Serum Neuroglobin and HIF-1α in Acute Ischemic Stroke

NCT02297984 | Completed

• 1 other identifier: H1583-660145
• Study Type: observational
• Target: 40
• Locations: 1 country
• Sites: 1

Brief Summary

Neuroglobin has shown rich neuroprotective effects against cerebral ischemia and hypoxia, and therefore has the potential to impact outcomes after acute ischemic stroke. Hypoxia inducible factor (HIF)-1α is neuroprotective in several models of experimental brain injury and is increased in brain after acute cerebral infarction in humans and experimental animals.The investigators sought to examine the changes in serum neuroglobin and HIF-1α concentrations in patients with acute ischemic stroke during the initial 96-h period after stroke and assessed the relation between them and the relation of them to prognosis of such patients with acute ischemic stroke.

Conditions

Acute Ischemic Stroke

Keywords

Neuroglobin; HIF-α; Acute ischemic stroke; Prognosis

Outcome Measures

Primary Outcomes (1)

• Modified Rankin Scale scores

  0 = No symptoms; 1 = No significant disability. Able to carry out all usual activities, despite some symptoms; 2 = Slight disability. Able to look after own affairs without assistance, but unable to carry out all previous activities; 3 = Moderate disability. Requires some help, but able to walk unassisted; 4 = Moderately severe disability. Unable to attend to own bodily needs without assistance, and unable to walk unassisted; 5 = Severe disability. Requires constant nursing care and attention, bedridden, incontinent; 6 = Dead.

  3 months

Secondary Outcomes (1)

• Glasgow Outcome Scale scores

  3 months

Study Arms (1)

Acute ischemic stroke

Patients who suffered from acute ischemic stroke within 12 hours for the first time before entry into the study.

Eligibility Criteria

• Age: 42 Years - 76 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

The patient group comprised 24 male and 16 female. Their age ranged from 42 to 76 years. Locations of infarct, as evidenced by radiologic and neurologic symptoms or signs, included the territories of the middle cerebral artery (13 cases), the posterior cerebral artery (9 cases) the anterior cerebral artery (8 cases), vertebrobasilar area (7 cases), and watershed area (3 cases with cortical and subcortical low densities crossing typical vascular territories).

You may qualify if:

• Clinical diagnosis of acute ischemic stroke
• Admission within 12 hours

You may not qualify if:

• Lacunar infarction
• Cerebral hemorrhagic infarction
• Epilepsy or epileptic persons
• History of neurological diseases, myocardial infarction, renal and hepatic abnormalities and metabolic diseases
• Contraindications to antiplatelet treatments
• Serial blood samples could not be obtained

Sponsors & Collaborators

• Shanghai 6th People's Hospital: lead

Study Sites (1)

Shanghai Sixth People's Hospital

Shanghai, 200233, China

Location

MeSH Terms

Conditions

Ischemic Stroke

Condition Hierarchy (Ancestors)

Stroke; Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Vascular Diseases; Cardiovascular Diseases

Study Officials

• Lixia Xue, M.D., Ph.D.

  Shanghai 6th People's Hospital

  STUDY DIRECTOR

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: PROSPECTIVE
• Target Duration: 3 Months
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Doctor

Study Record Dates

• First Submitted: November 19, 2014
• First Posted: November 21, 2014
• Study Start: October 1, 2013
• Primary Completion: September 1, 2014
• Study Completion: October 1, 2014
• Last Updated: August 11, 2020

Record last verified: 2020-08

Locations

CN (1)