Renal Resistive Index and Cardiac Output Changes During Resuscitation Predict the Occurrence of Acute Kidney Injury in Septic Shock Patients
CORRI
Clinical Study of Renal Resistive Index and Hemodynamic Parameters Changes Caused by Fluid Resuscitation to Predict the Occurrence of Acute Kidney Injury in Septic Shock Patients
1 other identifier
observational
40
1 country
1
Brief Summary
Record the renal resistive index and hemodynamic parameters ( record the cardiac output and stroke volume if the patient's next to kin agree to undertake a PiCCO monitoring ) before and after resuscitation for severe sepsis or septic shock patients, to determine whether the changes of resistive index or hemodynamic parameters, especially the cardiac output can be a better parameter to predict AKI
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for all trials
Started Jan 2013
Shorter than P25 for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
January 1, 2013
CompletedFirst Submitted
Initial submission to the registry
May 13, 2013
CompletedFirst Posted
Study publicly available on registry
May 24, 2013
CompletedPrimary Completion
Last participant's last visit for primary outcome
January 1, 2014
CompletedStudy Completion
Last participant's last visit for all outcomes
January 1, 2014
CompletedJanuary 15, 2014
January 1, 2014
1 year
May 13, 2013
January 14, 2014
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
7 days AKI occurrence
Follow up to determine the occurrence of AKI in 7 days after inclusion.
7 days
Secondary Outcomes (1)
eGFR
until 6 hours after enrollment
Eligibility Criteria
Critical ill patients diagnosed with septic shock who required a fluid resuscitation.
You may qualify if:
- ≥18 years, Sex unlimited
- Arriving ICU in 6 hours and diagnosed with severe sepsis or septic shock
- Physician in charge decide that an aggressive fluid resuscitation was in order
You may not qualify if:
- Pregnancy, Age \<18 years
- Ongoing recovery from AKI
- Known end-stage renal disease or chronic kidney disease(glomerular filtration rate \<30mL/min/1.73m2)
- Known other causes of shock morbidly
- conditions known to modify RRI, such as renal-artery stenosis, intra-abdominal hypertension(\>35cmH2O)
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Zhongda Hospitallead
Study Sites (1)
Affiliated Zhongda Hospital of Southeast University
Nanjing, Jiangsu, 210009, China
Related Publications (1)
Luo JC, Qiu XH, Pan C, Xie JF, Yu T, Liu L, Yang Y, Qiu HB. Increased cardiac index attenuates septic acute kidney injury: a prospective observational study. BMC Anesthesiol. 2015 Mar 1;15:22. doi: 10.1186/s12871-015-0005-0. eCollection 2015.
PMID: 25745357DERIVED
Biospecimen
For every enrolled patient,we will collect 5ml blood plasma for renal function examination, and this point will fully informed and approved by the Ethic Committee.
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- physician
Study Record Dates
First Submitted
May 13, 2013
First Posted
May 24, 2013
Study Start
January 1, 2013
Primary Completion
January 1, 2014
Study Completion
January 1, 2014
Last Updated
January 15, 2014
Record last verified: 2014-01