesize that a significant barrier is the difficulty in weighing the benefits and risks of rt-PA treatment in the care of an individual patient, a problem compounded by the time urgency of decision-making and clinical fears that weigh risks of treatment more heavily than benefits. The goal of this Quality Improvement (QI) study is to leverage an IT solution that we have developed, ePRISM, that executes multivariable risk models with patient-specific data so that a personalized estimate of an individual's outcomes (both risks and benefits) with and without rt-PA, can be generated so support safer, more effective clinical care. Through an earlier project, we will have programmed ePRISM with the best available risk-stratification models and developed a clinically useful format for presenting the data to support clinical decision-making in AIS. Through QI, we propose to identify the optimal mechanism for integrating the tool within the routine flow of patient care in preparation for more definitive studies, or dissemination strategies, to improve the treatment of patients with AIS.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
December 31, 2016
Actual (reported)Click on a node to explore related trials.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
May 14, 2013
Actual (reported)May 30, 2013
Actual (reported)July 2013
Date type not reportedThis date has not been verified as actual or estimated.
December 31, 2016
Actual (reported)December 31, 2016
Actual (reported)Successful implementation of ePRISM and the RESOLVE DA in 3 ED's and a telestroke program.
Successful implementation of ePRISM and the RESOLVE DA in 3 ED's and a telestroke program. Successful implementation is defined as: 1) the activation of ePRISM and generation the RESOLVE DA by ePRISM; 2) the staff and clinician's reported value of the new RESOLVE DA for use during the rt-PA decision making process.
2 years
Patient/family satisfaction.
2 years
Knowledge transfer.
2 years
Adults with ischemic stroke.
Adult patients
Decker C, Chhatriwalla E, Gialde E, Garavalia B, Summers D, Quinlan ME, Cheng E, Rymer M, Saver JL, Chen E, Kent DM, Spertus JA. Patient-Centered Decision Support in Acute Ischemic Stroke: Qualitative Study of Patients' and Providers' Perspectives. Circ Cardiovasc Qual Outcomes. 2015 Oct;8(6 Suppl 3):S109-16. doi: 10.1161/CIRCOUTCOMES.115.002003.
John A Spertus, MD, MPH
St. Luke's Hospital, Kansas City, Missouri
Carole Decker, MSN, PhD
St. Luke's Hospital, Kansas City, Missouri
192 participants (actual enrollment reported by the registry).
First Submitted
May 14, 2013
First Posted
May 30, 2013
Study Start
July 2013
Date type not reportedThis date has not been verified as actual or estimated.
Efficacy and Safety of Mildronate for Acute Ischemic Stroke
Contact the study team to confirm eligibility.
Primary Completion
December 31, 2016
Actual (reported)Study Completion
December 31, 2016
Actual (reported)Last Updated
October 19, 2021
Record last verified: 2021-10
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Source: ClinicalTrials.gov.
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