NCT01862809|Completed
Cigarette Smoking and Oral Microbiota
The Effect of Smoking on Oral Microbiota
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The Effect of Smoking on Oral Microbiota
Sponsor study identifier
Secondary identifiers
observational
50
1 country
1
Study Start
May 23, 2013
Actual (reported)Primary Completion
December 5, 2014
Actual (reported)Study Completion
June 26, 2020
Actual (reported)Background: \- Normal bacteria and other tiny organisms (the microbiota) live in the mouth and nose. They contribute to human health in many ways, including digesting food and balancing hormones. Testing samples from the mouth can show how microbiotas are related to health and disease. However, the microbiota in a person's mouth differs depending on the methods of collection and the part of the mouth that is tested. Understanding what can change the microbiota (including mouth sites, and what a person eats or smokes) will give more information on how to study oral microbiota and smoking-related cancers and other diseases. Objectives:
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
June 26, 2020
Actual (reported)Click on a node to explore related trials.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
May 23, 2013
Actual (reported)May 23, 2013
Actual (reported)May 24, 2013
Actual (reported)December 5, 2014
Actual (reported)June 26, 2020
Actual (reported)This is a pilot study to demonstrate the effects of smoking on oralmicrobiotas across differenct oral cavity sites
This was a descriptive study involving \~ 25 smokers and 25 non-smokers. We found and published in 2017 that alpha diversity was lower in smokers than in nonsmokers in the buccal mucosa, but inother sample sites, microbial diversity and compositionwere not significantly different by smoking status.
ongoing
smokers
non-smokers
Healthy adult volunteers who attended a dental clinic at University of Rochester NY
University of Rochester
Rochester, New York, 14642, United States
Human Microbiome Project Consortium. Structure, function and diversity of the healthy human microbiome. Nature. 2012 Jun 13;486(7402):207-14. doi: 10.1038/nature11234.
Stampfli MR, Anderson GP. How cigarette smoke skews immune responses to promote infection, lung disease and cancer. Nat Rev Immunol. 2009 May;9(5):377-84. doi: 10.1038/nri2530.
Segata N, Haake SK, Mannon P, Lemon KP, Waldron L, Gevers D, Huttenhower C, Izard J. Composition of the adult digestive tract bacterial microbiome based on seven mouth surfaces, tonsils, throat and stool samples. Genome Biol. 2012 Jun 14;13(6):R42. doi: 10.1186/gb-2012-13-6-r42.
Neil E Caporaso, M.D.
National Cancer Institute (NCI)
50 participants (actual enrollment reported by the registry).
First Submitted
May 23, 2013
First Posted
May 24, 2013
Study Start
May 23, 2013
Actual (reported)Primary Completion
The Symptom Experience Study in Persons With Non-Small Cell Lung Cancer
Contact the study team to confirm eligibility.
December 5, 2014
Actual (reported)Study Completion
June 26, 2020
Actual (reported)Last Updated
June 30, 2020
Record last verified: 2020-06
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Source: ClinicalTrials.gov.
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