NCT00346541|Completed
Role of Polymorphisms in the IL-1 Gene Cluster
Investigating the Genetic Basis of Glaucoma: Role of Polymorphisms in the IL-1 Gene Cluster
Loading search results
Investigating the Genetic Basis of Glaucoma: Role of Polymorphisms in the IL-1 Gene Cluster
Sponsor study identifier
observational
400
1 country
1
Study Start
July 2005
Date type not reportedThis date has not been verified as actual or estimated.
Primary Completion
Not reported
Date not reportedStudy Completion
June 2006
Date type not reportedThis date has not been verified as actual or estimated.
Glaucoma, an optic neuropathy characterized by progressive visual field loss, is the leading cause of irreversible blindness worldwide. The condition has a substantial heritable basis, as illustrated by the numerous loci and genes identified to date, and the large proportion of patients having a family history. Interleukin-1 (Il-1) is an important mediator of inflammation. There are 2 pro-inflammatory cytokines, Il-1 alpha and Il-1 beta. The genes encoding Il-1 are located within a 430kb region on chromosome 2q14.2. The role of Il-1 in glaucoma is a subject of recent interest. It has been shown that Il-1, produced endogenously by glaucomatous cells, inhibits the apoptotic response to oxidative stress, and Il-1 has also been reported to increase outflow facility by stimulating the \_expression of matrix metalloproteinase enzymes, which in turn reduces extra cellular resistance. Recently, polymorphisms in Il-1 (particularly +3953T of the Il-1 β) were found to reduce the risk of primary open angle glaucoma. In this pilot study, we aim to investigate the role of Il-1 polymorphisms in both normal tension and high pressure glaucoma in our glaucoma patients. Both open and closed angle glaucoma will be studied. This is a pilot study of the role of immune system related polymorphisms and depending on the results, we may embark on a larger investigation of other immune genes in glaucoma
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
June 2006
Date type not reportedThis date has not been verified as actual or estimated.
Click on a node to explore related trials.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
July 2005
Date type not reportedThis date has not been verified as actual or estimated.
June 2006
Date type not reportedThis date has not been verified as actual or estimated.
June 29, 2006
Actual (reported)June 30, 2006
Actual (reported)Contact the study team to confirm eligibility.
Singapore National Eye Centre
Singapore, 168751, Singapore
Tin Aung, PHD, FRCS
Singapore Eye Research Institute
First Submitted
June 29, 2006
First Posted
June 30, 2006
Study Start
July 2005
Date type not reportedThis date has not been verified as actual or estimated.
Study Completion
June 2006
Date type not reportedAssessment of the Ability to Distinguish Odors in Glaucoma Patients
This date has not been verified as actual or estimated.
Last Updated
June 30, 2006
Record last verified: 2006-06
Download the complete ClinicalTrials.gov record imported by Syfrah, including fields not shown in this page. The registry may contain a newer revision.
Source: ClinicalTrials.gov.
JSON downloads include source attribution and retrieval details alongside the unchanged original record or the separately normalized values.
Source retrieved: